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Dog (Canine) Monoclonal TLR3 Primary Antibody for FACS, ICC - ABIN4360082
Wen, Peng, Li, Wong: The effect of innate immunity on autoimmune diabetes and the expression of Toll-like receptors on pancreatic islets. in Journal of immunology (Baltimore, Md. : 1950) 2004
Show all 65 Pubmed References
Dog (Canine) Monoclonal TLR3 Primary Antibody for FACS - ABIN4360083
Funami, Matsumoto, Oshiumi, Akazawa, Yamamoto, Seya: The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signaling. in International immunology 2004
Show all 25 Pubmed References
Dog (Canine) Monoclonal TLR3 Primary Antibody for FACS, ICC - ABIN4360084
Evangelista, Castro, Alves, Dias, Souza, Reis, Silva, Castañon, Farias, Juliano, Ferreira: Early IFN-γ production together with decreased expression of TLR3 and TLR9 characterizes EAE development conditional on the presence of myelin. in Autoimmunity 2016
Show all 24 Pubmed References
Dog (Canine) Monoclonal TLR3 Primary Antibody for ELISA - ABIN4248101
Ranjith-Kumar, Miller, Xiong, Russell, Lamb, Santos, Duffy, Cleveland, Park, Bhardwaj, Wu, Russell, Sarisky, Mbow, Kao: Biochemical and functional analyses of the human Toll-like receptor 3 ectodomain. in The Journal of biological chemistry 2007
Show all 21 Pubmed References
Human Polyclonal TLR3 Primary Antibody for FACS, IHC (fro) - ABIN252527
Patole, Gröne, Segerer, Ciubar, Belemezova, Henger, Kretzler, Schlöndorff, Anders: Viral double-stranded RNA aggravates lupus nephritis through Toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells. in Journal of the American Society of Nephrology : JASN 2005
Show all 14 Pubmed References
Human Monoclonal TLR3 Primary Antibody for FACS, IF - ABIN2191973
Matsumoto, Kikkawa, Kohase, Miyake, Seya: Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. in Biochemical and biophysical research communications 2002
Show all 6 Pubmed References
Human Monoclonal TLR3 Primary Antibody for FACS, IF - ABIN2191974
Oshiumi, Matsumoto, Funami, Akazawa, Seya: TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. in Nature immunology 2003
Show all 6 Pubmed References
Human Monoclonal TLR3 Primary Antibody for FACS, IF - ABIN2191972
Matsumoto, Funami, Tanabe, Oshiumi, Shingai, Seto, Yamamoto, Seya: Subcellular localization of Toll-like receptor 3 in human dendritic cells. in Journal of immunology (Baltimore, Md. : 1950) 2003
Show all 6 Pubmed References
Human Polyclonal TLR3 Primary Antibody for ICC, IF - ABIN4360085
Hsieh, Chang, Chen, Li, Chuang, Yu, Cheung, Chen, Maa, Leu: The inducible nitric-oxide synthase (iNOS)/Src axis mediates Toll-like receptor 3 tyrosine 759 phosphorylation and enhances its signal transduction, leading to interferon-β synthesis in macrophages. in The Journal of biological chemistry 2014
Show all 6 Pubmed References
Bird (Avian) Polyclonal TLR3 Primary Antibody for FACS, IHC (p) - ABIN4360080
Kuzemtseva, de la Torre, Martín, Soldevila, Ait-Ali, Mateu, Darwich: Regulation of toll-like receptors 3, 7 and 9 in porcine alveolar macrophages by different genotype 1 strains of porcine reproductive and respiratory syndrome virus. in Veterinary immunology and immunopathology 2014
Show all 4 Pubmed References
Positive rates of iNOS (show NOS2 Antibodies) in cervical tissues were 72.1%, 28.2%, and 3.1% in the -HPV-positive patients with cervical cancer (CC group), HR-HPV group, and controls, respectively (P < 0.05). Levels of TLR3, TLR4 (show TLR4 Antibodies), TLR7 (show TLR7 Antibodies), TLR8 (show TLR8 Antibodies), NF-kappaB (show NFKB1 Antibodies) p65 (show GORASP1 Antibodies), and iNOS (show NOS2 Antibodies) in cervical epithelial cells were higher in CC group than in other groups.
TLR signaling, in particular TLR3 activation, can efficiently reactivate HIV transcription in infected microglia, but not in monocytes or T cells
This study revealed that TLR2 rs3804100 and TLR3 rs3775291 polymorphisms may be protective factors for HBV-related hepatocellular carcinoma .
TLR3 stimulation induces the Warburg effect in head and neck squamous carcinoma cells in vitro, and suggest that TLR3 may play a role in tumor adaptation to hypoxia.
we report that autophagy is associated with apoptosis processes, involving LC3 (show MAP1LC3A Antibodies) and TRIF (show TRIM69 Antibodies)-colocation in human HCC (show FAM126A Antibodies) cells. Regulation of autophagy and the TLR3-TRIF (show TRIM69 Antibodies) pathway may be effective in the treatment of liver cancer.
Polymorphism of CD209 (show CD209 Antibodies) and TLR3 genes in populations of North Eurasia
TLR3-activated signaling enhanced the therapeutic effects of human umbilical cord-derived mesenchymal stem cells in a mouse model of colitis
the TLR3 Leu412Phe CC genotype is independently associated with severity of hepatitis C recurrence after LT.
These data demonstrate that in the absence of HBsAg, hepatic hepatitis B virus replication leads to Tlr3-dependent interferon (show IFNA Antibodies) responses in non-parenchymal liver cells.
Study found that the astrocytic TLR3-mediated cytokine expression profile is modulated by prostaglandin, and NF-kappaB (show NFKB1 Antibodies), ERK1/2 and GSK-3beta are involved in the modulatory mechanism. These results suggest that pathological conditions with increased COX (show COX8A Antibodies) activity can neuroimmunologically alter neuron-glia interaction.
TLR3 signaling contributes to Wallerian degeneration after peripheral nerve injury by affecting Schwann cell activation.
This study establishes a correlation between TLR-3 and TLR-9 (show TLR9 Antibodies) expression with the development of EAE. In addition, evidence of a role for the myelin peptide in targeting the innate inflammatory response to the CNS is presented.
Data show that HCFC2 (show HCFC2 Antibodies) is a critical component of the IRF1 (show IRF1 Antibodies) and IRF2 (show IRF2 Antibodies) transcriptional machinery that regulates Tlr3 gene expression.
the JAK (show JAK3 Antibodies)-STAT (show STAT1 Antibodies) pathway provides a cytokine rheostat mechanism, which enables macrophages to fine-tune their responses to multiple, temporally separated infection events involving the TLR3 and TLR7 (show TLR7 Antibodies) pathways.
These results suggest that testicular innate immune responses to pathogens caused by nano-TiO2 may be involved in the regulatory mechanisms of TAM (show CCNA1 Antibodies)/TLR3 signaling in testicular Sertoli cells.
findings report that RKIP (show PEBP1 Antibodies) preferentially regulates the TLR3-mediated immune response in macrophages; phosphorylation of RKIP (show PEBP1 Antibodies) serine 109 is required for RKIP (show PEBP1 Antibodies) to promote TLR3-mediated signaling and inflammation
Furthermore, Leishmania RNA virus 1-induced TLR-3 activation promoted parasite persistence by enhancing macrophage survival through Akt (show AKT1 Antibodies) activation in a manner partially dependent on miR (show MLXIP Antibodies)-155.
Primary tumor-derived exosomal RNAs, which are enriched in small nuclear RNAs, activate TLR3 in lung epithelial cells, consequently inducing chemokine (show CCL1 Antibodies) secretion in the lung and promoting neutrophil recruitment.
Autophagy contributes to macrophage resistance to Leishmania major. Data, including data from studies in knockout mice, suggest a key resistance mechanism involves endosomal signaling via Tlr3/7/9 in macrophages; macrophages deficient for Tlr3/7/9, Unc93b1 (show UNC93B1 Antibodies), or MyD88 (show MYD88 Antibodies) fail to undergo L. major-induced autophagy. (TLR = Toll (show TLR4 Antibodies)-like receptor; Unc93b1 (show UNC93B1 Antibodies) = unc-93 (show UNC93B1 Antibodies) homolog B1; MyD88 (show MYD88 Antibodies) = myeloid differentiation primary response gene 88 (show MYD88 Antibodies))
Our study reveals a novel mechanism of TLR3 in regulation of dendritic morphology and provides an explanation for how environmental factors influence mental health.
These data demonstrated that TLR2, TLR3 and TLR9 (show TLR9 Antibodies) contribute to NF-kappaB (show NFKB1 Antibodies) activation in response to porcine epidemic diarrhea virus infection, but not RIG-I (show DDX58 Antibodies).
TLR3 is regulated differentially by different genotype 1 PRRSV strains and this seems to be related apparently to the replication levels of each strain, as well as, to the TNF-alpha (show TNF Antibodies) inducing capability.
5 known non-synonymous single nucleotide polymorphisms (SNPs) were characterized in the coding sequences of the porcine TLR3 gene.
Activation of porcine TLR3 signaling is important in stimulating effective responses to PRRSV infection.
The results from this study demonstrate that expression of at least TLR3, TLR7 (show TLR7 Antibodies) and TLR8 (show TLR8 Antibodies) is stimulated upon bovine alpha-herpesvirus infection of the brain.
TLR2, 3, 4, and 8 mRNA expression is strongly upregulated and correlates with the progression of atherosclerosis in the aorta. Fluvastatin significantly inhibited this progress and reduced inflammation via TLR downregulation.
18 SNPs of TLR3 were observed and only 4 polymorphic positions were detected in the domestic breeds and 14 non-synonymous substitutions were observed, most of them in the LRR molecules.
Differential gene expression following TLR stimulation in rag1 (show RAG1 Antibodies)-/- mutant zebrafish tissues and morphological descriptions of lymphocyte-like cell populations
Binding energy (BE) calculation using MM/PBSA method from the TLR3- and TLR22-ligand complexes revealed an adequate binding affinity between TLR22-monomer and dsRNA as like as TLR3-dimer-dsRNA complex.
Full-length tlr3 was functionally characterized.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.
toll-like receptor 3
, toll-like receptor 3-like
, toll-like receptor 3 variant 1