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|Antigen||Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) Antibodies|
|Epitope||AA 207-247 Alternatives|
|Reactivity||Dog (Canine), Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This DKK1 antibody is un-conjugated Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|3 references available|
|Supplier||Log in to see|
Product Details anti-DKK1 AntibodyTarget Details DKK1 Application Details Handling References for anti-DKK1 antibody (ABIN678158) Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human DKK1|
|Plasmids, Primers & others|
Target Details DKK1Product Details anti-DKK1 Antibody Application Details Handling References for anti-DKK1 antibody (ABIN678158) Images back to top
|Alternative Name||Dkk1 (DKK1 Antibody Abstract)|
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Subcellular location: Secreted
Synonyms: SK, DKK-1, Dickkopf-related protein 1, Dickkopf-1, hDkk-1, DKK1, UNQ492/PRO18
|Pathways||WNT Signaling, Regulation of Muscle Cell Differentiation, Positive Regulation of fat Cell Differentiation|
Application DetailsProduct Details anti-DKK1 Antibody Target Details DKK1 Handling References for anti-DKK1 antibody (ABIN678158) Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-DKK1 Antibody Target Details DKK1 Application Details References for anti-DKK1 antibody (ABIN678158) Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at -20°C|
|Expiry Date||12 months|
References for anti-DKK1 antibody (ABIN678158)Product Details anti-DKK1 Antibody Target Details DKK1 Application Details Handling Images back to top
|Product cited in:||
Duan, Yan, Chen, Wu, Han, Guo, Qiao: "TET1 inhibits EMT of ovarian cancer cells through activating Wnt/β-catenin signaling inhibitors DKK1 and SFRP2." in: Gynecologic oncology, Vol. 147, Issue 2, pp. 408-417, 2017 Method employed by authors: Western Blotting (WB) (Sample species: Human).
Lu, Duan, Zhang, Wu, Wang: "Expression of Wnt3a, Wnt10b, ?-catenin and DKK1 in periodontium during orthodontic tooth movement in rats." in: Acta odontologica Scandinavica, pp. 1-7, 2015 Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Rat (Rattus)).
Król, Mucha, Majchrzak, Homa, Bulkowska, Majewska, Gajewska, Pietrzak, Perszko, Romanowska, Paw?owski, Manuali, Hellmen, Motyl: "Macrophages mediate a switch between canonical and non-canonical Wnt pathways in canine mammary tumors." in: PLoS ONE, Vol. 9, Issue 1, pp. e83995, 2014 Method employed by authors: Western Blotting (WB) (Sample species: Dog (Canine)).
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