|Antigen||Low Density Lipoprotein Receptor-Related Protein 5 (LRP5) Antibodies|
|Epitope||Internal Region Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This LRP5 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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Product Details anti-LRP5 AntibodyTarget Details LRP5 Application Details Handling Images
|Specificity||This antibody recognizes LRP5.|
Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.
|Purification||Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide|
|Immunogen||Peptide with sequence C-ERVEKTTGDKRT, from the internal region of the protein sequence Genename: LRP5|
Target Details LRP5Product Details anti-LRP5 Antibody Application Details Handling Images back to top
|Alternative Name||LRP5 (LRP5 Antibody Abstract)|
|Background||LRP5 is involved in the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. Defects in LRP5 are a cause of autosomal dominant and autosomal recessive familial exudative vitreoretinopathy (FEVR). Autosomal dominant FEVR is also referred to as exudative vitreoretinopathy 1 (EVR1), also known as Criswick-Schepens syndrome. FEVR is a disorder of the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina. This may lead to compensatory retinal neovascularization, which is thought to be induced by hypoxia from the initial avascular insult. New vessels are prone to leakage and rupture causing exudates and bleeding, followed by scarring, retinal detachment and blindness. FEVR is reported to have a penetrance of 100 % , but clinical features can be highly variable, even within the same family. Patients with mild forms of the disease are asymptomatic, and their only disease-related abnormality is an arc of avascular retina in the extreme temporal periphery.Synonyms: LRP-5, LRP7, Low-density lipoprotein receptor-related protein 5|
|Gene ID||4041, 9606|
|Pathways||WNT Signaling, Stem Cell Maintenance, Positive Regulation of fat Cell Differentiation|
Application DetailsProduct Details anti-LRP5 Antibody Target Details LRP5 Handling Images back to top
Peptide ELISA: Detection Limit: 1/128000. Immunohistochemistry: 3-6 μg/mL. In Paraffin Embedded Human Kidney shows primarily nuclear envelope staining in PCT-.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-LRP5 Antibody Target Details LRP5 Application Details Images back to top
|Buffer||Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|