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The protein encoded by FBLN5 is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. Additionally we are shipping Fibulin 5 Kits (37) and Fibulin 5 Proteins (15) and many more products for this protein.
Showing 10 out of 123 products:
Human Monoclonal Fibulin 5 Primary Antibody for IHC, ELISA - ABIN969131
Markova, Zou, Ringpfeil, Sasaki, Kostka, Timpl, Uitto, Chu: Genetic heterogeneity of cutis laxa: a heterozygous tandem duplication within the fibulin-5 (FBLN5) gene. in American journal of human genetics 2003
Show all 4 references for ABIN969131
Human Monoclonal Fibulin 5 Primary Antibody for ELISA, WB - ABIN969145
Wen, Hochholdinger, Sauer, Bruce, Schnable: The roothairless1 gene of maize encodes a homolog of sec3, which is involved in polar exocytosis. in Plant physiology 2005
Show all 4 references for ABIN969145
Human Monoclonal Fibulin 5 Primary Antibody for IHC, ELISA - ABIN969144
Kadoya, Sasaki, Kostka, Timpl, Matsuzaki, Kumagai, Sakai, Nishiyama, Amano: Fibulin-5 deposition in human skin: decrease with ageing and ultraviolet B exposure and increase in solar elastosis. in The British journal of dermatology 2005
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Human Monoclonal Fibulin 5 Primary Antibody for EIA, IHC (p) - ABIN1107240
Lee, Roy, Mogford, Schiemann, Mustoe: Fibulin-5 promotes wound healing in vivo. in Journal of the American College of Surgeons 2004
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Human Monoclonal Fibulin 5 Primary Antibody for IHC, WB - ABIN2869298
Clark, Gurney, Abaya, Baker, Baldwin, Brush, Chen, Chow, Chui, Crowley, Currell, Deuel, Dowd, Eaton, Foster, Grimaldi, Gu, Hass, Heldens, Huang, Kim, Klimowski, Jin, Johnson, Lee, Lewis, Liao, Mark et al.: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ... in Genome research 2003
Show all 2 references for ABIN2869298
Human Polyclonal Fibulin 5 Primary Antibody for ELISA, WB - ABIN185699
Albig, Neil, Schiemann: Fibulins 3 and 5 antagonize tumor angiogenesis in vivo. in Cancer research 2006
Fibulin-5 is significantly down-regulated in ovarian carcinoma and acts as a tumour suppressor by inhibiting the migration and invasion of ovarian cancer cells.
Data indicate that Fbln5 promotes PDAC progression by functioning as a molecular rheostat that modulates cell-ECM (show MMRN1 Antibodies) interactions to reduce ROS (show ROS1 Antibodies) production, and thus tip the balance in favor of tumor cell survival and treatment-refractory disease.
Data suggest that fibulin-5 functions as a metastasis suppressor in lung cancer by modulating tumor microenvironment to suppress Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling.
Fibulin-5 may be implicated in the aetiology of rectal prolapse in a subgroup of young male patients.
Fibulin-5 expression is a disease marker of hepatic fibrosis.
Loss of FBLN5 expression is associated with glioma.
Up-regulation of elastin (show ELN Antibodies) and fibulin-5 mRNA levels in ICA were strongly correlated with family history of cardiovascular disease when compared to CCA (show FBN2 Antibodies)
Data suggest that expression of FBLN5 (fibulin 5) and LOXL1 (lysyl oxidase-like protein 1 (show LOXL1 Antibodies)) (but not expression of elastin (show ELN Antibodies)) is down-regulated in uterosacral ligaments of postmenopausal women with pelvic organ prolapse.
These results indicate that Fibulin-5 inhibits hepatocellular carcinoma invasion and metastasis by suppressing matrix metalloproteinase-7 (show MMP7 Antibodies) expression.
Fibulin-5 plays critical roles in proliferation, migration and invasion of certain tumors, and the effect of fibulin-5 on tumorigenesis appears to be largely context-dependent. (Review)
While premaxillo-maxillary suture mesenchymal cells in fibulin-5-null mice were capable of differentiating into osteoblasts, suture cells in mutant mice were less proliferative.
These results are consistent with a role for TGFbeta2 in lung septation and for Ltbp4 (show LTBP4 Antibodies) in regulating fibulin-5 dependent elastic fiber assembly.
Without LTBP-4 (show LTBP4 Antibodies), fibulin-5 and tropoelastin (show ELN Antibodies) deposition was discontinuous and punctate in vitro and in vivo
This study used the maturation of fibulin-5 knockout (KO) and wild-type mice to study the effects of fragmented elastic fibers on the growth and remodeling of carotid arteries.
suggest that uPA (show PLAU Antibodies) promotes cell migration by binding to fibulin-5, initiating its cleavage by plasmin (show PLG Antibodies), which leads to its dissociation from beta1-integrin and thereby unblocks the capacity of integrin to facilitate cell motility
MMP9 (show MMP9 Antibodies) and fibulin-5 have roles in progression of pelvic organ prolapse in mice and humans
mechanical testing and confocal imaging of common carotid arteries from fibulin-5 null mice and littermate controls to characterize the mechanical behavior and microstructural content of these arteries
These findings introduce a novel function for Fbln5 in the regulation of integrin-induced reactive oxygen species production.
These results suggest a novel regulatory mechanism of elastic fiber assembly in which LTBP-2 (show LTBP2 Antibodies) regulates targeting of DANCE on suitable microfibrils to form elastic fibers.
The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3).
, fibulin 5
, developmental arteries and neural crest EGF-like protein
, urine p50 protein
, embryonic vascular EGF repeat-containing protein