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GCKR encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. Additionally we are shipping GCKR Kits (23) and GCKR Proteins (17) and many more products for this protein.
Showing 10 out of 87 products:
Mouse (Murine) Polyclonal GCKR Primary Antibody for ELISA, WB - ABIN451749
Kathiresan, Melander, Guiducci, Surti, Burtt, Rieder, Cooper, Roos, Voight, Havulinna, Wahlstrand, Hedner, Corella, Tai, Ordovas, Berglund, Vartiainen, Jousilahti, Hedblad, Taskinen, Newton-Cheh et al.: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. ... in Nature genetics 2008
Show all 2 references for ABIN451749
Human Polyclonal GCKR Primary Antibody for ELISA, WB - ABIN1533887
Hayward, Dunlop, Intody, Leek, Markham, Warner, Bonthron: Organization of the human glucokinase regulator gene GCKR. in Genomics 1998
Among Mexicans, the PNPLA3 (show PNPLA3 Antibodies) (rs738409), LYPLAL1 (show LYPLAL1 Antibodies) (rs12137855), PPP1R3B (show PPP1R3B Antibodies) (rs4240624), and GCKR (rs780094) polymorphisms may be associated with a greater risk of chronic liver disease among overweight adults.
The present study explored the association between a common variant of the glucokinase regulator (GCKR) gene and metabolic syndrome and its related traits in Taiwanese adolescents
This study shows that in patients with type 2 diabetes who were not selected for liver abnormalities, liver fat content was related to GCKR rs1260326 polymorphism
Lifestyle Intervention for Weight Loss and Cardiometabolic Changes in the Setting of Glucokinase Regulatory Protein Inhibition: Glucokinase Regulatory Protein-Leu446Pro Variant in Look AHEAD
The GCKR rs780092 variant showed opposite-directional associations with type 2 diabetes and hypertriacylglycerolaemia in a Chinese population.
Given that acetylated GKRP may affiliate with type-2 diabetes mellitus (T2DM), understanding the mechanism of GKRP acetylation in the liver could reveal novel targets within the GK-GKRP pathway, for treating T2DM and other metabolic pathologies.
The AA genotype of the GCKR rs780094 polymorphism may increase the risk of T2D among ethnic Uygurs from Xinjiang.
Two new polymorphisms associated with gall bladder disease and obesity in women have been identified, GCKR rs1260326, and TTC39B rs686030.
We found that the PPARGC1A (show PPARGC1A Antibodies) and PNPLA3 (show PNPLA3 Antibodies) variants, but not the GCKR variant, were associated with NASH (show SAMSN1 Antibodies).
Disruption of the GKRP-glucokinase (show GCK Antibodies) complex is a promising new antidiabetic target, since it results in lower plasma glucose levels without inducing hypoglycemia[review]
Glucokinase regulatory protein binds to a super-open conformation of GK mainly through hydrophobic interaction, inhibiting the GK activity by locking a small domain of GK.
Germinal center kinase-related (show MAP4K5 Antibodies) enzyme (GCKR) facilitates both canonical and noncanonical Wnt (show WNT2 Antibodies) signaling in B lymphocytes.
This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY).
glucokinase regulatory protein
, glucokinase regulator
, MAPK/ERK kinase kinase kinase 5
, MEK kinase kinase 5
, MEKKK 5