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RUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. Additionally we are shipping RUNX2 Kits (47) and RUNX2 Proteins (12) and many more products for this protein.
Showing 10 out of 236 products:
Human Polyclonal RUNX2 Primary Antibody for DB - ABIN389942
McNamara, Sjöström, Burgess, Kim, Liu, Gordonov, Moghe, Meek, Oreffo, Su, Dalby: Skeletal stem cell physiology on functionally distinct titania nanotopographies. in Biomaterials 2011
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Human Polyclonal RUNX2 Primary Antibody for WB - ABIN3043708
Li, Chen, Peng, Zhou, Fang: Pulsed electromagnetic fields protect the balance between adipogenesis and osteogenesis on steroid-induced osteonecrosis of femoral head at the pre-collapse stage in rats. in Bioelectromagnetics 2014
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Human Polyclonal RUNX2 Primary Antibody for WB - ABIN3043428
Wang, Mu, Fan, Yu, Yan, Lei, Tang, Wang, Zheng, Yu, Zhang: Insulin-like growth factor 1 can promote the osteogenic differentiation and osteogenesis of stem cells from apical papilla. in Stem cell research 2012
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Human Polyclonal RUNX2 Primary Antibody for EIA - ABIN358487
Ermakov, Malkin, Keter, Kobyliansky, Livshits: Family-based association study of polymorphisms in the RUNX2 locus with hand bone length and hand BMD. in Annals of human genetics 2008
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Cow (Bovine) Polyclonal RUNX2 Primary Antibody for WB - ABIN2780589
Rich, Rosová, Nolta, Myckatyn, Sandell, McAlinden: Upregulation of Runx2 and Osterix during in vitro chondrogenesis of human adipose-derived stromal cells. in Biochemical and biophysical research communications 2008
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Cow (Bovine) Polyclonal RUNX2 Primary Antibody for WB - ABIN2774905
Guo, Chung, Yang, Karsenty, Bringhurst, Kronenberg: PTH/PTHrP receptor delays chondrocyte hypertrophy via both Runx2-dependent and -independent pathways. in Developmental biology 2006
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Cow (Bovine) Polyclonal RUNX2 Primary Antibody for WB - ABIN2780588
Lee, Lee, Ryoo, Park, Park, Bae, Cho, Park: The odontogenic ameloblast-associated protein (ODAM) cooperates with RUNX2 and modulates enamel mineralization via regulation of MMP-20. in Journal of cellular biochemistry 2010
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Cow (Bovine) Polyclonal RUNX2 Primary Antibody for WB - ABIN2774906
Ducy, Zhang, Geoffroy, Ridall, Karsenty: Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. in Cell 1997
Runx2 may have an evolutionarily conserved role in axis formation
SIRT1 (show SIRT1 Antibodies) interacts with and promotes the transactivation potential of RUNX2.
ABL (show ABL1 Antibodies) potentiated the assembly and activation of the RUNX2-TAZ (show TAZ Antibodies) master transcription factor complex that is required for osteoblastogenesis, while antagonizing PPARgamma (show PPARG Antibodies)-mediated adipogenesis.
urther investigation indicated that p205 (show GNB2L1 Antibodies) may disturb the formation of Runx2/Ids (show IDS Antibodies) complex and free more Runx2 to induce the differentiation process. Taken together, our findings demonstrated for the first time that p205 (show GNB2L1 Antibodies) functions as an activator in osteoblast differentiation.
identified a novel genomic region in which DNA methylation (show HELLS Antibodies) status is related to Runx2 expression and detected demethylation of Runx2-DMR (show WDR20 Antibodies) during osteoblastic differentiation in mouse and dog.
overexpression of Fam3c (show FAM3C Antibodies) caused reduction of Runx2 expression at both mRNA and protein levels. Fam3c (show FAM3C Antibodies) was localized in the cytoplasm and it was not secreted outside the cell during osteoblast differentiation and therefore, may function intracellularly. Furthermore, Fam3c (show FAM3C Antibodies) and TGF-beta1 (show TGFB1 Antibodies) were found to regulate each other reciprocally
MAP kinase (show MAPK1 Antibodies)-dependent RUNX2 phosphorylation Is necessary for epigenetic modification of chromatin during osteoblast differentiation.
These results suggested that endogenous PTH enhanced BMPR2 expression by a cAMP/PKA/CREB pathway in osteoblasts, and increased RUNX2 expression through transduction of the BMP/pSMAD1/5/8 signaling pathway
suggest that RUNX2 and USAG-1 (show SOSTDC1 Antibodies) act in an antagonistic manner
results provide evidence that WWP2 (show WWP2 Antibodies) serves as a positive regulator of osteogenesis by augmenting RUNX2 transactivation in a non-proteolytic mono-ubiquitination manner.
Klotho (show KL Antibodies) gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (show GRK4 Antibodies)-RUNX2 pathway.
miR (show MLXIP Antibodies)-466-mediated attenuation of RUNX2 as a novel therapeutic approach to regulate prostate cancer growth, particularly metastasis to bone.
miR (show MLXIP Antibodies)-203 has a crucial role in suppressing heterotopic ossification by directly targeting Runx2.
mechanical load upregulates expression of Runx2 gene via potentiation of PC1 (show PCSK1 Antibodies)-JAK2 (show JAK2 Antibodies)/STAT3 (show STAT3 Antibodies) signaling axis, culminating to possibly control osteoblastic differentiation and ultimately bone formation.
the Runx2 knockdown cells displayed activation of AMP-activated protein kinase (AMPKalpha (show GRK4 Antibodies)), the sensor of cellular metabolism. Importantly, the Runx2 knockdown in bone-derived cells resulted in increased sensitivity to both Erk1/2 (show MAPK1/3 Antibodies) inhibition and AMPKalpha (show GRK4 Antibodies) activation by PD184161 and metformin, respectively, despite increased IGF-1Rbeta and AMPKalpha (show GRK4 Antibodies) levels.
RUNX2 mutation disturbs the modulatory effects of dental follicle cells and periodontal ligament cells on the differentiation of osteoclasts and osteoblasts, thereby interfering with bone remodelling. These effects may contribute in part to the pathological manifestations of retention of primary teeth and delayed eruption of permanent teeth in patients with cleidocranial dysplasia.
RUNX2/P57 (show CDKN1C Antibodies) gene expression is strongly activated, in a process that is accompanied by enrichment of activating histone marks (H3K4me3, H3ac, and H3K27ac) at the P1 promoter region, to control osteogenic lineage commitment of umbilical cord derived mesenchymal stem cells.
provide evidence to show that CBX4 (show CBX4 Antibodies) may serve as a tumor suppressor in colorectal carcinoma by recruiting HDAC3 (show HDAC3 Antibodies) to the Runx2 promoter to impede Runx2 expression
Suggest an adhesion-dependent mechanism of RUNX2 for the osteotropism and bone colonization of breast cancer cells and implicate RUNX2 and integrin alpha5 as potential molecular markers for the prediction of bone metastasis.
our results defined a novel pathway in which dysregulation of the RUNX2/INHBA (show INHBA Antibodies) axis due to miR (show MLXIP Antibodies)-376c downregulation fosters lymph node metastasis in head and neck squamous cell carcinoma
RUNX2 regulates many features of cancer cells, including cell proliferation, migration, and resistance to apoptosis.
The results suggest that gene therapy using Runx2-modi fi ed dental pulp stem cells was more effective during bone deposition and new bone formation in tibia Distraction osteogenesis.
Runx2-modified adipose-derived stem cells promote tendon graft integration in anterior cruciate ligament reconstruction.
The OPG (show TNFSF11 Antibodies) expression levels decreased while those of RANKL (show TNFSF11 Antibodies) and RUNX2 increased during orthodontic tooth movement, which suggested that they play a role in the osteogenesis process and the reconstruction of periodontal tissue.
These data also indicate that MGP (show MGP Antibodies) is under dual regulation by runx2 through the use of various isoforms and context-dependent formation of transcriptional complexes.
This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.
runt-related transcription factor 2
, transcription factor Runx2a
, transcription factor Cbfa1
, runt-related transcription factor 2-like
, AKV core binding factor
, PEA2-alpha A
, PEBP2 alpha A
, SL3-3 enhancer factor 1 alpha A subunit
, acute myeloid leukemia 3 protein
, core binding factor alpha 1
, osteoblast-specific transcription factor 2
, polyomavirus enhancer-binding protein 2 alpha A subunit
, runt domain, alpha subunit 1
, PEBP2-alpha A
, SL3/AKV core-binding factor alpha A subunit
, core-binding factor, runt domain, alpha subunit 1
, oncogene AML-3
, runt-related factor 2
, core-binding factor subunit alpha-1
, runt related transcription factor 2
, Runx2 spliced isoform
, runt-related transcription factor 2 type I
, runt-related transcription factor 2 type II
, core binding factor alpha 1 subunit