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SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Additionally we are shipping SIGLEC10 Kits (16) and SIGLEC10 Proteins (7) and many more products for this protein.
Showing 10 out of 89 products:
Human Monoclonal SIGLEC10 Primary Antibody for FACS, IF - ABIN2658387
Kitzig, Martinez-Barriocanal, López-Botet, Sayós: Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1. in Biochemical and biophysical research communications 2002
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Human Monoclonal SIGLEC10 Primary Antibody for IF, WB - ABIN2663881
Chen, Tang, Zheng, Liu: CD24 and Siglec-10 selectively repress tissue damage-induced immune responses. in Science (New York, N.Y.) 2009
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Human Monoclonal SIGLEC10 Primary Antibody for FACS - ABIN2476477
Spiegelman, Israel, Bouchard, Willett: Absolute fat mass, percent body fat, and body-fat distribution: which is the real determinant of blood pressure and serum glucose? in The American journal of clinical nutrition 1992
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Human Monoclonal SIGLEC10 Primary Antibody for FACS - ABIN2476476
Munday, Kerr, Ni, Cornish, Zhang, Nicoll, Floyd, Mattei, Moore, Liu, Crocker: Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor. in The Biochemical journal 2001
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Human Monoclonal SIGLEC10 Primary Antibody for FACS - ABIN2476478
Nguyen, Hurtado-Ziola, Gagneux, Varki: Loss of Siglec expression on T lymphocytes during human evolution. in Proceedings of the National Academy of Sciences of the United States of America 2006
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Human Polyclonal SIGLEC10 Primary Antibody for FACS - ABIN4895910
Madge, Maggioni, Pascolutti, Amin, Waespy, Bellette, Thomson, Kelm, von Itzstein, Haselhorst: Structural characterisation of high affinity Siglec-2 (CD22) ligands in complex with whole Burkitt's lymphoma (BL) Daudi cells by NMR spectroscopy. in Scientific reports 2016
Dog (Canine) Polyclonal SIGLEC10 Primary Antibody for WB - ABIN2784077
Szafranski, Schindler, Taudien, Hiller, Huse, Jahn, Schreiber, Backofen, Platzer: Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. in Genome biology 2008
Siglec-10 is associated with decreased survival and impaired NK cell function in human hepatocellular carcinoma (HCC (show FAM126A Antibodies)).
Siglec-10-VAP-1 (show AOC3 Antibodies) interaction seems to mediate lymphocyte adhesion to endothelium
this study shows that Siglec-G inhibits dendritic cells cross-presentation by impairing such complex formation, and our results add insight into the regulation of cross-presentation in adaptive immunity
The effect for Siglec-G deficiency in B cells results in higher B-1 cell numbers and a robust and preferential increase in oxidation-specific epitopes-specific IgM antibodies, which neutralize oxidized LDL-induced inflammation in vivo.
Aging Siglec-G-deficient and Siglec-G 3/FcgammaRIIb double-deficient mice develop an autoimmune phenotype with elevated autoantibody levels and mild glomerulonephritis.
Deficiency of SIGLEC-G was found to increase susceptibility to develop B-cell lymphoproliferative disorders.
Siglec-G is recruited to the immunological synapse by sialic acid ligands on the Ag-bearing cells, producing a tolerogenic signal involving Lyn (show LYN Antibodies) and the proapoptotic factor BIM (show BCL2L11 Antibodies) that promotes deletion of the B cell and failure of mice to develop Abs to the Ag upon subsequent challenge.
Siglec-G-CD24 (show CD24 Antibodies) axis, controls the severity of GVHD and suggest that enhancing this interaction may represent a novel strategy for mitigating GVHD.
Siglec-G sialic acid-dependent binding to the BCR (show BCR Antibodies) is crucial for the B1 cell-restricted inhibitory function of Siglec-G and is regulated in an opposite way to that of the related protein CD22 (Siglec-2 (show CD22 Antibodies)) on B cells.
Data indicate that the loss of the inhibitory receptor Siglec-G led to a moderate exacerbation of disease severity and early onset in both collagen-induced arthritis and spontaneous lupus nephritis in MRL/lpr (show FAS Antibodies) mice.
Siglec-G inhibits B cell activation (show BLNK Antibodies) equally in both B1 & B2 subsets. It is expressed at a relatively constant level in numerous B cell subsets. It may maintain B cell tolerance toward self Ags (show GLA Antibodies) in various B cell compartments.
Data reveal a negative feedback loop of RIG-I (show DDX58 Antibodies) signaling and identify a Siglec-G-mediated immune evasion pathway exploited by RNA viruses.
SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).
sialic acid binding Ig-like lectin 10
, sialic acid-binding Ig-like lectin 10-like
, sialic acid binding Ig-like lectin G
, sialic acid-binding Ig-like lectin 10
, sialic acid binding Ig-like lectin 10 Ig-like lectin 7
, siglec-like gene 2
, siglec-like protein 2