anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) Antibodies

The protein encoded by TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. Additionally we are shipping TRPM2 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TRPM2 7226 O94759
TRPM2 28240  
TRPM2 294329  
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Top anti-TRPM2 Antibodies at antibodies-online.com

Showing 10 out of 95 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Rabbit Un-conjugated ICC, IHC (fro), IF, IHC, WB Staining of rat hippocampus using ABIN259658. TRPM2 is stained red, GFAP is stained green and nuclei staining is blue. Photo courtesy of Dr. Ji-Zhong Bai, The University of Auckland, New Zealand. 0.1 mL Log in to see 7 to 9 Days
$408.19
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-TRPM2 antibody, IHC(P) IHC(P): Rat Brain Tissue Anti-TRPM2 antibody, Western blotting Lane 1: Rat Brain Tissue Lysate Lane 2: Mouse Brain Tissue Lysate Lane 3: Mouse Liver Tissue Lysate Lane 4: JURKAT Cell Lysate Lane 5: HELA Cell Lysate Lane 6: A549 Cell Lysate 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IF, IP, IHC, WB Western Blot: TRPM2 Antibody  - Samples: Membrane Prep (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from Jurkat cells. Antibodies: Affinity purified rabbit anti-TRPM2 antibody (lot was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds. Western Blot: TRPM2 Antibody  - Samples: Jurkat Membrane Prep (50, 15, 5 ug). Antibody: Affinity purified rabbit anti-TRPM2 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Log in to see 7 to 9 Days
$486.94
Details
Human Rabbit Un-conjugated ICC, IF, IP, WB Western Blot: TRPM2 Antibody [ABIN153041] - Membrane Prep (50 ug) from Jurkat cells. Antibody: Affinity purified rabbit anti-TRPM2 antibody used for WB at 2 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Log in to see 7 to 9 Days
$486.94
Details
Human Goat Un-conjugated IHC (p) Brain, cortex, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Pancreas, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7 to 9 Days
$451.00
Details
Guinea Pig Rabbit Un-conjugated IHC (p), WB Brain, cortex, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Heart, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7 to 9 Days
$676.50
Details
Mouse Rabbit Un-conjugated ICC, IF, WB Detection of TRPM2 in mouse brain membrane lysates using ABIN259771. Immunocytochemistry/Immunofluorescence: TRPM2 Antibody [ABIN2597714] - TRPM2 antibody was tested in Neuro2A cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). 0.1 mL Log in to see 7 to 9 Days
$381.94
Details
Human Rabbit Un-conjugated IHC (p), IHC, WB Western Blot: TRPM2 Antibody [NBP1-33416] - Sample (30 ug of whole cell lysate) A: Hep G2 7. 5% SDS PAGE, antibody diluted at 1:500. Immunohistochemistry-Paraffin: TRPM2 Antibody [NBP1-33416] - Paraffin-embedded MDAMB468 xenograft, using antibody at 1:100 dilution. 100 μL Log in to see 7 to 9 Days
$447.56
Details
Mouse Rabbit DyLight 550 ICC, IF, IHC, IHC (fro), WB   0.1 mL Log in to see 7 to 9 Days
$500.06
Details

TRPM2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-TRPM2 Antibodies

  1. Mouse (Murine) Polyclonal TRPM2 Primary Antibody for ICC, IHC (fro) - ABIN259658 : Bai, Lipski: Differential expression of TRPM2 and TRPV4 channels and their potential role in oxidative stress-induced cell death in organotypic hippocampal culture. in Neurotoxicology 2010 (PubMed)
    Show all 8 Pubmed References

  2. Human Polyclonal TRPM2 Primary Antibody for ICC, IHC (fro) - ABIN153042 : Partida-Sanchez, Gasser, Fliegert, Siebrands, Dammermann, Shi, Mousseau, Sumoza-Toledo, Bhagat, Walseth, Guse, Lund: Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by adp-ribose, the major product generated by the CD38 enzyme reaction. in Journal of immunology (Baltimore, Md. : 1950) 2007 (PubMed)
    Show all 4 Pubmed References

  3. Polyclonal TRPM2 Primary Antibody for WB - ABIN540252 : Zhang, Chu, Tong, Cheung, Conrad, Masker, Miller: A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death. in The Journal of biological chemistry 2003 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal TRPM2 Primary Antibody for ICC, IF - ABIN153041 : Moreau, Kirchberger, Swarbrick, Bartlett, Fliegert, Yorgan, Bauche, Harneit, Guse, Potter: Structure-activity relationship of adenosine 5'-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists. in Journal of medicinal chemistry 2013 (PubMed)
    Show all 2 Pubmed References

  5. Mouse (Murine) Polyclonal TRPM2 Primary Antibody for ICC, IF - ABIN4362934 : Rah, Kwak, Chung, Kim: ADP-ribose/TRPM2-mediated Ca2+ signaling is essential for cytolytic degranulation and antitumor activity of natural killer cells. in Scientific reports 2015 (PubMed)

More Antibodies against TRPM2 Interaction Partners

Pig (Porcine) Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

  1. Study determined the sequence of pig TRPC1 and TRPC3-7 channels and found pig TRPC cDNAs resemble their human homologs more than the others .

  2. heteromeric cation channels comprised of the TRPP2 mutant and the TRPC3 (show TRPC3 Antibodies) or TRPC7 protein induce enhanced receptor-activated Ca(2 (show CA2 Antibodies)+) influx that may lead to dysregulated cell growth in ADPKD

Human Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

  1. oxidative stress activated the TRPM2 (show CLU Antibodies)-CaMKII (show CAMK2G Antibodies) cascade to further induce intracellular ROS (show ROS1 Antibodies) production, which led to mitochondria fragmentation and loss of mitochondrial membrane potential

  2. The work summarized here shows that TRPM2 (show CLU Antibodies) channels protect cardiac myocytes from ischaemia-reperfusion injury and tumour cells from doxorubicin toxicity, and demonstrates that the mechanisms involve preservation of mitochondrial bioenergetics and modulation of ROS (show ROS1 Antibodies)

  3. Activation of TRPM2 (show CLU Antibodies) channels, however, caused intracellular release of not only Ca(2 (show CA2 Antibodies)+) but also of Zn(2+) Intriguingly, elevation of intracellular Zn(2+) faithfully reproduced all of the effects of H2O2, whereas Ca(2 (show CA2 Antibodies)+) showed opposite effects. Interestingly, H2O2 caused increased trafficking of Zn(2+)-enriched lysosomes to the leading edge of migrating cells, presumably to impart polarisation of Zn(2+) location.

  4. neutrophils sense reactive oxygen species via the TRPM2 (show CLU Antibodies) channel to arrest migration at their target site.

  5. The inhibitory function of oxidant sensing by TRPM2 (show CLU Antibodies) requires the oxidation of Cys549, which then induces TRMP2 binding to formyl peptide receptor 1 (FPR1 (show FPR1 Antibodies)) and subsequent FPR1 (show FPR1 Antibodies) internalization and signaling inhibition

  6. findings demonstrate the important function of TRPM2 (show CLU Antibodies) in modulation of cell survival through mitochondrial ROS (show ROS1 Antibodies), and the potential of targeted inhibition of TRPM2 (show CLU Antibodies) as a therapeutic approach to reduce cellular bioenergetics, tumor growth, and enhance susceptibility to chemotherapeutic agents.

  7. Study demonstrate that PRL (show PRL Antibodies) is necessary for the survival of (retinal pigment epithelium) RPE (show RPE Antibodies) under normal and advancing age conditions and, identified SIRT2 (show SIRT2 Antibodies) and TRPM2 (show CLU Antibodies) as molecular targets for the antioxidant and antiapoptotic actions of PRL (show PRL Antibodies) in the RPE (show RPE Antibodies).

  8. TRPM2 (show CLU Antibodies) has a role in the DNA damage response of T cell leukemia cells in a BCL-2 (show BCL2 Antibodies) dependent manner

  9. Data show that HEK293 cells expressing low levels of receptor potential melastatin 2 (TRPM2) chan (show TRPM3 Antibodies)nel wer (show CLU Antibodies)e more susceptible to silica nanoparticles (NPs) than those expressing high levels of TRPM2.

  10. This is expected to provide a basis for inhibiting TRPM2 (show CLU Antibodies) for the improved treatment of breast cancer, which potentially includes treating breast tumors that are resistant to chemotherapy due to their evasion of apoptosis.

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

  1. Overexpression of TRPM2 channel prevented neutrophil transendothelial migration and vascular injury.

  2. These findings of this study suggest that TRPM2 channels play an essential role in mediating hypoxic-ischemic brain injury in neonatal mice.

  3. TRPM2 regulates phagosomal acidification, and is essential for the bacterial killing function of macrophages.

  4. Lysophosphatidylcholine induces intracellular Ca(2 (show CA2 Antibodies)+) influx and increases phosphorylation of p38 MAPK (show MAPK14 Antibodies) via TRPM2, which in turn activates microglia.

  5. The current study demonstrated that a physiological concentration of adrenaline attenuates insulin (show INS Antibodies) release via coupling of alpha2A-adrenoceptor to cAMP/TRPM2 signaling.

  6. Trpm2 does not seem to play a major role in myeloid leukemogenesis. Additionally, loss of Trpm2 does not augment the cytotoxicity of standard AML (show RUNX1 Antibodies) chemotherapeutic agents.

  7. TRPM2 channels contribute to visceral nociception in response to noxious stimuli under normal conditions and visceral hypersensitivity in pathological conditions.

  8. Data show that macrophages from young mice showed lower transient receptor potential melastatin 2 (show TRPM3 Antibodies) (TRPM2) expression than those from senescent mice and had lower viability after silica nanoparticles (NPs (show NPS Antibodies)) exposure than those from senescent ones.

  9. TRPM2 activation is likely to be mediated by ADP-ribose production via PARP (show PARP1 Antibodies) pathway

  10. mice in which TRPM2 had been genetically deleted showed a striking deficit in their sensation of non-noxious warm temperatures, consistent with the idea that TRPM2 initiates a 'warm' signal which drives cool-seeking behaviour

TRPM2 Antigen Profile

Protein Summary

The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Gene names and symbols associated with TRPM2

  • transient receptor potential cation channel, subfamily M, member 2 (TRPM2) antibody
  • transient receptor potential cation channel, subfamily M, member 2 (trpm2) antibody
  • transient receptor potential cation channel, subfamily M, member 2 (Trpm2) antibody
  • 9830168K16Rik antibody
  • C79133 antibody
  • EREG1 antibody
  • KNP3 antibody
  • LTRPC2 antibody
  • NUDT9H antibody
  • NUDT9L1 antibody
  • si:ch73-263b18.1 antibody
  • Trp7 antibody
  • TRPC7 antibody
  • TRPM2 antibody
  • Trpm2-predicted antibody
  • Trrp7 antibody

Protein level used designations for TRPM2

transient receptor potential cation channel, subfamily M, member 2 , transient receptor potential cation channel, subfamily C, member 7 , transient receptor potential cation channel, subfamily C, member 7-like , short transient receptor potential channel 7-like , transient receptor potential cation channel subfamily M member 2-like , transient receptor potential channel subfamily C member 7 , LTrpC-2 , estrogen-responsive element-associated gene 1 protein , long transient receptor potential channel 2 , transient receptor potential cation channel subfamily M member 2 , transient receptor potential channel 7 , transient receptor protein 7 , transient receptor potential melastatin family 2

GENE ID SPECIES
424835 Gallus gallus
470101 Pan troglodytes
703611 Macaca mulatta
799412 Danio rerio
100056810 Equus caballus
100083361 Ornithorhynchus anatinus
100124999 Xenopus (Silurana) tropicalis
100341596 Oryctolagus cuniculus
100443123 Pongo abelii
100479298 Ailuropoda melanoleuca
100479364 Ailuropoda melanoleuca
100539776 Meleagris gallopavo
100556895 Anolis carolinensis
100271727 Sus scrofa
7226 Homo sapiens
28240 Mus musculus
294329 Rattus norvegicus
508029 Bos taurus
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