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anti-phosphoglycerate Dehydrogenase (PHGDH) Antibodies

PHGDH encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. Additionally we are shipping PHGDH Kits (17) and PHGDH Proteins (12) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PHGDH 236539 Q61753
PHGDH 26227 O43175
PHGDH 58835 O08651
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Top anti-PHGDH Antibodies at antibodies-online.com

Showing 10 out of 115 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-PHGDH Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: 293T cell lysate WB Suggested Anti-PHGDH  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control:.93T cell lysate  PHGDH is supported by BioGPS gene expression data to be expressed in HEK293T 100 μL Log in to see 2 to 3 Days
$289.00
Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-PHGDH Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:12500Positive Control: 293T cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB (LEFT) Western blot analysis of PHGDH Antibody (N-term) in mouse brain tissue lysates (35ug/lane). PHGDH (arrow) was detected using the purified Pab. (RIGHT) Western blot analysis of PHGDH (arrow) using rabbit polyclonal PHGDH Antibody (N-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PHGDH gene (Lane 2) . 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of PHGDH Antibody (N-term) (ABIN389483) in mouse brain tissue lysates (35 µg/lane). PHGDH (arrow) was detected using the purified polyclonal antibody. Western blot analysis of PHGDH (arrow) using rabbit polyclonal PHGDH Antibody (N-term) (ABIN389483). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the PHGDH gene (Lane 2) . 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB PHGDH Antibody (Center) (ABIN650767) western blot analysis in Ramos cell line lysates (15 µg/lane).This demonstrates the PHGDH antibody detected the PHGDH protein (arrow). PHGDH Antibody (Center) (ABIN650767) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ICC, IF, IP, IHC (p), WB WB Image Sample (50 ug of whole cell lysate) A: Mouse brain 7.5% SDS PAGE antibody diluted at 1:1000 IHC-P Image PHGDH antibody [N1N2], N-term detects PHGDH protein at cytoplasm on mouse pancreas by immunohistochemical analysis. Sample: Paraffin-embedded mouse pancreas. PHGDH antibody [N1N2], N-term , diluted at 1:500. 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded human breast cancer, using PHGDH, antibody at 1:250 dilution. WB Image Sample (30 ug of whole cell lysate) A: A431 B: Raji 7.5% SDS PAGE antibody diluted at 1:10000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Mouse Un-conjugated IF, IHC (p), IP, ELISA, WB PHGDH monoclonal antibody (M01), clone 4A3-1D6. Western Blot analysis of PHGDH expression in human liver. PHGDH monoclonal antibody (M01), clone 4A3-1D6 Western Blot analysis of PHGDH expression in Jurkat . 100 μg Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated EIA, IF, IHC (p), IP, WB 50 μg Log in to see 6 to 8 Days
$566.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details

PHGDH Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,


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Top referenced anti-PHGDH Antibodies

  1. Dog (Canine) Polyclonal PHGDH Primary Antibody for WB - ABIN2785893 : Tsang, Connell, Brown, Thompson, Reid, Sanderson: A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. in Genomics 2006 (PubMed)

  2. Human Monoclonal PHGDH Primary Antibody for IF, IHC (p) - ABIN565240 : Pollari, Käkönen, Edgren, Wolf, Kohonen, Sara, Guise, Nees, Kallioniemi: Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis. in Breast cancer research and treatment 2010 (PubMed)

  3. Human Polyclonal PHGDH Primary Antibody for EIA, WB - ABIN453266 : Klomp, de Koning, Malingré, van Beurden, Brink, Opdam, Duran, Jaeken, Pineda, Van Maldergem, Poll-The, van den Berg, Berger: Molecular characterization of 3-phosphoglycerate dehydrogenase deficiency--a neurometabolic disorder associated with reduced L-serine biosynthesis. in American journal of human genetics 2000 (PubMed)

More Antibodies against PHGDH Interaction Partners

Arabidopsis thaliana phosphoglycerate Dehydrogenase (PHGDH) interaction partners

  1. PGDH1 (show HPGD Antibodies) is essential for Arabidopsis development.

  2. Genetic and molecular evidence were provided for the essential role of EDA9 for embryo and pollen development.

  3. Data indicate that 3-phosphoglycerate dehydrogenases PGDH (show HPGD Antibodies) (At1g17745) and EDA9 (At4g34200) were expressed preferentially in roots while 3-PGDH (At3g19480) was expressed mainly in the aerial parts and was not expressed or very poorly in roots.

Mouse (Murine) phosphoglycerate Dehydrogenase (PHGDH) interaction partners

  1. These results indicate that the PHGDH gene expression, dictated by IL-2R signaling, is a crucial event for DNA synthesis during S phase of activated T cells.

  2. Using transgenic mice expressing enhanced GFP under the Srr (show SRR Antibodies) promoter and mice with targeted deletion of Srr (show SRR Antibodies) or 3-Phosphoglycerate dehydrogenase, we demonstrate predominantly neuronal sources of d-serine dependent on astrocytic supply of l-serine.

  3. Elevated levels of 4E-BP1 (show EIF4EBP1 Antibodies) may be involved in a mechanism to arrest brain development in Phgdh knock out embryos.

  4. Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of brain D-serine, an N-methyl-D-aspartate receptor (show GRIN1 Antibodies) co-agonist

  5. Data suggest expression of Phgdh in endometrium is regulated by Hoxa10.

  6. the Phgdh-dependent phosphorylated pathway is essential for normal embryonic development, especially for brain morphogenesis

  7. the presence of cis (show CISH Antibodies)-acting elements confer the cell type specificity of Phgdh transcription in the distal promoter region.

  8. The mouse Phgdh gene spans approximately 27 kilobases in length and comprises 12 exons with 11 intervening introns and is mapped to chromosome 3, region F2-F3 by FISH.

  9. either Phgdh or ASCT1 (show SLC1A4 Antibodies) is provided to each segment of renal tubules, suggesting that metabolic interplay mediated by L-serine biosynthesis and supply may exist in the kidney

  10. Inactivation of Phgdh gene with changes in gene expression and associated regulatory networks resulting from serine deficiency are reported.

Human phosphoglycerate Dehydrogenase (PHGDH) interaction partners

  1. Overexpression of Phgdh may be generally associated with CK5 (show KRT5 Antibodies) cells, and oncogenic function may be determined by isoform expression.

  2. High expression of PHGDH is associated with Colon Cancer.

  3. p53 (show TP53 Antibodies)-mediated repression of PHGDH enhances the apoptotic response upon serine starvation in melanoma cells.

  4. Phosphoglycerate Dehydrogenase deficiency is associated with Neu-Laxova syndrome.

  5. We report on the identification of homozygous mutations in PHGDH and serine deficiency in individuals with Neu (show ERBB2 Antibodies)-Laxova syndrome. This disorder thus seems to be an extremely severe expression of PHGDH deficiency.

  6. PHGDH overexpression is found in cervical cancer, in particular, in bigger tumors and with advanced stages. Its expression is positively correlated with squamous cell carcinoma antigen level

  7. The potential mechanisms by which PHGDH promotes cancer are discussed.

  8. in some cancer cells a relatively large amount of glycolytic carbon is diverted into serine and glycine metabolism through phosphoglycerate dehydrogenase.

  9. results reveal that certain breast cancers are dependent upon increased serine pathway flux caused by PHGDH overexpression and demonstrate the utility of in vivo negative-selection RNAi screens for finding potential anticancer targets

  10. The crystal structure of Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase has been solved with bound effector, 1-serine, and substrate, hydroxypyruvic acid phosphate. The human enzyme was also examined.

PHGDH Antigen Profile

Protein Summary

This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known.

Gene names and symbols associated with PHGDH

  • phosphoglycerate dehydrogenase (phgdh) antibody
  • D-3-phosphoglycerate dehydrogenase (EDA9) antibody
  • D-3-phosphoglycerate dehydrogenase (serA) antibody
  • D-3-phosphoglycerate dehydrogenase (Sthe_2284) antibody
  • D-3-phosphoglycerate dehydrogenase (Dacet_1260) antibody
  • D-3-phosphoglycerate dehydrogenase (Mrub_0173) antibody
  • D-3-phosphoglycerate dehydrogenase (Mmah_1539) antibody
  • D-3-phosphoglycerate dehydrogenase (Arnit_0487) antibody
  • D-3-phosphoglycerate dehydrogenase (Ndas_0174) antibody
  • D-3-phosphoglycerate dehydrogenase (Mesil_2386) antibody
  • D-3-phosphoglycerate dehydrogenase (Slip_0010) antibody
  • D-3-phosphoglycerate dehydrogenase (Trad_0302) antibody
  • D-3-phosphoglycerate dehydrogenase (Acear_0027) antibody
  • D-3-phosphoglycerate dehydrogenase (Mahau_0665) antibody
  • D-3-phosphoglycerate dehydrogenase (Mzhil_1019) antibody
  • D-3-phosphoglycerate dehydrogenase (Mesop_1331) antibody
  • D-3-phosphoglycerate dehydrogenase (Thein_0855) antibody
  • 3-phosphoglycerate dehydrogenase (Phgdh) antibody
  • phosphoglycerate dehydrogenase (PHGDH) antibody
  • phosphoglycerate dehydrogenase (Phgdh) antibody
  • 3-PGDH antibody
  • 3PGDH antibody
  • 4930479N23 antibody
  • A10 antibody
  • ECK2909 antibody
  • embryo sac development arrest 9 antibody
  • F10M10.7 antibody
  • fb38f06 antibody
  • JW2880 antibody
  • PDG antibody
  • PGAD antibody
  • PGD antibody
  • PGDH antibody
  • SERA antibody
  • wu:fb38f06 antibody
  • zgc:65956 antibody

Protein level used designations for PHGDH

D-3-phosphoglycerate dehydrogenase , 3-phosphoglycerate dehyrogenase , 3-phosphoglycerate dehydrogenase , 3-PGDH

GENE ID SPECIES
321928 Danio rerio
829568 Arabidopsis thaliana
945258 Escherichia coli str. K-12 substr. MG1655
8639711 Sphaerobacter thermophilus DSM 20745
8875608 Denitrovibrio acetiphilus DSM 12809
8878240 Meiothermus ruber DSM 1279
8983712 Methanohalophilus mahii DSM 5219
9170634 Arcobacter nitrofigilis DSM 7299
9244005 Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111
9251902 Meiothermus silvanus DSM 9946
9272777 Syntrophothermus lipocalidus DSM 12680
9279275 Truepera radiovictrix DSM 17093
9512008 Acetohalobium arabaticum DSM 5501
10607400 Mahella australiensis 50-1 BON
10822643 Methanosalsum zhilinae DSM 4017
10825145 Mesorhizobium opportunistum WSM2075
10841100 Thermodesulfatator indicus DSM 15286
236539 Mus musculus
26227 Homo sapiens
58835 Rattus norvegicus
100144529 Sus scrofa
505103 Bos taurus
739534 Pan troglodytes
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