anti-C-MYC antibody (V-Myc Myelocytomatosis Viral Oncogene Homolog (Avian)) (N-Term)

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Antigen
Synonyms LOC100136746, RNCMYC, c-myc, mMyc, AU016757, Myc2, Niard, Nird, bHLHe39, MYC, cmyc, zc-myc, MRTL, MYCC, c-Myc, C-MYC, CMYC, CMyc
Alternatives
Epitope
N-Term
(100), (72), (65), (43), (41), (40), (29), (26), (22), (20), (17), (15), (13), (13), (6), (5), (5), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(701), (233), (188), (35), (13), (9), (7), (6), (5), (5), (5), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(495), (221), (29), (14), (10), (1)
Clonality
Polyclonal
Conjugate
This C-MYC antibody is un-conjugated
(45), (39), (36), (15), (14), (12), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (1), (1), (1)
Application
Western Blotting (WB)
(528), (279), (233), (138), (129), (111), (66), (59), (45), (37), (36), (14), (14), (11), (7), (6), (6), (5), (4), (2), (2), (1)
Pubmed 2 references available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the N terminal of human MYC
Blocking Peptide Blocking peptide for this product available: V-Myc Myelocytomatosis Viral Oncogene Homolog (Avian) (MYC) (N-Term) peptide (ABIN980416)
Sequence QPYFYCDEEE NFYQQQQQSE LQPPAPSEDI WKKFELLPTP PLSPSRRSGL
Predicted Reactivity African clawed frog : 100 %, Bovine : 100 %, Chicken : 100 %, Dog : 100 %, Guinea pig : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %, Sheep : 100 %, Zebrafish : 100 %
Characteristics This is a rabbit polyclonal antibody against MYC. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name MYC (MYC Antibody Abstract)
Background MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this MYC gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma.The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
Molecular Weight 50 kDa
Gene ID 4609
NCBI Accession NM_002467, NP_002458
Pathways p53 Signaling, Cell Division Cycle
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 454 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-C-MYC antibody (V-Myc Myelocytomatosis Viral Oncogene Homolog (Avian)) (N-Term) (ABIN486791) WB Suggested Anti-MYC Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1...
Product cited in: Mallampalli, Kaercher, Snavely et al.: "Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I." in: Cellular signalling, Vol. 25, Issue 10, pp. 2047-59, 2013 (PubMed).

Background publications Zhu, Blenis, Yuan: "Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 18, pp. 6584-9, 2008 (PubMed).

Catalog No. ABIN486791
$289.00
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