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c-MYC antibody (C-Term)
MYC
Reactivity: Human
WB
Host: Mouse
Monoclonal
unconjugated
Product Details anti-c-MYC Antibody
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Target
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c-MYC (MYC)
(Myc Proto-Oncogene protein (MYC))
Binding Specificity
All epitopes for c-MYC antibodies
AA 410-432, C-Term
Reactivity
All reactivities for c-MYC antibodies
Human
Host
All hosts for c-MYC antibodies
Mouse
Clonality
All clonalities for c-MYC antibodies
Monoclonal
Conjugate
All conjugates for c-MYC antibodies
This c-MYC antibody is un-conjugated
Application
All applications for c-MYC antibodies
Western Blotting (WB)
Specificity
This mouse mAb only detects transfected proteins.
Purification
Affinity purified
Immunogen
Peptide sequence derived from C-terminal (AA 410-432) of human c-Myc conjugated with KLH.
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Discover our top product MYC Primary Antibody
Alternatives
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Application Details
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Application Notes
Western blotting: 1:500-1:1000
Restrictions
For Research Use only
Handling
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Format
Liquid
Handling Advice
Avoid freezing and thawing repeatly.
Storage
4 °C/-20 °C
Storage Comment
Store at 4 °C for short term use. Store at -20 °C for long term preservation. Avoid freezing and thawing repeatly.
References for anti-c-MYC antibody (ABIN871631)
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Yang, Xia, Hawke, Li, Liang, Xing, Aldape, Hunter, Alfred Yung, Lu : "PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. " in: Cell , Vol. 150 , Issue 4 , pp. 685-96 , (2012 ) (PubMed ).
Yang, Zheng, Xia, Ji, Chen, Guo, Lyssiotis, Aldape, Cantley, Lu : "ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. " in: Nature cell biology , Vol. 14 , Issue 12 , pp. 1295-304 , (2012 ) (PubMed ).
Target Details for c-MYC
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Target
c-MYC (MYC)
(Myc Proto-Oncogene protein (MYC))
Alternative Name
Myc Proto-Oncogene protein (MYC Products )
Synonyms
MRTL antibody, MYCC antibody, bHLHe39 antibody, c-Myc antibody, CMYC antibody, c-myc antibody, C-MYC antibody, LOC100136746 antibody, ARC antibody, B430311C09Rik antibody, MYC antibody, NOP antibody, Nop30 antibody, RNCMYC antibody, mMyc antibody, AU016757 antibody, Myc2 antibody, Niard antibody, Nird antibody, cmyc antibody, zc-myc antibody, c-myc II antibody, myc-B antibody, myc2 antibody, myc1 antibody, CMyc antibody, zgc:55680 antibody, CG10798 antibody, D-Myc antibody, DM antibody, DMYc antibody, Dm antibody, Dmel\CG10798 antibody, Dmyc antibody, EG:BACN5I9.1 antibody, anon-WO03040301.171 antibody, bHLHe57 antibody, c-MYC antibody, d-myc antibody, dMYC antibody, dMyc antibody, dMyc1 antibody, da antibody, dm antibody, dm/dMyc antibody, dm/myc antibody, dmyc antibody, dmyc1 antibody, l(1)G0139 antibody, l(1)G0354 antibody, l(1)G0359 antibody, myc antibody, MYC proto-oncogene, bHLH transcription factor antibody, v-myc myelocytomatosis viral oncogene homolog antibody, nucleolar protein 3 (apoptosis repressor with CARD domain) antibody, myelocytomatosis oncogene antibody, MYC proto-oncogene, bHLH transcription factor a antibody, MYC proto-oncogene, bHLH transcription factor L homeolog antibody, MYC proto-oncogene, bHLH transcription factor S homeolog antibody, v-myc myelocytomatosis viral oncogene homolog (avian) antibody, MYC proto-oncogene, bHLH transcription factor b antibody, CG10798 gene product from transcript CG10798-RB antibody, MYC antibody, LOC100136746 antibody, Nol3 antibody, Myc antibody, myca antibody, myc.L antibody, myc.S antibody, mycb antibody
Background
Myc proto-oncogene encodes nuclear DNA-binding phosphoproteins that are involved in the regulation of gene expression and DNA replication during cell growth and differentiation. Myc encodes a protein of 65 kDa which is expressed in almost all normal and transformed cells. The expression correlates with the proliferation state of the cells. Transcription is repressed in quiescent or terminally differentiated cells. Expression of Myc is generally induced after mitogenic stimulation of cells or serum induction. Myc therefore is an important positive regulator of cell growth and proliferation. Myc has been demonstrated also to be a potent inducer of apoptosis when expressed in the absence of serum or growth factors. Apoptosis may serve also as a protective mechanism to prevent tumorigenicity elicited by deregulated Myc expression. Sequences of the Myc oncogene have been highly conserved throughout evolution, from Drosophila to vertebrates
Molecular Weight
60 kDa
Gene ID
4609
NCBI Accession
NP_002458
UniProt
P01106
Pathways
p53 Signaling , Cell Division Cycle , Sensory Perception of Sound , Transition Metal Ion Homeostasis , Mitotic G1-G1/S Phases , Positive Regulation of Endopeptidase Activity , Regulation of Carbohydrate Metabolic Process , Positive Regulation of Response to DNA Damage Stimulus , Warburg Effect
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