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Human Polyclonal POLK Primary Antibody for WB - ABIN1881669
Lone, Townson, Uljon, Johnson, Brahma, Nair, Prakash, Prakash, Aggarwal: Human DNA polymerase kappa encircles DNA: implications for mismatch extension and lesion bypass. in Molecular cell 2007
Show all 5 references for ABIN1881669
Cow (Bovine) Polyclonal POLK Primary Antibody for WB - ABIN2783506
Hile, Eckert: DNA polymerase kappa produces interrupted mutations and displays polar pausing within mononucleotide microsatellite sequences. in Nucleic acids research 2008
Human Monoclonal POLK Primary Antibody for IF, IHC (p) - ABIN565606
Sekimoto, Oda, Kurashima, Hanaoka, Yamashita: Both high-fidelity replicative and low-fidelity Y-family polymerases are involved in DNA rereplication. in Molecular and cellular biology 2015
Polk plays a predominant role in suppressing point mutations by carrying out error-free translesion DNA synthesis and contributes to the prevention of DNA strand breaks.
The structural gap physically accommodates the bulky aromatic adduct and the N-clasp (show CLASRP Antibodies) is essential for the structural integrity and flexibility of Polkappa (show POLL Antibodies) during translesion synthesis.
Polkappa (show POLL Antibodies) accumulates at laser-induced sites of DNA damage.
Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) zeta, and Pol kappa (show POLL Antibodies)
Data suggest that DNA polymerase kappa Polkapp (show POLL Antibodies)a functions in DNA interstrand crosslinks (ICLs) repair in (show APBB1 Antibodies) embryonic fibroblast cells (MEF), especially during the G0/G1 phases.
solution structure of the polymerase kappa-Rev1 complex
results are consistent with the notion that Pol kappa (show POLL Antibodies) is required for accurate translesion DNA synthesis past naturally occurring polycyclic guanine adducts, possibly generated by cholesterol and/or its metabolites.
Polkappa (show POLL Antibodies) plays an important role in suppressing mutations at DNA lesions generated by benzo[a]pyrene, but not UV or x-ray irradiation.
Rev7 competes directly with Pol kappa for binding to the Rev1 C-terminus.
The multiple mouse/human (PolK/POLK) transcripts may encode multiple Polkappa (show POLL Antibodies) isoforms in testis
POLK (show PAPD7 Antibodies) protein polymorphisms may influence the risk of developing breast cancer among Chinese women.
Somatic Mutations in Catalytic Core of POLK (show PAPD7 Antibodies) Reported in Prostate Cancer Alter Translesion DNA Synthesis
POLK (show PAPD7 Antibodies) not only protects cells from genotoxic DNA lesions via DNA polymerase (show POLB Antibodies) activities, but also contributes to genome integrity by acting as a non-catalytic protein against oxidative damage caused by hydrogen peroxide and menadione.
The structural dynamics of DinB1 changes upon substrate binding, noncognate DNA damage prevents the formation of the active conformation of DINB1.
polymorphism of POLK (show PAPD7 Antibodies), an important gene in TLS (show FUS Antibodies), participates in platinum-chemotherapy tolerance and side-effect
Mutations in PIP1 (show PAK1IP1 Antibodies) domain inhibits the stimulation of DNA synthesis by Polkappa (show POLL Antibodies) in the presence of proliferating cell nuclear antigen (show PCNA Antibodies), replication factor C, and replication protein A (show GPR153 Antibodies); and mutations in PIP2 have no effect on PCNA (show PCNA Antibodies)-dependent DNA synthesis.
The truncation R219X was devoid of polymerase activity, and the E419G and Y432S variants showed much lower polymerase activity than wild-type POLK (show PAPD7 Antibodies).
role of the unique Polkappa (show POLL Antibodies) gap and N-clasp (show CLASRP Antibodies) structural features in the fidelity of minor groove lesion processing with extensive molecular modeling and molecular dynamics simulations to pinpoint their functioning in lesion bypass
Phenylalanine 171 is used by PolK (show PAPD7 Antibodies) as a molecular brake for translesional synthesis across benzo[a]pyrene DNA adducts.
DNA polymerase kappa (show PAPD7 Antibodies) rs5744724 polymorphism is associated with lung cancer.
DNA polymerase kappa-dependent DNA synthesis at stalled replication forks is important for CHK1 (show CHEK1 Antibodies) activation.
Data show that DNA polymerase kappa (Pol kappa (show POLL Antibodies)) is essential for replication-independent ICL repair (RIR (show APBB1 Antibodies)) of a site-specific DNA interstrand crosslinks (ICLs) lesion.
pol kappa (show POLL Antibodies) (translesion synthesis TLS4) may assist pol eta (TLS3 or Rad30 (show POLH Antibodies)) in error-free extension during cyclobutane pyrimidine dimer bypass during DNA replication in oocyte extracts.
External and internal DNA-damaging agents continually threaten the integrity of genetic material in cells. Although a variety of repair mechanisms exist to remove the resulting lesions, some lesions escape repair and block the replication machinery. Members of the Y family of DNA polymerases, such as POLK, permit the continuity of the replication fork by allowing replication through such DNA lesions. Each Y family polymerase has a unique DNA-damage bypass and fidelity profile. POLK is specialized for the extension step of lesion bypass (summary by Lone et al., 2007
DNA polymerase kappa
, DNA-directed DNA polymerase kappa
, polymerase (DNA directed) kappa
, DNA polymerase kappa-like
, DNA polymerase sigma
, PAP-associated domain-containing protein 7
, polymerase (DNA directed) sigma
, DINB protein
, DNA damage-inducible protein b
, DinB homolog 1