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Browse our RAN Proteins (RAN)

Full name:
RAN, Member RAS Oncogene Family Proteins (RAN)
On www.antibodies-online.com are 17 RAN, Member RAS Oncogene Family (RAN) Proteins from 8 different suppliers available. Additionally we are shipping RAN Antibodies (149) and RAN Kits (1) and many more products for this protein. A total of 179 RAN products are currently listed.
Synonyms:
AAF30287, ARA24, CG1404, Dmel\CG1404, dran, fc16b04, Gsp1, l(1)G0075, M2, ran, ran-1, Ran/M2, ran10A, RANP1, Rasl2-9-ps, TC4, wu:fc16b04, xran
list all proteins Gene Name GeneID UniProt
RAN 5901 P62826
Rat RAN RAN 84509 P62828
RAN 19384 P62827

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RAN Proteins (RAN) by Origin

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Top referenced RAN Proteins

  1. Human RAN Protein expressed in Escherichia coli (E. coli) - ABIN667788 : Ren, Coutavas, DEustachio, Rush: Effects of mutant Ran/TC4 proteins on cell cycle progression. in Molecular and cellular biology 1994 (PubMed)
    Show all 2 references for ABIN667788

More Proteins for RAN Interaction Partners

Xenopus laevis RAN, Member RAS Oncogene Family (RAN) interaction partners

  1. This study identifies TPX2 as the only direct RanGTP target and NEDD1 (show NEDD1 Proteins) as the only Aurora A (show AURKA Proteins) substrate essential for the activation of the RanGTP-dependent microtubule nucleation pathway.

  2. Experiments in Xenopus assembly extracts with M9M, a superaffinity nuclear localization sequence that displaces cargoes bound by transportin, or TLB, a mutant transportin that can bind cargo and RanGTP simultaneously, support direct inhibition.

  3. Examination of H1 histones reveals isoform-specific regulation by Cdk1 (show CDK1 Proteins) and RanGTP

  4. Data show that importin-beta (show KPNB1 Proteins) binds to Apc (show APC Proteins) and negatively regulates the MT-assembly and spindle-promoting activity of Apc (show APC Proteins) in a Ran-regulatable manner.

  5. results demonstrate that distinctly from its role in spindle assembly, RanGTP maintains spindle microtubules in anaphase through the local activation of ISWI (show SMARCA5 Proteins) and that this is essential for proper chromosome segregation

Fruit Fly (Drosophila melanogaster) RAN, Member RAS Oncogene Family (RAN) interaction partners

  1. the Canoe Ras-association (RA) domains directly bind RanGTP

  2. Knockdown of the small G protein Ran, which is essential for nuclear transport, leads to an arrest of EcR in the cytoplasm, but does not prevent efficient nuclear import of the most important heterodimerization partner of EcR, ultraspiracle (Usp).

  3. results demonstrate that distinctly from its role in spindle assembly, RanGTP maintains spindle microtubules in anaphase through the local activation of ISWI (show SMARCA5 Proteins) and that this is essential for proper chromosome segregation

  4. gtpase ran localizes around the microtubule spindle in vivo during mitosis in Drosophila embryos

  5. anillin (show ANLN Proteins) and Peanut are involved in pseudocleavage furrow ingression in syncytial embryos, a process that is regulated by Ran

Human RAN, Member RAS Oncogene Family (RAN) interaction partners

  1. FGF2 (show FGF2 Proteins) nuclear translocation is regulated by Karyopherin-beta2 and Ran GTPase in human glioblastoma cells

  2. Enterovirus 71-induced downregulation of miR (show MLXIP Proteins)-197 expression increased the expression of RAN, which supported the nuclear transport of the essential viral proteins 3D/3CD and host protein hnRNP K (show HNRNPK Proteins) for viral replication.

  3. Inter-cellular transport of ran GTPase

  4. Data show that RNA-binding protein (show PTBP1 Proteins) LIN28B (show LIN28B Proteins) coordinates the expression of the oncogene (show RAB1A Proteins) RAN protein and aurora A kinase (AURKA (show AURKA Proteins)) in neuroblastoma (show ARHGEF16 Proteins).

  5. Elevated metaphase RanGTP levels use Ubr5 to couple overall chromosome congression to SAC (show ADCY10 Proteins) silencing.

  6. Data show that importin-beta (show KPNB1 Proteins) (impbeta) alters the nuclear pore's permeability in a Ran-dependent manner, suggesting that impbeta is a functional component of the nuclear pore complex (NPC (show NPC1 Proteins)).

  7. RAN nucleo-cytoplasmic transport and mitotic spindle assembly partners XPO7 and TPX2 (show TPX2 Proteins) have roles in serous epithelial ovarian cancer

  8. comparison of the GTPase reaction of the slower hydrolyzing GTPase Ran with Ras

  9. Ran silencing did not affect the A375 invasive capability, while it was enhanced in 526 cells, suggesting that Ran knockdown, by AurkA (show AURKA Proteins) down-regulation, resulted in a Ran-independent enhanced melanoma cell invasion.

  10. stress can disrupt the Ran gradients through RCC1 (show RCC1 Proteins)-dependent and RCC1 (show RCC1 Proteins)-independent mechanisms

Mouse (Murine) RAN, Member RAS Oncogene Family (RAN) interaction partners

  1. Data suggest Ran activation by RanBP1 (show RANBP1 Proteins) in macrophages promotes Legionella phagosome formation and phagocytosis; LegG1 functions as bacterial Ran activator, localizes to phagosomes, and promotes microtubule stabilization, phagocytosis, and replication.

  2. Augmented expression of Ran in progranulin (show GRN Proteins)-deficient neurons restores nuclear TDP-43 (show TARDBP Proteins) levels and improves their survival.

  3. Reduction in Ran levels causes cytoplasmic decrease and nuclear accumulation of importin alpha (show KPNA4 Proteins) leading to cellular senescence in normal cells.

  4. a novel connection between the hyper-activation of the small GTPase Ran and the matricellular protein SMOC-2 (show SMOC2 Proteins) that has important consequences for oncogenic transformation.

  5. A critical function of RanBP2 is to capture recycling RanGTP-importin-beta (show KPNB1 Proteins) complexes at cytoplasmic fibrils to allow for adequate classical nuclear localization signal-mediated cargo import.

  6. Downregulation of the Ran GTPase effector RanBP1 (show RANBP1 Proteins) is required for nuclear reorganisation.

  7. Activation of the Ran GTPase is subject to growth factor regulation and can give rise to cellular transformation.

  8. intracellular Ran protein levels control the nuclear retention for selective transcription factors such as c-Jun (show JUN Proteins) and c-Fos of AP-1 (show JUN Proteins), which is known to be critical in T cell activation and proliferation and lymphokine (show IL2 Proteins) secretion.

  9. expression of Ran/M1 (show TLR4 Proteins) and Ran/M2 increased in pachytene spermatocytes with progressive transcript accumulation until they reached the round spermatid stage, in the seminiferous epithelium of adults

  10. RanGDP is regulated by phosphorylation and regulated by NTF2 (show NUTF2 Proteins)

RAN Protein Profile

Protein Summary

RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.

Alternative names and synonyms associated with RAN

  • RAN, member RAS oncogene family (ran)
  • RAN, member RAS oncogene family (RAN)
  • CG1404 gene product from transcript CG1404-RA (ran)
  • RAN, member RAS oncogene family (ran-1)
  • RAN, member RAS oncogene family (Ran)
  • RAS-like, family 2, locus 9 (Rasl2-9)
  • ras-related nuclear protein (ran)
  • AAF30287 protein
  • ARA24 protein
  • CG1404 protein
  • Dmel\CG1404 protein
  • dran protein
  • fc16b04 protein
  • Gsp1 protein
  • l(1)G0075 protein
  • M2 protein
  • ran protein
  • ran-1 protein
  • Ran/M2 protein
  • ran10A protein
  • RANP1 protein
  • Rasl2-9-ps protein
  • TC4 protein
  • wu:fc16b04 protein
  • xran protein

Protein level used designations for RAN

GTP-binding nuclear protein Ran , GTPase Ran , ras-like protein TC4 , ras-related nuclear protein , RAN, member RAS oncogene family , ran GTP-binding protein , CG1404-PA , CG1404-PB , Ran GTPase , ran-PA , ran-PB , OK/SW-cl.81 , RanGTPase , androgen receptor-associated protein 24 , guanosine triphosphatase Ran , member RAS oncogene family , RAN, member RAS oncogene family pseudogene 1 , GTP-binding nuclear protein Ran, testis-specific isoform , RAS-like, family 2, locus 9, pseudogene

GENE ID SPECIES
448091 Xenopus (Silurana) tropicalis
452414 Pan troglodytes
100173539 Pongo abelii
100189578 Xenopus laevis
100302079 Ovis aries
100499482 Canis lupus familiaris
44072 Drosophila melanogaster
379874 Xenopus laevis
5901 Homo sapiens
540457 Bos taurus
84509 Rattus norvegicus
442976 Canis lupus familiaris
19384 Mus musculus
396193 Gallus gallus
397655 Sus scrofa
19428 Mus musculus
30572 Danio rerio
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