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Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc.
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Human Polyclonal CD98LC Primary Antibody for IHC (p), WB - ABIN2472893
Fisher, Shivde, Teixera, Grainer: The F. response--a clinically useful physiological parameter for the evaluation of radicular injury. in Electromyography and clinical neurophysiology 1980
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LAT1 (show LAT Antibodies)-NAD+-SIRT1 (show SIRT1 Antibodies) signaling is activated in tumor tissues of patients with non-small cell lung cancer; NAD+ synthesis regulates the SIRT1 (show SIRT1 Antibodies)-FOXO1 (show FOXO1 Antibodies) apoptotic pathway in response to NQO1 (show NQO1 Antibodies)
Thus, our results indicated that lncRNA-PVT1-5 may function as a competing endogenous RNA (ceRNA) for miR (show MLXIP Antibodies)-126 to promote cell proliferation by regulating the miR (show MLXIP Antibodies)-126/SLC7A5 (show SLC7A5 Antibodies) pathway, suggesting that lncRNA-PVT1-5 plays a crucial role in lung cancer progression and lncRNA-PVT1-5/miR (show MLXIP Antibodies)-126/SLC7A5 (show SLC7A5 Antibodies) regulatory network may shed light on tumorigenesis in lung cancer.
Study showed that a positive [18F] FDOPA uptake in PET was associated with a minimal threshold of LAT1 (show LAT Antibodies) expression, but did not find a linear correlation between intensity of [18F] FDOPA uptake and level of LAT1 (show LAT Antibodies) expression.
this study shows that IL-2 (show IL2 Antibodies)-induced expression of CD98 (show SLC3A2 Antibodies) is a prerequisite for NKG2D (show KLRK1 Antibodies)-mediated activation of NK cells
These results demonstrate a novel fundamental role of LAT1 (show LAT Antibodies) to support the protein expression of 4F2hc (show SLC3A2 Antibodies) via a chaperone-like function in chorionic trophoblasts.
MTA1 (show MTA1 Antibodies) expression was positively correlated with LAT1 (show LAT Antibodies) (p=0.013) and CD34 (show CD34 Antibodies) (p=0.034) expression, but not with Ki-67 (show MKI67 Antibodies) (p=0.078). MTA1 (show MTA1 Antibodies) shows promise as a diagnostic and prognostic marker in esophageal cancer, and we anticipate that the gene will also prove to be a good therapeutic target.
LAT1 (show LAT Antibodies) overexpression was common in Brain Metastases and was specific for Brain Metastases as compared to healthy brain. These results could explain the specific Brain Metastases uptake on PET-AA.
LAT1 (show LAT Antibodies) and LAT2 (show LAT2 Antibodies) were overexpressed in both pheochromocytoma and medullary thyroid carcinoma by comparison with normal tissues.
he findings in this study indicate a regulation relationship between CRKL (show CRKL Antibodies) and SLC7A5 (show SLC7A5 Antibodies), and provide useful evidence for gastric cancer therapeutic strategies.
Study shows that the solute carrier (show SERTAD2 Antibodies) transporter 7a5 (show MACC1 Antibodies) (SLC7A5 (show SLC7A5 Antibodies)), a large neutral amino acid transporter (show SLC6A19 Antibodies) localized at the blood brain barrier (BBB (show ALMS1 Antibodies)), has an essential role in maintaining normal levels of brain branched-chain amino acids; also identified several patients with autistic traits and motor delay carrying deleterious homozygous mutations in the SLC7A5 (show SLC7A5 Antibodies) gene.
Slc3a2 (show SLC3A2 Antibodies) is required for branched-chain amino-acid-dependent maintenance of Treg cells.
CD98hc (show SLC3A2 Antibodies) expression in vascular smooth muscle cells contributes to the formation of plaques that are morphologically more stable, and thereby protects against atherothrombosis.
These results demonstrate a novel fundamental role of LAT1 (show SLC7A5 Antibodies) to support the protein expression of 4F2hc (show SLC3A2 Antibodies) via a chaperone-like function in chorionic trophoblasts.
CD98 (show SLC3A2 Antibodies) is required for endothelial cell growth. CD98 (show SLC3A2 Antibodies)-specific reagents could have a dual anticancer effect: directly by inhibiting tumor cell proliferation and indirectly by preventing tumor angiogenesis
Taken together, our data indicate that T cell-specific deletion of CD98hc (show SLC3A2 Antibodies) can contribute to the prevention of GvHD development due to the attenuation of lymphocyte migration and by increasing the generation of Treg cells.
data establish CD98hc (show SLC3A2 Antibodies) as a master protective gene at the cross-road of redox control and AA availability, making it a relevant therapeutic target in cancer.
ubiquitylation and the resulting downregulation of CD98 (show SLC3A2 Antibodies) can limit cell proliferation and clonal expansion.
CD98hc (show SLC3A2 Antibodies) mediated this stiffness sensing by increasing Rho kinase (show ROCK2 Antibodies) (ROCK) activity.
Mice lacking CD98hc (show SLC3A2 Antibodies) in B cells are protected from experimental autoimmune encephalomyelitis.
CD98 heavy chain (show SLC3A2 Antibodies) is crucial for T cell-mediated autoimmune colitis. CD98 heavy chain (show SLC3A2 Antibodies) deficiency in T cells is involved in increasing induced regulatory T cells.
Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood- brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L- leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts.
, 4F2 light chain
, CD98 light chain
, L-type amino acid transporter 1
, integral membrane protein E16
, large neutral amino acids transporter 1
, large neutral amino acids transporter small subunit 1
, sodium-independent neutral amino acid transporter LAT1
, solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
, solute carrier family 7 member 5
, y+ system cationic amino acid transporter
, 4F2 cell-surface antigen heavy chain
, CD98 antigen
, CD98 heavy chain
, antigen identified by monoclonal antibodies 4F2
, type II transmembrane protein