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Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N- acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains (By simi. Additionally we are shipping Exostoses (Multiple)-Like 2 Proteins (8) and Exostoses (Multiple)-Like 2 Kits (4) and many more products for this protein.
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Data show that exostosin-like 2 (EXTL2) controls fibroblast growth factor 2 (FGF2) signaling through regulation of heparan sulfate biosynthesis.
EXTL2 controls liver regeneration and aortic calcification through xylose kinase-dependent regulation of glycosaminoglycan biosynthesis.[review]
EXTL2-mediated regulation of glycosaminoglycans synthesis is important for tissue regeneration processes following liver injury.
EXTL2 functions to suppress GAG biosynthesis that is enhanced by a xylose kinase and the EXTL2-dependent mechanism that regulates GAG biosynthesis might be a "quality control system" for proteoglycans
crystal structure of EXTL2
Lysosomal glycosaminoglycan levels in mucopolysaccharidosis are reduced by EXTL2 gene silencing.
donor binding appears to undergo two distinct steps, beginning with the N-acetyl group expelling water from the donor- enzyme complex into the bulk solvent followed by positioning of the donor into the binding site for interactions with the enzyme
Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N- acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains (By similarity).
EXT-related protein 2
, alpha-1,4-N-acetylhexosaminyltransferase EXTL2
, alpha-GalNAcT EXTL2
, exostoses-like 2
, exostosin-like 2
, exotoses (multiple)-like 2
, glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
, exostoses (multiple)-like 2
, processed exostosin-like 2