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QPCT encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. Additionally we are shipping QPCT Proteins (15) and QPCT Kits (13) and many more products for this protein.
Showing 10 out of 60 products:
Human Polyclonal QPCT Primary Antibody for ELISA, WB - ABIN565166
Morawski, Hartlage-Rübsamen, Jäger, Waniek, Schilling, Schwab, McGeer, Arendt, Demuth, Rossner: Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease. in Acta neuropathologica 2010
Show all 4 Pubmed References
Human Polyclonal QPCT Primary Antibody for WB - ABIN2565834
Morawski, Schilling, Kreuzberger, Waniek, Jäger, Koch, Cynis, Kehlen, Arendt, Hartlage-Rübsamen, Demuth, Roßner: Glutaminyl cyclase in human cortex: correlation with (pGlu)-amyloid-? load and cognitive decline in Alzheimer's disease. in Journal of Alzheimer's disease : JAD 2014
Human Polyclonal QPCT Primary Antibody for WB - ABIN525428
Valenti, Bolognin, Zanatta, Donatelli, Innamorati, Pampanin, Zanusso, Zatta, Dalle Carbonare: Increased glutaminyl cyclase expression in peripheral blood of Alzheimer's disease patients. in Journal of Alzheimer's disease : JAD 2013
Human Polyclonal QPCT Primary Antibody for IHC, IHC (p) - ABIN4314698
Guo, He, Liu, Zhang, Lv, Zeng, Gu, Wu: Identification and Epigenetic Analysis of a Maternally Imprinted Gene Qpct. in Molecules and cells 2015
the genetic risk of QPCT gene for schizophrenia also exists in the Han Chinese population.
observations provide evidence for an involvement of QC in Alzheimer's disease pathogenesis and cognitive decline by QC-catalyzed pGlu-Abeta (show APP Antibodies) formation
this study demonistrated that QPCT mRNAand protein from mononuclear cells correlated with theseverity of dementia.
Upregulation of QPCT expression is associated with thyroid carcinomas.
The resilts of this studt provided histopathological evidence for QC being a prerequisite for pE-Abeta (show APP Antibodies) pathology in vivo and further underline the therapeutic potential of QC inhibition in Alzheimer Disease.
Upon binding to PBD150, a large loop movement in gQC (show QPCTL Antibodies) allows the inhibitor to be tightly held in its active site primarily by hydrophobic interactions.
This study demonstrated that glutaminyl cyclase expression and pE-Abeta (show APP Antibodies) formation in subcortical brain regions( Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert) affected in Alzheimer's disease.
Human isoQC (show QPCTL Antibodies)proteins displayed a broad substrate specificity and preference for hydrophobic substrates, similar to the related QC.
Functional expression of human glutaminyl cyclase in Pichia pastoris reveals the presence of a disulfide bond with an important role in the stabilization of active protein structure.
human glutaminyl cyclase is a metal-dependent transferase
Authors identified a placenta-specific imprinted gene Qpct. Results show that Qpct is widely expressed during early embryonic development and can be detected in the telencephalon, midbrain, and rhombencephalon at E9.5-E11.5.
co-regulation of the enzyme glutaminyl cyclase and its substrate TRH (show TRH Antibodies) was reflected by a co-induction of both proteins in reactive astrocytes in proximity of Abeta (show APP Antibodies) deposits
This study provide a thorough comparative characterization of the glutaminyl cyclases QC and isoQC (show QPCTL Antibodies) in defined brain regions of different inbred and outbred mouse strains
Glutaminyl cyclase in a mouse knockout model has a role in hypothyroidism but not hypogonadism
Murine isoQC (show QPCTL Antibodies) proteins displayed a broad substrate specificity and preference for hydrophobic substrates, similar to the related QC.
Results describe the expression of glutaminyl cyclase throughout the mouse brain during early postnatal development.
The observations of this study indicated that brain ischemia might be a pathogenic factor of alzheimer disease through increasing BACE1 (show BACE Antibodies), cathepsin B (show CTSB Antibodies), and glutaminyl cyclase.
This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase.
, glutaminyl cyclase
, glutaminyl-tRNA cyclotransferase
, glutamyl cyclase
, glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
, glutaminyl-peptide cyclotransferase
, glutaminyl-peptide cyclotransferase-like 1
, glutaminyl-peptide cyclotransferase L homeolog