Hematopoietic Cell Signal Transducer Proteins (HCST)

HCST encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. Additionally we are shipping HCST Antibodies (31) and HCST Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HCST 10870 Q9UBK5
HCST 23900 Q9QUJ0
Rat HCST HCST 474146 Q6X9T8
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Top HCST Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
Human Cells Human Fc Tag 100 μg Log in to see 20 to 21 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days

HCST Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Hematopoietic Cell Signal Transducer (HCST) Interaction Partners

Zebrafish Hematopoietic Cell Signal Transducer (HCST) interaction partners

  1. The structure of the adaptor protein dap10 has been identified in the zebrafish genome.

Human Hematopoietic Cell Signal Transducer (HCST) interaction partners

  1. These results suggest that NKG2D (show KLRK1 Proteins)-DAP10 endocytosis represents a means to decrease cell surface receptor abundance, as well as to control signaling outcome in cytotoxic lymphocytes.

  2. findings indicate that the functional interaction between RAGE (show AGER Proteins) and DAP10 coordinately regulates S100A8 (show S100A8 Proteins)/A9-mediated survival and/or apoptotic response of keratinocytes

  3. TGF-beta1 (show TGFB1 Proteins) may reduce the expression of NKG2D (show KLRK1 Proteins)/DAP10 and 2B4 (show CD244 Proteins)/SAPin patients with hepatitis B.

  4. HMBOX1 (show HMBOX1 Proteins) negatively regulates the expression of NKG2D (show KLRK1 Proteins) and the activation of the NKG2D (show KLRK1 Proteins)/DAP10 signaling pathway in NK cells.

  5. Other gamma(c) cytokines act similarly to IL-2 (show IL2 Proteins) in up-regulating DAP10 expression and NKG2D (show KLRK1 Proteins)-DAP10 surface expression.

  6. TGF-BETA1 (show TGFB1 Proteins) down-modulates surface NKG2D (show KLRK1 Proteins) expression by controlling the transcriptional and translational levels of DAP10.

  7. A transgenic mouse model demonstrates that induction of tolerance in Ly49H-positive natural killer (NK) cells by chronic exposure to virus-encoded ligand m157 requires signaling through the Ly49H adaptor protein DAP12 (show TYROBP Proteins), not the DAP10 adaptor protein.

  8. NKG2D (show KLRK1 Proteins)-DAP10 triggers human NK cell-mediated killing via a Syk (show SYK Proteins)-independent regulatory pathway.

  9. both activated and expanded CD8 (show CD8A Proteins)+ T cells and NK cells use DAP10 for cytolysis

  10. Downstream targets of DAP10 and DAP12 (show TYROBP Proteins) are constitutively activated in large granular lymphocyte leukemia cells, and expression of dominant-negative DAP10 and DAP12 (show TYROBP Proteins) dramatically reduces their lytic capacity.

Mouse (Murine) Hematopoietic Cell Signal Transducer (HCST) interaction partners

  1. Adoptive transfer of murine T cells expressing a chimeric-PD1 (show PDCD1 Proteins)-Dap10 receptor may induce a preferential cytokine profile and T-cell differentiation phenotype for anti-lymphoma therapies.

  2. Rat and mouse CD94 (show KLRD1 Proteins)/NKG2C (show KLRC2 Proteins) heterodimers bind efficiently to both DAP12 (show TYROBP Proteins) and DAP10; this binding is critically dependent on the transmembrane lysine residue of CD94 (show KLRD1 Proteins).

  3. contributes to CD8 (show CD8A Proteins)(+) T cell-mediated cytotoxic effector mechanisms during Mycobacterium tuberculosis infection

  4. demonstrate a previously uncharacterized interaction of SHIP1 (show INPP5D Proteins) with DAP12 (show TYROBP Proteins) that limits TREM2 (show TREM2 Proteins)- and DAP12 (show TYROBP Proteins)-dependent signaling and identify a mechanism through which SHIP1 (show INPP5D Proteins) regulates key ITAM-containing receptors by blocking the binding and activation of PI3K

  5. selective associations with DAP10 determine stimulatory versus costimulatory activity of NKG2D (show KLRK1 Proteins)

  6. Differential requirements for Vav (show VAV1 Proteins) proteins in DAP10- and ITAM-mediated NK cell cytotoxicity.

  7. The importance of Fcgr3 (show CD16 Proteins)/Cd3z (show CD247 Proteins), Hcst, and Tyrobp (show TYROBP Proteins) in the activation of NK cells in the uterus of pregnant mice is reported.

  8. Review of immune reactions against syngeneic tumors reveals an important physiological role of DAP10 adapter protein (show GRB10 Proteins) signaling in maintaining tolerance to self, by controlling the development and activation threshold of autoreactive T cells.

  9. DAP10 signaling is involved in adjusting the activation threshold and generation of natural killer T cells and regulatory T cells to avoid autoreactivity, but it also modulates antitumor mechanisms.

  10. improved rejection of B16 melanomas in DAP10-deficient mice

Cow (Bovine) Hematopoietic Cell Signal Transducer (HCST) interaction partners

HCST Protein Profile

Protein Summary

This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms.

Gene names and symbols associated with HCST

  • hematopoietic cell signal transducer (HCST)
  • hematopoietic cell signal transducer (hcst)
  • hematopoietic cell signal transducer (Hcst)
  • Dap10 protein
  • HCST protein
  • KAP10 protein
  • PIK3AP protein

Protein level used designations for HCST

hematopoietic cell signal transducer , dap10 , DNAX-activation protein 10 , kinase assoc pro of ~10kDa , kinase assoc protein , membrane protein DAP10 , phosphoinositide-3-kinase adaptor protein , transmembrane adapter protein KAP10 , putative membrane adaptor molecule , immunoreceptor DAP10

612627 Canis lupus familiaris
748082 Pan troglodytes
100101460 Danio rerio
10870 Homo sapiens
23900 Mus musculus
474146 Rattus norvegicus
767892 Bos taurus
397267 Sus scrofa
574152 Macaca mulatta
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