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May have a role in the regulation of spermatogenesis.. Additionally we are shipping PD-1 Proteins (93) and PD-1 Kits (24) and many more products for this protein.
Showing 10 out of 659 products:
Human Polyclonal PD-1 Primary Antibody for BR, CyTOF - ABIN5012979
Wan, Nie, Liu, Feng, He, Xu, Zhang, Dong, Zhang: Aberrant regulation of synovial T cell activation by soluble costimulatory molecules in rheumatoid arthritis. in Journal of immunology (Baltimore, Md. : 1950) 2007
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Human Polyclonal PD-1 Primary Antibody for ELISA (Detection), FACS - ABIN4899871
Sakthivel, Ramanujam, Wang, Pirskanen, Lefvert: Programmed Death-1: from gene to protein in autoimmune human myasthenia gravis. in Journal of neuroimmunology 2008
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Human Monoclonal PD-1 Primary Antibody for BR, FACS - ABIN2689142
Bennett, Luxenberg, Ling, Wang, Marquette, Lowe, Khan, Veldman, Jacobs, Valge-Archer, Collins, Carreno: Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses. in Journal of immunology (Baltimore, Md. : 1950) 2003
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Mouse (Murine) Monoclonal PD-1 Primary Antibody for BR, FACS - ABIN2689141
Nishimura, Agata, Kawasaki, Sato, Imamura, Minato, Yagita, Nakano, Honjo: Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4-CD8-) thymocytes. in International immunology 1997
Show all 7 Pubmed References
Human Polyclonal PD-1 Primary Antibody for IHC, ELISA - ABIN1002980
Holling, Schooten, van Den Elsen: Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men. in Human immunology 2004
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Human Polyclonal PD-1 Primary Antibody for IHC, ELISA - ABIN1002981
Ishida, Agata, Shibahara, Honjo: Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. in The EMBO journal 1992
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Human Monoclonal PD-1 Primary Antibody for ICC, FACS - ABIN438813
Dorrell, Abraham, Lanxon-Cookson, Canaday, Streeter, Grompe: Isolation of major pancreatic cell types and long-term culture-initiating cells using novel human surface markers. in Stem cell research 2009
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Mouse (Murine) Polyclonal PD-1 Primary Antibody for CyTOF, FACS - ABIN4899873
Kasagi, Kawano, Okazaki, Honjo, Morinobu, Hatachi, Shimatani, Tanaka, Minato, Kumagai: Anti-programmed cell death 1 antibody reduces CD4+PD-1+ T cells and relieves the lupus-like nephritis of NZB/W F1 mice. in Journal of immunology (Baltimore, Md. : 1950) 2010
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Human Polyclonal PD-1 Primary Antibody for IF (p), IHC (p) - ABIN735608
Zhang, Niyazi, Hong, Tuluwengjiang, Zhang, Zhang, Su, Bao: Effect of EBI3 on radiation-induced immunosuppression of cervical cancer HeLa cells by regulating Treg cells through PD-1/PD-L1 pathway. in Tumour biology 2017
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Human Monoclonal PD-1 Primary Antibody for FACS - ABIN2479653
Ochonisky, Chosidow, Kuentz, Man, Fraitag, Pelisse, Revuz: Cogan's syndrome. An unusual etiology of urticarial vasculitis. in Dermatologica 1992
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These results demonstrate the involvement of sPD (show HOXD13 Antibodies)-1 in the disease course of chronic HBV infection and indicate the potential to apply sPD (show HOXD13 Antibodies)-1 as a biomarker for differentiating IT from other phases and HCC (show FAM126A Antibodies) from other disease conditions in chronic HBV infection.
summarizes the latest research on PD-1 in infectious diseases and discusses its role in acute and chronic viral infection[review]
Our study demonstrates a cross-talk between PARPi and tumor-associated immunosuppression and provides evidence to support the combination of PARPi and PD-L1 (show CD274 Antibodies) or PD-1 immune checkpoint blockade as a potential therapeutic approach to treat breast cancer
Results show that high programmed cell death 1 (PDCD1, PD-1)methylation (mPDCD1) was associated with a significantly shorter overall survival after surgical resection.
Suggest that genetic polymorphisms of PD-1 function as sex-dependent risk factors for development of acute rejection in an Iranian kidney transplant population.
downregulation in PD-1 inhibitory signaling in RA could be attributed to increased serum sPD (show HOXD13 Antibodies)-1 and decreased synovial tissue PD-L1 (show CD274 Antibodies) levels
PD1 polymorphisms are associated with susceptibility to chronic hepatitis B infection in the Chinese population.
PD-1 seems to correlate with disease progression in epitheliotropic T cell dyscrasias ranging from minimal staining in prelymphomatous dyscrasias to significant staining in mycosis fungoides
in some tumor types, PD-L2 (show PDCD1LG2 Antibodies) expression is more closely linked to Th1 (show TH1L Antibodies)/IFNG (show IFNG Antibodies) expression and PD-1 and CD8 (show CD8A Antibodies) signaling than PD-L1 (show CD274 Antibodies)
Although mutational and immunologic differences have been proposed as the primary determinants of heterogeneous response/resistance to targeted therapies and immunotherapies, respectively, differential lesional gene expression profiles may also dictate anti-PD-1 outcomes
An examination of the mechanisms of immunity behind this long-term protection in PD-1 knockout mice showed a key role for parasite-specific CD8 (show CD8A Antibodies)(+) T cells even when CD4 (show CD4 Antibodies)(+) T cells and B cells responded to re-infection.
To test the in vivo activity of REGN2810, which does not cross-react with murine PD-1, knock-in mice were generated to express a hybrid protein containing the extracellular domain of human PD-1, and transmembrane and intracellular domains of mouse PD-1
The combination of tumor vaccination to induce high avidity tumor specific T cell responses and PD-1 blockade synergises to provide tumor therapy and 85% survival in the aggressive B16 melanoma model.
Blockade of PD-1 with monoclonal antibody may be an effective treatment during the postoperative period for restoring surgery-induced immunosuppression.
Data suggest that genetic or environmental factors that even moderately affect the expression of both PD-1 and FoxP3 (show FOXP3 Antibodies) can cause life-threatening autoimmune diseases by disrupting the T-cell homeostasis.
Data (including data from studies in transgenic/knockout mice) suggest that T-cell expression of Mirn155 is required to limit melanoma growth; miR (show MLXIP Antibodies)-155, Pdcd1, Pdcd1l1 (show CD274 Antibodies), and Ctla4 (show CTLA4 Antibodies) appear to regulate overlapping pathways promoting antitumor immunity. [Mirn155 = microRNA 155; Pdcd1 = programmed cell death 1 protein; Pdcd1l1 (show CD274 Antibodies) = programmed cell death 1 ligand 1 (show CD274 Antibodies) protein; Ctla4 (show CTLA4 Antibodies) = cytotoxic T-lymphocyte-associated protein 4 (show CTLA4 Antibodies)]
PD-1 plays a vital role in brain inflammation via regulation of Fgl-2 (show FGL2 Antibodies) after ICH (show ACE Antibodies), and that manipulation of PD-1 might be a promising therapeutical target in ICH (show ACE Antibodies).
We identified PD-1 to be specifically expressed in PLZF (show ZBTB16 Antibodies)(+) ILCp and revealed that the timing and order of expression of the transcription factors NFIL3 (show NFIL3 Antibodies), ID2, and TCF-1 (show HNF1A Antibodies) was critical. Importantly, induction of ILC (show CCL27 Antibodies) lineage commitment required only transient expression of NFIL3 (show NFIL3 Antibodies) prior to ID2 and TCF-1 (show HNF1A Antibodies) expression.
The identification of the role for PD-1 in regulating B cell-dependent antitumor immunity to Tn antigen highlights an opportunity to develop new therapeutic strategies targeting tumor-associated carbohydrate antigens
These findings suggest that PD-1 pathway blockade may reverse adaptive immune resistance following cyclic dinucleotide treatment, enhancing both local and systemic antitumor immunity.
Data show that CTLA-4 (show CTLA4 Antibodies)(+)PD-1(-) memory CD4 (show CD4 Antibodies)(+) T cells, which share phenotypic markers with regulatory T cells, were enriched in SIV DNA in blood, lymph nodes (LN), spleen, and gut (show GUSB Antibodies), and contained replication-competent and infectious virus.
Compared to before immunosuppression, PD-1 expression increased at reactivation. Increased T cells before zoster is likely due to virus reactivation.
A PD-1(high) phenotype is associated with accelerated in vivo CD8 (show CD8A Antibodies) T cell turnover in SIV-infections, especially within the SIV-specific CD8 (show CD8A Antibodies) T cell pool.
High levels of PD-1 expression on CD4 (show CD4 Antibodies)(+) T cells in lymph nodes of rhesus macaques can serve as a valuable marker to identify T follicular helper cells.
Data indicate that PD-1 expression is increased as a result of T cell activation during a primary immune response as well as during persistent immune activation in macaques.
PD-1 can serve as a sensitive indicator of persistent, low-level virus replication
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.
programmed cell death protein 1
, protein PD-1
, programmed cell death 1
, programmed death 1