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Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. Additionally we are shipping Protein Kinase D3 Antibodies (117) and many more products for this protein.
Showing 10 out of 11 products:
The enriched pathway analysis reveals that PRKD3 regulates pathways contributing to multiple cancer related events, including cell cycle, migration and others.
None of the Polymorphous low-grade adenocarcinoma (PLGA) lacking PRKD1 (show PRKD1 Proteins) somatic mutations or PRKD gene family rearrangements harboured somatic mutations in the kinase domains of the PRKD2 (show PKD2 Proteins) or PRKD3 genes.
This study discovered and characterized a novel, highly conserved N-terminal domain, comprising 92 amino acids, which mediates dimerization of Protein Kinase D (PKD) isoforms, PKD1 (show PKD1 Proteins), PKD2 (show PKD2 Proteins), and PKD3 monomers.
Studies indicate that the loss of protein kinase D PKD1 is thought to promote invasion and metastasis, while PKD2 (show PKD2 Proteins) and upregulated PKD3 to be positive regulators of proliferation.
Loss of PKD2 (show PKD2 Proteins) enhanced KC proliferative potential while loss of PKD3 resulted in a progressive proliferation defect, loss of clonogenicity and diminished tissue regenerative ability.
for the first time, PKD3 is implicated in the transcription activation of latent HIV-1 provirus, and our results revealed a molecular mechanism of prostratin-induced HIV-1 transcription via PKCepsilon (show PRKCE Proteins)/PKD3/NF-kappaB (show NFKB1 Proteins) signaling pathway.
Activation of PKD2 (show PKD2 Proteins) and further increase of PKD3 activity leads to additional phosphorylation and inhibition of endogenous phosphatase slingshot 1L (show SSH1 Proteins).
PKD3 in TNBC cells provides a molecular connection between the Golgi and endolysosomal compartments to enhance proliferative mTORC1-S6K1 (show RPS6KB1 Proteins) signaling.
PKD3 negatively regulates human airway epithelial barrier formation and integrity through down-regulation of claudin-1 (show CLDN7 Proteins), which is a key component of tight junctions.
PKD3 may contribute to the malignant progression of prostate cancer cells through negative regulation of MMP-7 (show MMP7 Proteins) expression.
These data provide new insights of a specific PKD3 signaling pathway by identifying a new function, which has not been identified before.
Erythropoietin (show EPO Proteins) regulates GATA1 (show GATA1 Proteins) through protein kinase D (show PRKD1 Proteins) activation, promoting histone deacetylase 5 (show HDAC5 Proteins) dissociation from GATA1 (show GATA1 Proteins), and subsequent GATA1 (show GATA1 Proteins) acetylation.
These data validate PKD3 as a promising therapeutic target in prostate cancer and shed light on the role of secreted tumor-promoting factors in prostate cancer progression.
PKCnu is an important component of signaling pathways downstream from novel PKC enzymes after B-cell receptor engagement
the catalytic activity of PKD3 may regulate its nuclear import through autophosphorylation and/or interaction with another protein
PKD3 is increasingly expressed in neuronal as well as in the supporting connective tissue and in skeletal muscles
reveal a novel distinction between the exocrine and endocrine cells of the pancreas and further identify PKD3 as a signaling molecule that promotes hormone-stimulated amylase (show AMY Proteins) secretion
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. This kinase can be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phopholipase C gamma and the involvement of other PKC family members.
protein kinase C nu type
, protein kinase C, nu
, protein kinase EPK2
, protein-serine/threonine kinase
, serine/threonine-protein kinase D3
, protein kinase D3
, serine/threonine-protein kinase D3-like