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ROBO3 is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. Additionally we are shipping ROBO3 Proteins (8) and ROBO3 Kits (3) and many more products for this protein.
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Human Polyclonal ROBO3 Primary Antibody for ELISA, WB - ABIN190793
Kato, Takeuchi, Sato, Yoneyama, Yamamoto, Matsui, Uematsu, Jung, Kawai, Ishii, Yamaguchi, Otsu, Tsujimura, Koh, Reis e Sousa, Matsuura, Fujita, Akira: Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. in Nature 2006
Show all 2 Pubmed References
confirmed that ROBO3 increases with clinical grade and miR (show MLXIP Antibodies)-383 expression is inversely correlated to that of ROBO3
human AKAP79-anchored PKC selectively phosphorylates the Robo3.1 receptor subtype on serine 1330
We report the case of a 10-month-old girl with cross-fixation and inability to abduct who was genetically proven to have horizontal gaze palsy with progressive scoliosis (recessive ROBO3 mutations).
Robo3.1A may prevent the Slit responsiveness by recruiting Robo1 (show ROBO1 Antibodies)/2 into a late endosome- and lysosome-dependent degradation pathway.
The novel ROBO3 mutation in this family may be among the most deleterious
This patient had clinical and neuroimaging characteristics considered pathognomonic of horizontal gaze palsy and progressive scoliosis and yet did not have ROBO3 mutations
Three novel ROBO3 mutations have been identified in consanguineous patients with horizontal gaze palsy and progressive scoliosis.
RIG-I (show DDX58 Antibodies) or melanoma differentiation-associated gene (MDA)5 (show IFIH1 Antibodies) signaling through mitochondrial antiviral signaling protein MAVS (show MAVS Antibodies) is required for activation of interferon (show IFNA Antibodies) (IFN)-beta (show IFNB1 Antibodies) production by rotavirus-infected intestinal epithelial cells.
Slit3 (show SLIT1 Antibodies) inhibits Robo3-induced invasion of synovial fibroblasts in rheumatoid arthritis.
mutations in the ROBO3 gene, which shares homology with roundabout (show ROBO1 Antibodies) genes important in axon guidance in developing Drosophila, zebrafish, and mouse.
Data show that Robo and Robo2 promote midline repulsion, while Robo2 and Robo3 specify the position of longitudinal axon pathways.
The transient cell-specific expression of Robo3 plays a crucial role in establishing neural circuits in the Drosophila visual system by selectively regulating pathway choice for posterior-most R8 growth cones.
Robo3 expression is one of a suite of chordotonal neuron properties that depend on expression of the proneural gene atonal.
robo, robo2, and robo3 play a role in the guidance of sensory axons in the Drosophila embryo by both slit-dependent and slit-independent mechanisms.
axon guidance molecules roundabout2 and roundabout3 (robo2/3) are necessary for serotonergic neuron differentiation
Slit acts via Robo2 (show ROBO2 Antibodies) in dendrites as a branching/growth factor but not in guidance, while Robo2 (show ROBO2 Antibodies) and Robo3 function in concert in axons to mediate axonal interactions and respond to Slits as guidance factors
This study show that this commissural neuron population includes spinal inhibitory neurons and sensory nociceptors and show that this population depends on Robo/Slit signaling yet crosses the dorsal midline in a Robo3-independent manner.
These findings identify NELL2 (show NELL2 Antibodies) as an axon guidance cue and establish Robo3 as a multifunctional regulator of pathfinding that simultaneously mediates NELL2 (show NELL2 Antibodies) repulsion, inhibits Slit repulsion, and facilitates Netrin attraction to achieve a common guidance purpose.
results suggest that Robo3 evolution was key to sculpting the mammalian brain by converting a receptor for Slit repulsion into one that both silences Slit repulsion and potentiates Netrin attraction
this study demonistrated that Robo3-driven axon midline crossing conditions functional maturation of a large commissural synapse.
Rerouting climbing fibers to an ipsilateral projection reversed complex-spike modulation. Ptf1a (show PTF1A Antibodies)::cre;Robo3(lox/lox (show LOX Antibodies)) mice showed severe ataxia indicating the impact of climbing fi ber input on reciprocity of Purkinje cell fi ring during motor coordination.
Posttranscriptional regulation of Robo3 mediated by Musashi-1 (show MSI1 Antibodies) controls midline crossing of precerebellar neurons.
Pax-2 (show PAX2 Antibodies)/RB binding reverses repression of Rig-1 protein.
The Slit receptors Robo2 (show ROBO2 Antibodies) and Robo3/Rig-1 are expressed in the subventricular zone and the rostral migratory stream and Slit1 (show SLIT1 Antibodies) and Slit2 (show SLIT2 Antibodies) are present in the adult septum and are responsible for both the septum and the CP repulsive activity in vitro
Expression of Rig-1 protein by commissural axons is inversely correlated with Slit sensitivity. Removal of Rig-1 results in a total failure of commissural axons to cross.
two functionally antagonistic isoforms of Robo3 with distinct carboxy termini arising from alternative splicing have been found
In the absence of Sim1a and Arnt2 (show ARNT2 Antibodies), expression of robo3 splice isoform robo3a.1 is increased in the hypothalamus, indicating negative control of robo3a.1 transcription by these factors.
Slit-Robo signaling downregulates N-cadherin (show CDH2 Antibodies) activity to allow apical retraction in newly generated retinal ganglion cells.
These results demonstrate a key role for Robo-Slit signaling in vertebrate longitudinal axon guidance; Robo1 (show ROBO1 Antibodies) and Robo3 restricted the extent of defasciculation of the tract of the postoptic commissure.
The Mauthner neurons are essential for the startle response, and in twitch twice/robo3 mutants misguidance of the Mauthner axons results in a unidirectional startle response.
This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS)\; an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated.
retinoblastoma inhibiting gene 1
, roundabout homolog 3
, roundabout-like protein 3
, roundabout, axon guidance receptor, homolog 3
, roundabout, axon guidance receptor, homolog 3 (Drosophila)
, roundabout 3
, roundabout homolog 3-like
, retinoblastoma-inhibiting gene 1 protein
, roundabout (axon guidance receptor, Drosophila) homolog 3
, twitch twice