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SARDH encodes an enzyme localized to the mitochondrial matrix which catalyzes the oxidative demethylation of sarcosine. Additionally we are shipping Sarcosine Dehydrogenase Antibodies (13) and Sarcosine Dehydrogenase Kits (9) and many more products for this protein.
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Data first reported a deleterious c.551C>T mutation in SARDH in sporadic colorectal cancer (sCRC). SARDH was identified as a novel tumor suppressor gene and was abnormally decreased in sCRC at both the transcriptional and the translational level. SARDH overexpression inhibited the proliferation, migration, and invasion of CRC cell lines, whereas its depletion improved these processes.
The SNPs rs2797840 and rs2073817 in SARDH may serve as an indicator for the occurrence of neural tube defects in the Chinese Han population, and rs2797840 may also be an indicator for folate content of brain.
Expression of sarcosine metabolism-related proteins differed between ILC [invasive lobular carcinoma] and IDC [invasive ductal carcinoma].
SARDH and TMEFF2 cooperate to modulate one-carbon metabolism and invasion of prostate cancer cells.
Mutations in the SARDH gene are associated with sarcosinemia.
This gene encodes an enzyme localized to the mitochondrial matrix which catalyzes the oxidative demethylation of sarcosine. This enzyme is distinct from another mitochondrial matrix enzyme, dimethylglycine dehydrogenase, which catalyzes a reaction resulting in the formation of sarcosine. Mutations in this gene are associated with sarcosinemia. Alternatively spliced transcript variants have been described.
dimethylglycine dehydrogenase-like 1
, sarcosine dehydrogenase, mitochondrial
, sarcosine dehydrogenase
, Sarcosine dehydrogenase