anti-Tryptophan Hydroxylase 2 (TPH2) Antibodies

TPH2 encodes a member of the pterin-dependent aromatic acid hydroxylase family. Additionally we are shipping Tryptophan Hydroxylase 2 Kits (27) and Tryptophan Hydroxylase 2 Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TPH2 121278 Q8IWU9
TPH2 317675 Q8CGU9
TPH2 216343 Q8CGV2
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Top anti-Tryptophan Hydroxylase 2 Antibodies at

Showing 10 out of 151 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-TPH2 Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of TPH2 Antibody (Center) (ABIN653124) in 293 cell line lysates (35 µg/lane). TPH2 (arrow) was detected using the purified polyclonal antibody. TPH2 Antibody (Center) (ABIN653124) IHC analysis in formalin fixed and paraffin embedded mouse brain followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
Dog Goat Un-conjugated EIA, IHC (p) AP23653PU-N TPH2 antibody staining of Paraffin Embedded Human Brain Stem at 4 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining. 0.1 mg Log in to see 6 to 8 Days
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (ff), IHC (p), IP, WB Immunoprecipitation: Tryptophan hydroxylase 2 Antibody [ABIN2616435] - Analysis of raphe nuclei isolated from Sprague-Dawley rat brains using TPH2 Polyclonal Antibody. PA1-778 was coupled to magnetic beads and added to raphe nuclei whole cell extracts for 15 minutes at RT. Immunoprecipitated proteins were assessed by Western blotting (WB), using either mouse anti-TPH2 (Ms TPH2, Lane 2) or sheep anti-TPH2 antibodies (Sh TPH2, Lane 3). As a positive control for the Western blot, non-immunoprecipitated brain lysates were probed with the mouse anti-TPH2 antibody (Lane 1). As a specificity control, a blot containing immunoprecipitated proteins was probed with an antibody specific for Tyrosine Hydroxylase (TH, Lane 4). Data courtesy of the Innovators Program. Immunocytochemistry/Immunofluorescence: Tryptophan hydroxylase 2 Antibody [ABIN2616435] - Analysis in mouse brain cells. Image courtesy of product review by Assaf Vestin. 0.1 mL Log in to see 7 to 9 Days
Human Goat Un-conjugated IHC (p), IHC, ELISA Immunohistochemistry-Paraffin: Tryptophan hydroxylase 2 Antibody [ABIN250870] - staining. 0.1 mg Log in to see 7 to 9 Days
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 16 Days
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 16 Days
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days

TPH2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Tryptophan Hydroxylase 2 Antibodies

  1. Human Polyclonal Tryptophan Hydroxylase 2 Primary Antibody for ICC, IF - ABIN261643 : Sullivan, Grayson, Takahashi, Robertson, Maier, Bethea, Smith, Coleman, Grove: Chronic consumption of a high-fat diet during pregnancy causes perturbations in the serotonergic system and increased anxiety-like behavior in nonhuman primate offspring. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 (PubMed)
    Show all 16 Pubmed References

  2. Mouse (Murine) Polyclonal Tryptophan Hydroxylase 2 Primary Antibody for ELISA - ABIN768606 : Rahim, Meedeniya, Crane: Central serotonergic neuron deficiency in a mouse model of Zellweger syndrome. in Neuroscience 2014 (PubMed)

  3. Human Polyclonal Tryptophan Hydroxylase 2 Primary Antibody for IHC (p), IHC - ABIN250870 : Zhou, Roy, Lipsky, Kuchipudi, Zhu, Taubman, Enoch, Virkkunen, Goldman: Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-hydroxyindoleacetic acid in 4 populations. in Archives of general psychiatry 2005 (PubMed)

  4. Rat (Rattus) Polyclonal Tryptophan Hydroxylase 2 Primary Antibody for WB - ABIN361498 : Matsuo, Izumi, Wakita, Kume, Takada-Takatori, Sawada, Akaike: Haloperidol, spiperone, pimozide and aripiprazole reduce intracellular dopamine content in PC12 cells and rat mesencephalic cultures: implication of inhibition of vesicular transport. in European journal of pharmacology 2010 (PubMed)

  5. Cow (Bovine) Polyclonal Tryptophan Hydroxylase 2 Primary Antibody for WB - ABIN2778285 : Walther, Peter, Bashammakh, Hörtnagl, Voits, Fink, Bader: Synthesis of serotonin by a second tryptophan hydroxylase isoform. in Science (New York, N.Y.) 2003 (PubMed)

  6. Cow (Bovine) Polyclonal Tryptophan Hydroxylase 2 Primary Antibody for WB - ABIN2778284 : Tzvetkov, Brockmöller, Roots, Kirchheiner: Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment. in Pharmacogenetics and genomics 2008 (PubMed)

  7. Cow (Bovine) Polyclonal Tryptophan Hydroxylase 2 Primary Antibody for WB - ABIN2476984 : McKinney, Knappskog, Haavik: Different properties of the central and peripheral forms of human tryptophan hydroxylase. in Journal of neurochemistry 2005 (PubMed)

More Antibodies against Tryptophan Hydroxylase 2 Interaction Partners

Human Tryptophan Hydroxylase 2 (TPH2) interaction partners

  1. This study firstly demonstrated evidence for an association between aberrant cortical folding in the PFC (show CFP Antibodies) and ACC (show ACACA Antibodies) and TPH2 (show TDO2 Antibodies) polymorphism gene related to the pathophysiology of major depressive disorder.

  2. social anxiety disorder entails an overactive presynaptic serotonergic system that, in turn, seems functionally influenced by the TPH2 (show TDO2 Antibodies) G-703T polymorphism in emotionally relevant brain regions

  3. Tryptophan hydroxylase (show TPH1 Antibodies) synthesizes Serotonin and is over-expressed in Suicides.TPH2 mRNA was greater in Suicide Nonsmokers than Suicide Smokers.The absence of altered TPH2 (show TDO2 Antibodies) expression in non-suicide smokers suggests no pharmacological effect of Smoking.

  4. This study shown the significant results were found with TPH2 (show TDO2 Antibodies) rs4570625 involved with fast visual processing as assessed by metacontrast.

  5. Genetic variation in TPH2 (show TDO2 Antibodies) is associated with antidepressant response and may also interact with childhood trauma to influence outcome of antidepressant treatment.

  6. 2-way interaction between TPH2 (show TDO2 Antibodies) rs4290270 and general traumas revealed that TT homozygotes with history of general traumas had an increased risk for suicide attempt. 3-way interaction of general traumas, TPH2 (show TDO2 Antibodies) rs4290270 and ADARB1 (show ADARB1 Antibodies) rs4819035 indicated that highest predisposition to suicide attempt was observed in individuals who experienced general traumas and were TT homozygote for rs4290270 and TT homozygote for rs4819035.

  7. The catalytic domain of TPH1 (show TPH1 Antibodies) shares a sequence identity of 81% with TPH2 (show TDO2 Antibodies). Despite the high sequence identity, differences in the kinetic parameters of the isoforms have been identified; i.e., only TPH1 (show TPH1 Antibodies) displays substrate tryptophan inhibition.

  8. results confirm the role of TPH1 (show TPH1 Antibodies), TPH2 (show TDO2 Antibodies), 5HT2A, CRHR1 (show CRHR1 Antibodies) and ACP1 (show ACP1 Antibodies) variants in the risk of suicidal behavior.

  9. There was no association between rs11179000, rs136494 and rs4570625 polymorphisms of the tryptophan hydroxylase 2 gene and major depressive disorder in a sample of the Colombian population

  10. This study demonstrates that both TPH1 (show TPH1 Antibodies) and TPH2 (show TDO2 Antibodies) are expressed in human and mouse placenta throughout pregnancy and helps to better understand the placental serotonin system, which is crucial for healthy pregnancy and fetal development.

Rhesus Monkey Tryptophan Hydroxylase 2 (TPH2) interaction partners

  1. TPH2 5'- and 3'-regulatory polymorphisms are differentially associated with hypothalamo-pituitary-adrenal axis function and self-injurious behavior in rhesus monkeys

  2. The present study supports the hypothesis that rearing experience and rhTPH2 A2051C interact to influence central 5-HT (show DDC Antibodies) metabolism, HPA (show HPSE Antibodies) axis function, and aggressive behaviors

  3. Study identified 17 single nucleotide polymorphisms; 3'-UTR (show UTS2R Antibodies) polymorphisms were significantly associated with HPA (show HPSE Antibodies) axis activity, especially 2051A>C, which was strikingly correlated with plasma cortisol level in the morning only.

  4. functional significance of two nonsynonymous single nucleotide polymorphisms (SNPs) (C74A and G223A) in rhesus monkey TPH2

Chimpanzee Tryptophan Hydroxylase 2 (TPH2) interaction partners

  1. Association of TPH2 SNP with neuroticism in captive and wild-born chimpanzees living in Japan and Guinea, respectively, was tested.

Zebrafish Tryptophan Hydroxylase 2 (TPH2) interaction partners

  1. these results suggest that fish prefer swimming in conditions that elicits lower activity in tph2 serotonergic neurons in the rostral raphe.

  2. tphR is expressed in serotonergic raphe neurons, similar to tph (show TPH1 Antibodies) genes in mammalian species; tphR is also expressed in the pineal organ where it is likely to be involved in the pathway leading to synthesis of melatonin

Mouse (Murine) Tryptophan Hydroxylase 2 (TPH2) interaction partners

  1. This study demonstrated that tryptophan hydroxylase 2 Deficiency Causes Hyperactivity, Circadian Disruption, and Elimination of Siestas.

  2. No substantial differences in any parameter reflecting their firing activity both in vivo and in vitro were found in raphe nucleus 5-HT (show DDC Antibodies) neurons of Tph2-/-, Tph2+/-, and Tph2+/+ mice

  3. the C1473G polymorphism in the Tph-2 gene considerably influenced the changes in the expression patterns of genes involved in the regulation of neurogenesis and neural apoptosis induced by chronic ethanol treatment.

  4. The results of this study suggests that Tph2(-/-) mice is a useful preclinical model to assess the role of 5-HT (show DDC Antibodies)-dependent mechanisms in psychostimulants action.

  5. both Tph2(-/-) male and female mice were resilient to chronic mild stress-induced hyperlocomotion

  6. 1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin (show LEP Antibodies) genes: implication for behavioral influences of vitamin D.

  7. Litters born to and reared by TPH2-/- mothers showed decreased survival, lower weaning weights and increased cannibalization.

  8. Decreased TPH2 activity cannot be considered a reliable predisposition factor for impaired emotional behavior: in conditions of reduced serotonin production a lowered serotonin degradation rate contributes to the maintenance of brain serotonin

  9. This study showed that optogenetic activation of tryptophan hydroxylase 2-expressing serotonergic neurons in rostral ventromedial medulla in vivo induces a long-lasting pain sensitization measured as mechanical allodynia and thermal hyperalgesia. I

  10. While total cell density in the anterior basolateral amygdala did not differ between genotypes, the number and density of the GABAergic interneurons were significantly decreased in Tph2(-/-) mice.

Tryptophan Hydroxylase 2 (TPH2) Antigen Profile

Protein Summary

This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.

Gene names and symbols associated with TPH2

  • tryptophan hydroxylase 2 (TPH2) antibody
  • tryptophan hydroxylase 2 (Tph2) antibody
  • tryptophan hydroxylase 2 (tph2) antibody
  • tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) (tph2) antibody
  • ADHD7 antibody
  • AU043594 antibody
  • Ntph antibody
  • tphR antibody
  • wu:fq15a04 antibody

Protein level used designations for TPH2

neuronal tryptophan hydroxylase , tryptophan 5-hydroxylase 2 , tryptophan 5-monooxygenase 2 , tryptophan hydroxylase-2 , tryptophan hydroxylase 2 , tryptophan 5-hydroxylase 2-like , tph2a , tryptophan hydroxylase R

121278 Homo sapiens
664730 Macaca mulatta
317675 Rattus norvegicus
408026 Gallus gallus
467070 Pan troglodytes
481165 Canis lupus familiaris
100009684 Equus caballus
100303678 Meleagris gallopavo
100459809 Pongo abelii
100486097 Xenopus (Silurana) tropicalis
100588345 Nomascus leucogenys
407712 Danio rerio
216343 Mus musculus
100627725 Sus scrofa
100336620 Bos taurus
100724594 Cavia porcellus
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