anti-UPF2 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF2) Antibodies

UPF2 encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance.

list all antibodies Gene Name GeneID UniProt
Anti-Human UPF2 UPF2 26019 Q9HAU5
Anti-Mouse UPF2 UPF2 326622  
Anti-Rat UPF2 UPF2 361271  
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Top anti-UPF2 Regulator of Nonsense Transcripts Homolog (Yeast) Antibodies at antibodies-online.com

Showing 10 out of 49 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-UPF2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, WB UPF2 Antibody (Center)  western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the UPF2  antibody detected the UPF2  protein (arrow). UPF2 Antibody (Center)  flow cytometric analysis of MCF-7 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, FACS, WB UPF2 Antibody (Center) flow cytometric analysis of MCF-7 cells (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. UPF2 Antibody (Center) western blot analysis in MCF-7 cell line lysates (35 µg/lane). This demonstrates the UPF2 antibody detected the UPF2 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ICC, IF, WB   0.1 mL Log in to see 8 to 11 Days
$514.63
Details
Horse Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various cell lines, using UPF2 antibody. Immunohistochemistry of paraffin-embedded rat kidney using UPF2 antibody at dilution of 1:200 (40x lens). 100 μL Log in to see 16 Days
$334.02
Details
Human Rabbit Un-conjugated FACS, WB Western blot analysis in MCF-7 cell line lysates (35ug/lane). Flow cytometric analysis of MCF-7 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 2 to 3 Days
$515.63
Details
Bat Goat Un-conjugated ELISA   100 μg Log in to see 7 to 9 Days
$507.83
Details
Human Rabbit Un-conjugated WB Western Blot: UPF2 Antibody [NBP1-80460] - HepG2 cell lysate, concentration 0.2-1 ug/ml. 100 μL Log in to see 8 to 11 Days
$485.88
Details
Human Goat PE ELISA   100 μL Log in to see 16 Days
$653.71
Details

Top referenced anti-UPF2 Regulator of Nonsense Transcripts Homolog (Yeast) Antibodies

  1. Human Polyclonal UPF2 Primary Antibody for ICC, IF - ABIN4364426 : Nickless, Jackson, Marasa, Nugent, Mercer, Piwnica-Worms, You: Intracellular calcium regulates nonsense-mediated mRNA decay. in Nature medicine 2014 (PubMed)

More Antibodies against UPF2 Regulator of Nonsense Transcripts Homolog (Yeast) Interaction Partners

Human UPF2 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF2) interaction partners

  1. we find that the interaction of UPF2 with UPF3b interferes with the assembly of the UPF2-eRF3 complex, and that UPF2 binds UPF3b more strongly than eRF3

  2. UPF2 binds the FRB domain of SMG1 (show SMG1 Antibodies), a region that regulates the related mTOR (show FRAP1 Antibodies) kinase.

  3. This study demonstrated the quantitative regulation of Upf1 (show UPF1 Antibodies) and Upf2 proteins by ubiquitin-proteasome system and SMG1 (show SMG1 Antibodies).

  4. UPF2 MIF4G-1 and MIF4G-2 domains appear to have a crucial scaffolding role, while the MIF4G-3 domain is the key module required for triggering nonsense-mediated decay.

  5. Data show that upon binding to Upf2, the regulatory CH domain of Upf1 (show UPF1 Antibodies) undergoes a large conformational change, causing the catalytic helicase domain to bind RNA less extensively and triggering its helicase activity.

  6. The authors propose that the bipartite mode of UPF2 binding to UPF1 (show UPF1 Antibodies) brings the ribosome and the exon junction complex in close proximity by forming a tight complex after an initial weak encounter with either element.

  7. The complex between the interacting domains of human UPF2 and UPF3b (show UPF3B Antibodies) at a 1.95 A resolution.

  8. During nonsense-mediated mRNA decay, CBP80 (show NCBP1 Antibodies) interacts with Upf1 (show UPF1 Antibodies) and promotes the interaction of Upf1 (show UPF1 Antibodies) with Upf2 but not with Stau1 (show STAU1 Antibodies).

  9. UPF2-silenced HeLa cells were impaired in their ability to recognize ectopically expressed aberrant premature termination codon transcripts

  10. UPF2 and UPF3b (show UPF3B Antibodies) cooperatively stimulate both ATPase (show DNAH8 Antibodies) and RNA helicase (show DDX46 Antibodies) activities of UPF1 (show UPF1 Antibodies).

Mouse (Murine) UPF2 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF2) interaction partners

  1. Upon removal of TDRD6, the association of several mRNAs with UPF1 and UPF2 is disturbed, and the long 3' UTR-stimulated but not the downstream exon-exon junction triggered pathway of NMD is impaired.This function depends on TDRD6-promoted assembly of mRNA and decay enzymes in Chromatoid bodies .

  2. we report that UPF2-mediated nonsense-mediated mRNA decay (NMD) plays an essential role in male germ cells by eliminating ubiquitous genes-derived, longer 3'UTR (show UTS2R Antibodies) transcripts, and that this role is independent of its canonical role in degrading "premature termination codon" (PTC (show PTCH1 Antibodies))-containing transcripts in somatic cell lineages

  3. UPF2, a nonsense-mediated mRNA decay factor, is required for prepubertal Sertoli cell development and male fertility by ensuring fidelity of the transcriptome.

  4. Study find that loss of Upf2 during fetal liver development is incompatible with postnatal life due to failure of terminal differentiation. Moreover, deletion of Upf2 in the adult liver results in hepatosteatosis and disruption of liver homeostasis.

  5. Hematopoietic-specific deletion of Upf2, a core NMD factor, led to the rapid, complete, and lasting cell-autonomous extinction of all hematopoietic stem and progenitor populations.

UPF2 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF2) Antigen Profile

Protein Summary

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene\\\\; both variants encode the same protein.

Gene names and symbols associated with UPF2

  • UPF2, regulator of nonsense mediated mRNA decay (UPF2) antibody
  • UPF2 regulator of nonsense transcripts homolog (yeast) (Upf2) antibody
  • UPF2, regulator of nonsense mediated mRNA decay (Upf2) antibody
  • UPF2 regulator of nonsense transcripts homolog (yeast) (UPF2) antibody
  • UPF2 regulator of nonsense transcripts homolog (yeast) (upf2) antibody
  • HUPF2 antibody
  • RENT2 antibody
  • smg-3 antibody

Protein level used designations for UPF2

nonsense mRNA reducing factor 2 , regulator of nonsense transcripts 2 , smg-3 homolog, nonsense mediated mRNA decay factor , up-frameshift suppressor 2 homolog , yeast Upf2p homolog , UPF2 regulator of nonsense transcripts homolog (yeast)

GENE ID SPECIES
26019 Homo sapiens
326622 Mus musculus
361271 Rattus norvegicus
419100 Gallus gallus
450304 Pan troglodytes
487130 Canis lupus familiaris
569006 Danio rerio
781181 Bos taurus
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