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UPF2 encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance.
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Human Polyclonal UPF2 Primary Antibody for ICC, IF - ABIN4364426
Nickless, Jackson, Marasa, Nugent, Mercer, Piwnica-Worms, You: Intracellular calcium regulates nonsense-mediated mRNA decay. in Nature medicine 2014
we find that the interaction of UPF2 with UPF3b interferes with the assembly of the UPF2-eRF3 complex, and that UPF2 binds UPF3b more strongly than eRF3
UPF2 binds the FRB domain of SMG1 (show SMG1 Antibodies), a region that regulates the related mTOR (show FRAP1 Antibodies) kinase.
This study demonstrated the quantitative regulation of Upf1 (show UPF1 Antibodies) and Upf2 proteins by ubiquitin-proteasome system and SMG1 (show SMG1 Antibodies).
UPF2 MIF4G-1 and MIF4G-2 domains appear to have a crucial scaffolding role, while the MIF4G-3 domain is the key module required for triggering nonsense-mediated decay.
Data show that upon binding to Upf2, the regulatory CH domain of Upf1 (show UPF1 Antibodies) undergoes a large conformational change, causing the catalytic helicase domain to bind RNA less extensively and triggering its helicase activity.
The authors propose that the bipartite mode of UPF2 binding to UPF1 (show UPF1 Antibodies) brings the ribosome and the exon junction complex in close proximity by forming a tight complex after an initial weak encounter with either element.
The complex between the interacting domains of human UPF2 and UPF3b (show UPF3B Antibodies) at a 1.95 A resolution.
During nonsense-mediated mRNA decay, CBP80 (show NCBP1 Antibodies) interacts with Upf1 (show UPF1 Antibodies) and promotes the interaction of Upf1 (show UPF1 Antibodies) with Upf2 but not with Stau1 (show STAU1 Antibodies).
UPF2-silenced HeLa cells were impaired in their ability to recognize ectopically expressed aberrant premature termination codon transcripts
UPF2 and UPF3b (show UPF3B Antibodies) cooperatively stimulate both ATPase (show DNAH8 Antibodies) and RNA helicase (show DDX46 Antibodies) activities of UPF1 (show UPF1 Antibodies).
Upon removal of TDRD6, the association of several mRNAs with UPF1 and UPF2 is disturbed, and the long 3' UTR-stimulated but not the downstream exon-exon junction triggered pathway of NMD is impaired.This function depends on TDRD6-promoted assembly of mRNA and decay enzymes in Chromatoid bodies .
we report that UPF2-mediated nonsense-mediated mRNA decay (NMD) plays an essential role in male germ cells by eliminating ubiquitous genes-derived, longer 3'UTR (show UTS2R Antibodies) transcripts, and that this role is independent of its canonical role in degrading "premature termination codon" (PTC (show PTCH1 Antibodies))-containing transcripts in somatic cell lineages
UPF2, a nonsense-mediated mRNA decay factor, is required for prepubertal Sertoli cell development and male fertility by ensuring fidelity of the transcriptome.
Study find that loss of Upf2 during fetal liver development is incompatible with postnatal life due to failure of terminal differentiation. Moreover, deletion of Upf2 in the adult liver results in hepatosteatosis and disruption of liver homeostasis.
Hematopoietic-specific deletion of Upf2, a core NMD factor, led to the rapid, complete, and lasting cell-autonomous extinction of all hematopoietic stem and progenitor populations.
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene\\\\; both variants encode the same protein.
nonsense mRNA reducing factor 2
, regulator of nonsense transcripts 2
, smg-3 homolog, nonsense mediated mRNA decay factor
, up-frameshift suppressor 2 homolog
, yeast Upf2p homolog
, UPF2 regulator of nonsense transcripts homolog (yeast)