V-Set Domain Containing T Cell Activation Inhibitor 1 Proteins (VTCN1)

VTCN1 encodes a protein belonging to the B7 costimulatory protein family. Additionally we are shipping VTCN1 Antibodies (232) and VTCN1 Kits (29) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
VTCN1 242122 Q7TSP5
VTCN1 79679 Q7Z7D3
VTCN1 295322 Q501W4
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Top VTCN1 Proteins at antibodies-online.com

Showing 10 out of 38 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$6,041.49
Details
HEK-293 Cells Human AVI tag,Biotin,His tag Biotinylated Human B7-H4 (recommended for biopanning) on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%. Measured by its binding ability in a functional ELISA. Immobilized Anti-B7-H4 mAb,Human IgG1 at 2μg/mL (100 μL/well) can bind Biotinylated Human B7-H4, His Tag  with a linear range of 3-48 ng/mL. 200 μg Log in to see 5 Days
$1,518.00
Details
HEK-293 Cells Human His tag Human B7-H4, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. Immobilized Human B7-H4, His Tag  with a linear range of 0.4-6 ng/mL. 100 μg Log in to see 2 to 3 Days
$275.00
Details
Human Cells Mouse Fc Tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
Human Cells Human His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
Human Cells Rat His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
HEK-293 Cells Human His tag 50 μg Log in to see 2 to 3 Days
$595.00
Details
HEK-293 Cells Mouse His tag   100 μg Log in to see 2 to 3 Days
$550.00
Details
Escherichia coli (E. coli) Human GST tag V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) (AA 26-258), (partial) protein (GST tag) 50 μg Log in to see 13 to 16 Days
$242.00
Details

VTCN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , , ,
,
Human , , , ,
, , , , , ,
Rat (Rattus) , ,

More Proteins for V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) Interaction Partners

Mouse (Murine) V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) interaction partners

  1. this study shows that B7-H4 knockout hosts mount greater tumor-associated anti-tumor T cell responses and display reduced tumors

  2. Results highlight an importance of VTCN1 stabilization on cell surfaces for the restoration of altered balance of immune control during T1D.

  3. Ablation of B7-H3 (show CD276 Proteins) but Not B7-H4 Results in Highly Increased Tumor Burden in a Murine Model of Spontaneous Prostate Cancer

  4. B7-H4 expression by nonhematopoietic cells in the tumor microenvironment promotes antitumor immunity.

  5. that B7x can modulate kidney damage in autoimmune diseases including lupus nephritis and anti-glomerular basement membrane disease

  6. B7-H4 can inhibit both antitumor T cells and protumor myeloid-derived suppressor cells (

  7. The endogenous expression of B7-H4 in donor beta cells from transgenic mice prolongs islet allograft survival, confirming the negative role of B7-H4 in regulating alloreactive T-cell responses.

  8. Local overexpression of B7x on pancreatic beta cells is sufficient to abolish CD8 (show CD8A Proteins) T cell-induced diabetes.

  9. B7-H4 expression may influence the outcome of T-cell tumor cell interactions. Tumor-associated macrophage induced membrane-bound B7-H4 on lung cancer cell represents a novel mechanism by which lung cancer cells evade immune recognition and destruction.

  10. Overexpression of B7-H4 was shown in tumor infiltrated dendritic cells.

Human V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1) interaction partners

  1. our study demonstrates a strong promoting role of B7-H4 in lung tumor growth, progression and metastasis

  2. results demonstrated for the first time that miR (show MLXIP Proteins)-125b-5p could regulate the inflammatory state of macrophages via directly targeting B7-H4

  3. B7-H4 is highly expressed in pancreatic cancer, and is an independent predictor of poor prognosis.

  4. Evidence of associations between genotypes and Juvenile Idiopathic Arthritis were found for VTCN1, while VTCN1_rs2358820 GA was associated with Uveitis .

  5. B7-H4 is highly expressed in human OSCC tissue, and the B7-H4 expression level was associated with the clinicopathological parameters containing pathological grade and lymph node status.

  6. High B7-H4 expression is associated with non-Hodgkin lymphoma.

  7. B7-H4 is frequently expressed in ovarian serous carcinomas, especially high-grade serous carcinomas, and may represent a novel immunotherapeutic target in this cancer.

  8. While PD-L1 (show CD274 Proteins) expression correlated with MSI (show MSI1 Proteins) and high grade endometrial tumors, B7-H4 expression was independent of grade, histology and immune cell infiltration.

  9. the present review highlights the therapeutic potential of targeting B7-H4 in cancer

  10. Survival rate of the patients with higher B7-H4 expression was significantly worse than that of the patients with lower B7-H4 expression.

VTCN1 Protein Profile

Protein Summary

This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with VTCN1

  • V set domain containing T cell activation inhibitor 1 L homeolog (vtcn1.L)
  • V-set domain containing T cell activation inhibitor 1 (VTCN1)
  • V-set domain containing T-cell activation inhibitor 1 (VTCN1)
  • V set domain containing T cell activation inhibitor 1 (vtcn1)
  • V-set domain containing T cell activation inhibitor 1 (Vtcn1)
  • B7-H4 protein
  • B7h.5 protein
  • B7H4 protein
  • B7S1 protein
  • B7X protein
  • BC032925 protein
  • PRO1291 protein
  • RGD1311204 protein
  • VCTN1 protein

Protein level used designations for VTCN1

V-set domain-containing T-cell activation inhibitor 1 , V-set domain containing T cell activation inhibitor 1 , V-set domain containing T-cell activation inhibitor 1 , immune costimulatory protein B7-H4 , t cell costimulatory molecule B7x , B7 family member, H4 , B7 superfamily member 1 , T cell costimulatory molecule B7x , T-cell costimulatory molecule B7x

GENE ID SPECIES
379070 Xenopus laevis
418323 Gallus gallus
469433 Pan troglodytes
493551 Xenopus (Silurana) tropicalis
242122 Mus musculus
79679 Homo sapiens
295322 Rattus norvegicus
Selected quality suppliers for VTCN1 Proteins (VTCN1)
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