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anti-Human DMBT1 Antibodies:
anti-Mouse (Murine) DMBT1 Antibodies:
anti-Rat (Rattus) DMBT1 Antibodies:
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Present study indicated that DMBT1 is upregulated in stools of colorectal cancer (CRC (show CALR Antibodies)) patients, while exhibiting variable expression in CRC (show CALR Antibodies) tissues. Loss of DMBT1 protein in CRC (show CALR Antibodies) tissues is significantly associated with adverse clinicopathological features (advanced stage, lymph node or distant metastasis and high histological grade).
We investigated whether PRH1 (show PRH1 Antibodies) and PRH2 (show PROC Antibodies) polymorphisms in saliva (show RAG1AP1 Antibodies) acidic proline-rich protein (PRP (show C4BPA Antibodies)) receptors for indigenous bacteria match and predict individual differences in the development of caries..They instead developed 3.9-fold more caries than P1 children from plaque accumulation in general when treated with orthodontic multibrackets; and had basic PRP (show C4BPA Antibodies) polymorphisms and low DMBT1-mediated S. mutans adhesion
We found that in 3 different populations, mucosal DMBT1 expression was significantly increased (2.5 fold) in individuals with dysplasia compared to multifocal atrophic gastritis without intestinal metaplasia; the increase was also observed in individuals with advanced gastritis and positive H. pylori infection.
DMBT1 is expressed differently in cholangiocarcinogenesis and poorer patients' survival rates are associated with absent DMBT1 expression in non-neoplastic biliary tissue, suggesting a tumour-suppressive role of DMBT1 in early cholangiocarcinogenesis
we conclude that DMBT1 by binding with CRNDE and c-IAP1 (show BIRC2 Antibodies) associated with PI3K (show PIK3CA Antibodies)-AKT (show AKT1 Antibodies) pathway is crucial for GBC carcinogenesis, and targeting this pathway may be pivotal in the treatment of GBC.
Studies indicate that salivary scavenger and agglutinin (SALSA) binds to many microbes and endogenous complement components.
The data suggest that DMBT1 inhibition of twitching motility contributes to the mechanisms by which mucosal fluids protect against P. aeruginosa infection.
this study shows that SAG inhibits the Interaction of DC-SIGN (show CD209 Antibodies) and Langerin (show CD207 Antibodies) with oral microorganisms
These results support the hypothesis that genetic variation in DMBT1 may influence microbial defense.
DMBT1 DNA copy number variation does not affect susceptibility to Crohn's disease in Northern Europeans.
a novel role for interleukin-27 (IL-27 (show IL27 Antibodies)) as mediator of intestinal epithelial barrier protection mediated via DMBT1 and IDO1 (show IDO1 Antibodies)
DMBT1 functions as an important endothelium-derived ECM (show MMRN1 Antibodies) protein that is able to bind angiogenic factors and promote adhesion, migration, proliferation, and angiogenesis as well as vascular repair.
Data show that deletion of hensin from intercalated cells results in the absence of typical alpha-intercalated cells and the consequent development of complete distal renal tubular acidosis (dRTA).
Carboxyl-terminal Asp (show C3 Antibodies)(D) -3, Thr (show TRH Antibodies)(T) -2, Lys (show LYZ Antibodies)(K) -1 and Leu(L) 0 are involved in numerous interactions with PDZ1 domains of NHERF/EBP50 (show SLC9A3R1 Antibodies) and PDZK1/CAP70 (show PDZK1 Antibodies).
binds gram-positive and gram-negative bacteria and interacts with lung surfactant protein D (show SFTPD Antibodies)
Muclin is a Golgi cargo receptor that binds to regulated secretory proteins under the mildly acidic pH conditions that exist in the trans-Golgi network
Mouse embryonic stem cells seeded on hensin formed hemispheric epithelial structures whose outermost layer terminally differentiated to an epithelium that resembled the visceral endoderm.
The results identify a novel mammary tumor susceptibility locus in mice and support a role for DMBT1 in suppression of mammary tumors in both mice and women.
Dmbt1(-/-) mice display enhanced susceptibility to dextran sulfate sodium-induced colitis and elevated Tnf (show TNF Antibodies), Il6 (show IL6 Antibodies), and Nod2 (show NOD2 Antibodies) expression levels during inflammation.
Demonstrate that galectin-3 (show LGALS3 Antibodies) plays a critical role in hensin ECM (show MMRN1 Antibodies) assembly by oligomerizing secreted monomeric hensin.
Data suggest that DMBT1 is secreted by oviduct epithelium and plays role in sperm-ovum interactions during in vitro fertilization.
Involvement of AKAP4 (show AKAP4 Antibodies) in the formation of the fibrous sheath on boar precursor sperm cells and the phosphorylation of pro-AKAP4 (show AKAP4 Antibodies) as an early step in the signal transduction pathway gated by DMBT1 that leads to sperm selection through acrosome alteration.
Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor supressor gene, but rather play a role in the interaction of tumor cells and the immune system.
, deleted in malignant brain tumors 1 protein
, glycoprotein 340
, salivary agglutinin
, surfactant pulmonary-associated D-binding protein
, deleted in malignant brain tumors 1 pseudogene
, glycoprotein 300
, mucin-like glycoprotein
, deleted in malignant brain tumors 1
, hypothetical protein