CD46 antibody
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- Target See all CD46 Antibodies
- CD46
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This CD46 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunoprecipitation (IP), Functional Studies (Func), Enzyme Immunoassay (EIA)
- Specificity
- The monoclonal antibody M177 recognizes CD46, also designated membrane cofactor protein (MCP).
- Cross-Reactivity (Details)
- Species reactivity (tested):Human
- Purification
- Protein G
- Immunogen
- Purified MCP
- Clone
- M177
- Isotype
- IgG1
- Top Product
- Discover our top product CD46 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.1 mg/mL
- Buffer
- PBS, 0.1 % bovine serum albumin
- Storage
- 4 °C
- Storage Comment
- Store at 2 - 8 °C.
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- Target
- CD46
- Alternative Name
- CD46 / MCP (CD46 Products)
- Synonyms
- AHUS2 antibody, MCP antibody, MIC10 antibody, TLX antibody, TRA2.10 antibody, Mcp antibody, CD46 antibody, CD46 molecule antibody, CD46 antigen, complement regulatory protein antibody, CD46 molecule, complement regulatory protein antibody, membrane cofactor protein-like antibody, CD46 antibody, Cd46 antibody, LOC100341359 antibody, LOC103789310 antibody
- Background
- CD46 is a 45-70 kDa protein with genetic and tissue-specific heterogeneity. It is expressed on every cell and tissue, with the exception of erythrocytes. CD46 serves to inhibit complement activation on host tissue. It performs this function by serving as a cofactor which binds to C3b and C4b. This binding is permitted by factor I, a serine protease of plasma, to degrade C3b and C4b and serves to protect the host cell against autologous attack. It also serves as a receptor for measles virus. Four isoforms of CD46 predominate and arise by alternative splicing of a single CD46 gene. CD46 cDNA encodes a signal sequence followed by four complement control protein domains (also called short consensus repeats (SCR).Synonyms: MIC10, Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen
- Gene ID
- 4179
- NCBI Accession
- NP_002380
- UniProt
- P15529
- Pathways
- Regulation of Actin Filament Polymerization
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