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CD11b antibody

ITGAM Reactivity: Human FACS, Func Host: Mouse Monoclonal ICRF44 unconjugated
Catalog No. ABIN1176910
  • Target See all CD11b (ITGAM) Antibodies
    CD11b (ITGAM) (Integrin alpha M (ITGAM))
    Reactivity
    • 253
    • 162
    • 60
    • 33
    • 17
    • 17
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    • 11
    • 7
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    • 4
    • 4
    • 2
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    • 1
    Human
    Host
    • 134
    • 104
    • 102
    • 2
    • 1
    • 1
    Mouse
    Clonality
    • 245
    • 96
    • 1
    Monoclonal
    Conjugate
    • 111
    • 37
    • 29
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    • 21
    • 10
    • 7
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    • 5
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    • 3
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    • 3
    • 3
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    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD11b antibody is un-conjugated
    Application
    • 256
    • 84
    • 79
    • 75
    • 54
    • 39
    • 36
    • 22
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    Flow Cytometry (FACS), Functional Studies (Func)
    Brand
    BD Pharmingen™
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Sterility
    0.2 μm filtered
    Endotoxin Level
    Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
    Immunogen
    Human monocytes
    Clone
    ICRF44
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product ITGAM Primary Antibody
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.0 mg/mL
    Buffer
    No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
    Preservative
    Azide free
    Storage
    4 °C
    Storage Comment
    Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
  • Target
    CD11b (ITGAM) (Integrin alpha M (ITGAM))
    Alternative Name
    CD11b/Mac-1 (ITGAM Products)
    Synonyms
    CD11b/CD18 antibody, CR3 antibody, CR3A antibody, Cd11b antibody, F730045J24Rik antibody, Ly-40 antibody, MAC1 antibody, Mac-1 antibody, Mac-1a antibody, CD11B antibody, MAC-1 antibody, MAC1A antibody, MO1A antibody, SLEB6 antibody, C3bi antibody, integrin subunit alpha M antibody, integrin alpha M antibody, integrin, alpha M (complement component 3 receptor 3 subunit) antibody, integrin alpha-M antibody, ITGAM antibody, Itgam antibody, LOC100351865 antibody
    Background
    The ICRF44 monoclonal antibody reacts with CD11b, the 165-kDa adhesion glycoprotein that associates with the 95-kDa integrin beta2 (CD18) to form the CD11b/CD18 complex, also known as Mac-1 or CR3. CD11b is expressed on activated lymphocytes, monocytes, granulocytes, and a subset of NK cells. CD11b functions in cell-cell and cell-substrate interactions and is a receptor for iC3b, CD54 (ICAM-1), CD102 (ICAM-2) and CD50 (ICAM-3). This antibody significantly inhibits polymorphonuclear leukocyte aggregation in response to fMLP.
    Synonyms: Mac-1alpha, integrin alphaM subunit, CR3 alpha chain
    Pathways
    Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation
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