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Paxillin antibody
PXN
Reactivity: Human, Mouse, Rat
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-Paxillin Antibody
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Target
See all Paxillin (PXN) Antibodies
Paxillin (PXN)
Reactivity
All reactivities for Paxillin antibodies
Human, Mouse, Rat
Host
All hosts for Paxillin antibodies
Rabbit
Clonality
All clonalities for Paxillin antibodies
Polyclonal
Conjugate
All conjugates for Paxillin antibodies
This Paxillin antibody is un-conjugated
Application
All applications for Paxillin antibodies
Western Blotting (WB)
Specificity
The antibody recognizes 68 kDa Paxillin.
Purification
Affinity Purified
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Discover our top product PXN Primary Antibody
Alternatives
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Application Details
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Application Notes
Western Blot: 1-2 μg/mL. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
PBS, 0.02 % Sodium Azide, 50 % Glycerol, 1 % BSA
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
-20 °C/-80 °C
Storage Comment
Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.
Target Details for Paxillin
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Target
Paxillin (PXN)
Alternative Name
Paxillin / PXN (PXN Products )
Synonyms
AW108311 antibody, AW123232 antibody, Pax antibody, CG18061 antibody, CG18576 antibody, CG31794 antibody, CT40481 antibody, CT42454 antibody, DPaxillin antibody, DPxn antibody, DPxn37 antibody, Dmel\\CG31794 antibody, Dpax antibody, DpaxA antibody, PDLP antibody, dPax antibody, pax antibody, wu:fw71f12 antibody, PXN antibody, LOC100220858 antibody, paxillin antibody, Paxillin antibody, paxillin S homeolog antibody, paxillin a antibody, PXN antibody, Pxn antibody, Pax antibody, pxn.S antibody, pxna antibody, LOC696336 antibody, pxn antibody
Background
Paxillin is a 64 kDa cytoskeletal adapter protein involved in organisation and function of focal adhesions, which are critical to cell adhesion and migration. This in turn plays a role in a wide variety of processes including embryogenesis, organogenesis, wound repair, inflammation and cancer. Paxillin contains LD motifs, LIM domains, SH3 and SH2 binding domains that serve as docking sites for cytoskeletal proteins, tyrosine kinases (e.g., FAK, Pyk 2, Src), serine/threonine kinases, GTPase activating proteins and other adaptor proteins (e.g., Actin, Vinculin, Crk). Paxillin is phosphorylated by another focal adhesion component, focal adhesion kinase (FAK), at tyrosine 118. Phospho-Tyr118 may provide a docking site for recruitment of other signaling molecules to focal adhesions.Synonyms: FLJ16691
Gene ID
5829
NCBI Accession
NP_001074324
UniProt
P49023
Pathways
MAPK Signaling , EGFR Signaling Pathway , Response to Growth Hormone Stimulus , Cell-Cell Junction Organization , Maintenance of Protein Location , CXCR4-mediated Signaling Events , Signaling Events mediated by VEGFR1 and VEGFR2 , Signaling of Hepatocyte Growth Factor Receptor , VEGF Signaling
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