CD11b antibody (Biotin)
-
- Target See all CD11b (ITGAM) Antibodies
- CD11b (ITGAM) (Integrin alpha M (ITGAM))
-
Reactivity
- Rat
-
Host
- Mouse
-
Clonality
- Monoclonal
-
Conjugate
- This CD11b antibody is conjugated to Biotin
-
Application
- Flow Cytometry (FACS)
- Specificity
- Rat CD11b/c (Macrophages)
- Immunogen
- Rat Peritoneal Macrophages . Fusion Partner: NSO/U mouse myeloma cell line . Immunocyte Donor: BALB/c spleen
- Clone
- OX-42
- Isotype
- IgG2a
- Top Product
- Discover our top product ITGAM Primary Antibody
-
-
- Application Notes
- This clone is reported to work with frozen and paraffin sections (3).
- Restrictions
- For Research Use only
-
- Concentration
- 0.5 µg/10 cells
- Buffer
- Biotin conjugated Ig buffered in PBS, 0.02% NaN and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml. (Purified from ascitic fluid via Protein G Chromatography)
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
-
- Target
- CD11b (ITGAM) (Integrin alpha M (ITGAM))
- Alternative Name
- CD11b/c (ITGAM Products)
- Synonyms
- CD11b/CD18 antibody, CR3 antibody, CR3A antibody, Cd11b antibody, F730045J24Rik antibody, Ly-40 antibody, MAC1 antibody, Mac-1 antibody, Mac-1a antibody, CD11B antibody, MAC-1 antibody, MAC1A antibody, MO1A antibody, SLEB6 antibody, C3bi antibody, integrin subunit alpha M antibody, integrin alpha M antibody, integrin, alpha M (complement component 3 receptor 3 subunit) antibody, integrin alpha-M antibody, ITGAM antibody, Itgam antibody, LOC100351865 antibody
- Background
- Anti-rat CD11b/c monoclonal antibody recognizes most macrophages including resident peritoneal macrophages, kupffer cells, but only approximately 35% of alveolor macrophages (2). ABIN133346also labels dendritic cells extensively, granulocytes and cells with morphology of microglia in the brain. It precipitates three polypeptides of M.W. 160, 103 and 95 kDa. ABIN133346inhibits complement mediated rosettes and is probably the rat equivalent of the human receptor of iC3b called CR3. anti-rat CD11b/c mAb should prove useful in the recognition of macrophages and microglia. This clone is reported to work with frozen and paraffin sections (3).
- Pathways
- Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation
-