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ATM antibody
ATM
Reactivity: Human
WB
Host: Mouse
Monoclonal
4H1
unconjugated
Product Details anti-ATM Antibody
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Target
See all ATM Antibodies
ATM
(Ataxia Telangiectasia Mutated (ATM))
Reactivity
All reactivities for ATM antibodies
Human
Host
All hosts for ATM antibodies
Mouse
Clonality
All clonalities for ATM antibodies
Monoclonal
Conjugate
All conjugates for ATM antibodies
This ATM antibody is un-conjugated
Application
All applications for ATM antibodies
Western Blotting (WB)
Sequence
CP-CFIKKPFDRG EVESMEDDTN GN
Specificity
This antibody reacts with ATM.
Cross-Reactivity (Details)
Species reactivity (tested):Human
Immunogen
Carrier protein (CP) conjugated synthetic peptide
Clone
4H1
Isotype
IgG1
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Discover our top product ATM Primary Antibody
Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
1.0 mg/mL
Buffer
Protein A agarose, PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.
Preservative
Without preservative
Handling Advice
Avoid repeated freezing and thawing.
Storage
-20 °C
Storage Comment
Upon receipt, store (in aliqouts) at -20 °C.
Target Details for ATM
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Target
ATM
(Ataxia Telangiectasia Mutated (ATM))
Alternative Name
ATM (ATM Products )
Synonyms
ATM antibody, Atm antibody, CG6535 antibody, Dmel\\CG6535 antibody, Tefu antibody, atm antibody, atm/tefu antibody, dATM antibody, tef antibody, Xatm antibody, at1 antibody, atdc antibody, tel1 antibody, telo1 antibody, AT1 antibody, ATA antibody, ATC antibody, ATD antibody, ATDC antibody, ATE antibody, TEL1 antibody, TELO1 antibody, AI256621 antibody, C030026E19Rik antibody, telomere fusion antibody, ATM serine/threonine kinase L homeolog antibody, ATM serine/threonine kinase antibody, ataxia telangiectasia mutated antibody, ataxia telangiectasia mutated (atm) antibody, serine/threonine-protein kinase ATM antibody, tefu antibody, atm.L antibody, atm antibody, ATM antibody, EDI_100660 antibody, CpipJ_CPIJ001772 antibody, BDBG_08252 antibody, PAAG_02532 antibody, MCYG_05088 antibody, VDBG_06833 antibody, ACLA_015700 antibody, LOC5565620 antibody, MGYG_07634 antibody, PGTG_14279 antibody, Atm antibody
Background
ATM (ataxia telangiectasia mutated) encodes a 350-370 kDa protein. The ATM protein belongs to a family of protein kinases that appear to be involved in cell cycle control and DNA damage response. ATM kinase activity is enhanced immediately after exposure of cells to DNA double strand breaks. The C-terminal region of the protein has extensive homology to the catalytic domain of PI-3 (phosphatydilinositol-3) kinase, FAT (FRAP/ATM/TRAPP), and FAT-C (FAT-carboxy-terminal). ATM activates p53, increasing p21Cip1 levels, thus blocking activation of cdk2. That results in blockage of the G1/S transition.Synonyms: A-T mutated, ATDC, Ataxia telangiectasia mutated, Serine-protein kinase ATM, TEL1, TELO1
Gene ID
472
NCBI Accession
NP_000042
UniProt
Q13315
Pathways
p53 Signaling , Apoptosis , DNA Damage Repair , Inositol Metabolic Process , Positive Regulation of Response to DNA Damage Stimulus
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