Insulin antibody (AA 35-64)
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- Target See all Insulin (INS) Antibodies
- Insulin (INS)
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Binding Specificity
- AA 35-64
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This Insulin antibody is un-conjugated
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Application
- Western Blotting (WB)
- Purification
- Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
- Immunogen
- This INS antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 35-64 amino acids from human INS.
- Clone
- 396CT20-4-4
- Isotype
- IgM
- Top Product
- Discover our top product INS Primary Antibody
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- Application Notes
- WB: 1:1000~8000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Mouse monoclonal antibody supplied in crude ascites with 0.09 % (W/V) sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- INS Antibody (Ascites) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.
- Expiry Date
- 6 months
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- Target
- Insulin (INS)
- Alternative Name
- INS (INS Products)
- Synonyms
- IDDM2 antibody, ILPR antibody, IRDN antibody, MODY10 antibody, ins1 antibody, xins antibody, ins1-a antibody, Insulin antibody, AA986540 antibody, Ins-2 antibody, InsII antibody, Mody antibody, Mody4 antibody, proinsulin antibody, zgc:109842 antibody, igf2-A antibody, ins antibody, ins-a antibody, ins-b antibody, insulin antibody, insulin precursor antibody, insulin II antibody, preproinsulin antibody, insulin L homeolog antibody, insulin S homeolog antibody, INS antibody, INS-IGF2 antibody, ins antibody, Ins antibody, PIN antibody, Ins2 antibody, ins.L antibody, ins.S antibody
- Background
- After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq].
- Molecular Weight
- 11981
- Gene ID
- 3630
- NCBI Accession
- NP_000198, NP_001172026, NP_001172027
- UniProt
- P01308
- Pathways
- NF-kappaB Signaling, RTK Signaling, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Carbohydrate Homeostasis, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Autophagy, Negative Regulation of intrinsic apoptotic Signaling, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
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