DICER1 antibody (AA 1638-1899)

Catalog No. ABIN1721503

Product Details anti-DICER1 Antibody

Target: DICER1 (Dicer 1, Ribonuclease Type III (DICER1))

Binding Specificity: AA 1638-1899

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This DICER1 antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC)

Specificity: Reacts with human Dicer. Cross-reacts with rat protein.

Purification: Purified (protein G)

Immunogen: Fusion protein corresponding to aa 1638-1899 of mouse Endoribonuclease Dicer (accession no.Q8R418).

Clone: S167-7

Isotype: IgG1

Application Details

Application Notes: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
WB(1 μg/mL).

Positive control: Rat brain lysate.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS (1 mg/mL), pH 7.4, 50 % glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Dilute in PBS or medium which is identical to that used in the assay system.

Storage: -20 °C

Storage Comment: This antibody is stable for at least one year at -20°C. Avoid repeated freeze-thaw cycles.

Target Details for DICER1

Target: DICER1 (Dicer 1, Ribonuclease Type III (DICER1))

Alternative Name: Dicer (DICER1 Products)

Synonyms: dcr1 antibody, dicer antibody, herna antibody, DICER1 antibody, dicer1 antibody, 1110006F08Rik antibody, D12Ertd7e antibody, mKIAA0928 antibody, DCR1 antibody, Dicer antibody, HERNA antibody, MNG1 antibody, DICER antibody, fc39d11 antibody, fc74b05 antibody, wu:fc39d11 antibody, wu:fc74b05 antibody, dicer 1, ribonuclease III antibody, endoribonuclease Dicer antibody, dicer 1, ribonuclease III S homeolog antibody, dicer 1, ribonuclease type III antibody, dicer 1 ribonuclease III antibody, DICER1 antibody, CpipJ_CPIJ010534 antibody, dicer1 antibody, dicer1.S antibody, Dicer1 antibody

Background: Dicer is a member of the RNase III family that specifically cleaves double-stranded RNAs to generate microRNAs (miRNAs). After long primary transcript pri-miRNAs are processed to stem-looped premiRNAs by Drosha, pre-miRNAs are transported to the cytoplasm and further processed by Dicer to produce 22-nucleotide mature miRNAs . The mature miRNA then becomes a part of the RNA Induced Silencing Complex (RISC) and can bind to the 3' UTR of the target mRNA.

Helicase with RNase motif Helicase MOI Gene name : DICER1

Gene ID: 23405

UniProt: Q9UPY3

Pathways: Regulatory RNA Pathways, Stem Cell Maintenance, Ribonucleoprotein Complex Subunit Organization