This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells.V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation.V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain.The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits.The V1 domain contains the ATP catalytic site.The V0 domain consists of five different subunits: a, c, c', c'', and d.This gene is one of four genes in man and mouse that encode different isoforms of the a subunit.Alternatively spliced transcript variants encoding the same protein have been described.Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing.[provided by RefSeq]