SOCS3 antibody

Catalog No. ABIN207073

Product Details anti-SOCS3 Antibody

Target: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SOCS3 antibody is un-conjugated

Application: Western Blotting (WB), Blocking Antibody (Inhibition)

Specificity: The cytokine signaling is known to be regulated by a negative feedback regulator called suppressor of cytokine signaling (SOCS) inhibitors family. Members of the SOCS family have been identified due to their marked homology on the SH2 domain and a unique conserved motif referred to as the SOCS box. Expression of SOCS3 is transiently induced in a variety of immune and inflammatory situations by a wide variety of cytokines. SOCS3 is also involved in growth hormone function, leptin and insulin signaling. SOCS3 inhibits Janus kinase (JAK) tyrosine kinase activity

Purification: Protein A purified

Immunogen: Full-length SOCS3 protein.

Type of Immunogen: Recombinant protein

Clone: SO1

Isotype: IgG2b

Application Details

Application Notes: Approved: Inhb, WB

Usage: Western Blotting: Positive control - HeLa human cervix carcinoma cell line. Sample preparation: Resuspend approx. 50 mil. cells in 1 mL cold Lysis buffer (1 % laurylmaltoside in 20 mM Tris/Cl, 100 mM NaCl  pH 8.2, 50 mM NaF including Protease inhibitor Cock

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 15 mM sodium azide, approx,  pH 7.4.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: avoid freeze thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles.

Target Details for SOCS3

Target: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Alternative Name: SOCS3 (SOCS3 Products)

Synonyms: socs3 antibody, fj09e12 antibody, zgc:56537 antibody, wu:fj09e12 antibody, MGC64393 antibody, MGC75749 antibody, xsocs3 antibody, MGC81248 antibody, atod4 antibody, cis3 antibody, cish3 antibody, socs-3 antibody, ssi-3 antibody, ssi3 antibody, SOCS3 antibody, ATOD4 antibody, CIS3 antibody, Cish3 antibody, SOCS-3 antibody, SSI-3 antibody, SSI3 antibody, Cis3 antibody, EF-10 antibody, Ef10 antibody, Ssi3 antibody, Socs-3 antibody, Ssi-3 antibody, suppressor of cytokine signaling 3a antibody, suppressor of cytokine signaling 3 S homeolog antibody, suppressor of cytokine signaling 3 antibody, suppressor of cytokine signaling 3 L homeolog antibody, socs3a antibody, socs3.S antibody, socs3 antibody, socs3.L antibody, SOCS3 antibody, Socs3 antibody

Background: Name/Gene ID: SOCS3

Synonyms: SOCS3, Cish3, Cytokine-induced SH2 protein 3, CIS-3, CIS3, SSI-3, STAT-induced STAT inhibitor 3, SSI3, ATOD4, SOCS-3

Gene ID: 9021

UniProt: O14543

Pathways: JAK-STAT Signaling, Response to Growth Hormone Stimulus, Hepatitis C