beta-2 Microglobulin antibody

Catalog No. ABIN2470504

Product Details anti-beta-2 Microglobulin Antibody

Target: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This beta-2 Microglobulin antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Specificity: Specific for human beta 2 microglobulin.B2M is the beta chain of MHC class I molecules. The precursor protein has a molecular weight of approximately 14 kDa and is 119 amino acids in length.B2M is the beta chain of MHC class I molecules. The precursor protein has a molecular weight of approximately 14 kD and is 119 amino acids in length.

Purification: Protein A Column

Immunogen: B2M monoclonal antibody was raised against highly pure B2M (Human).

Clone: 2213

Isotype: IgG1

Application Details

Application Notes: B2M antibody can be used in ELISA, and immunohistochemistry starting at 5 μg/mL. Immunohistology: Pressure cooker antigen retrieval recommended

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 8.0, 0.05 % sodium azide, 10 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies avoid freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store B2M antibody at 4 °C or -20 °C.

Target Details for beta-2 Microglobulin

Target: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Alternative Name: B2M (B2M Products)

Synonyms: Ly-m11 antibody, beta2-m antibody, beta2m antibody, bwm antibody, wu:fa94c05 antibody, wu:fb10a09 antibody, b2m-W01 antibody, b2m-W03 antibody, b2m-Z01 antibody, b2m-Z02 antibody, b2m-Z03 antibody, B2M antibody, b2m antibody, B2MG antibody, wu:fb66f11 antibody, wu:fj01f08 antibody, zgc:64161 antibody, b-2-m antibody, beta-2-microglobulin antibody, beta-2 microglobulin antibody, beta-2-microglobulin S homeolog antibody, beta-2-microglobulin, like antibody, B2M antibody, B2m antibody, b2m antibody, b2m.S antibody, b2ml antibody

Background: Beta 2-microglobulin is the low molecular weight component of HLA antigens and as such is involved in the presentation of endogenous antigens, activation of T lymphocytes and functional emergence of natural killer cells. It is found in the serum of normal individuals and in the urine in elevated amounts in patients with Wilson disease, cadmium poisoning and other conditions leading renal tubular dysfunction. ESTs have been isolated from libraries generated using virtually every tissue in the body.

Gene ID: 567

UniProt: P61769

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process