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LCK antibody (N-Term)
LCK
Reactivity: Human, Mouse, Rat, Cow, Pig, Sheep, Dog, Horse, Rabbit, Guinea Pig
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-LCK Antibody
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Target
See all LCK Antibodies
LCK
(Lymphocyte-Specific Protein tyrosine Kinase (LCK))
Binding Specificity
All epitopes for LCK antibodies
N-Term
Reactivity
All reactivities for LCK antibodies
Human, Mouse, Rat, Cow, Pig, Sheep, Dog, Horse, Rabbit, Guinea Pig
Host
All hosts for LCK antibodies
Rabbit
Clonality
All clonalities for LCK antibodies
Polyclonal
Conjugate
All conjugates for LCK antibodies
This LCK antibody is un-conjugated
Application
All applications for LCK antibodies
Western Blotting (WB)
Sequence
ENCHYPIVPL DGKGTLLIRN GSEVRDPLVT YEGSNPPASP LQDNLVIALH
Predicted Reactivity
Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 93%, Sheep: 100%
Characteristics
This is a rabbit polyclonal antibody against LCK. It was validated on Western Blot.
Purification
Affinity Purified
Immunogen
The immunogen is a synthetic peptide directed towards the N-terminal region of Human LCK
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeat freeze-thaw cycles.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for LCK
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Target
LCK
(Lymphocyte-Specific Protein tyrosine Kinase (LCK))
Alternative Name
LCK (LCK Products )
Synonyms
zgc:136695 antibody, LCK antibody, Hck-3 antibody, Lsk antibody, Lskt antibody, p56 antibody, p56Lck antibody, LSK antibody, YT16 antibody, p56lck antibody, pp58lck antibody, P56LCK antibody, tkl antibody, Lck1 antibody, Lcktkr antibody, LCK proto-oncogene, Src family tyrosine kinase antibody, lymphocyte protein tyrosine kinase antibody, lck antibody, LCK antibody, Lck antibody
Background
LCK is a member of the Src family of protein tyrosine kinases (PTKs). It is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. LCK localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Protein Interaction Partner: LZTS2, CDKAL1, BAG6, UBC, WASL, WAS, env, SMAD3, SMAD2, MAPK1, HSP90AA1, Mbp, HAVCR2, PTPN22, G3BP1, nef, LAT, KHDRBS1, ADAM15, ZAP70, PAK2, LCK, CBL, SOCS3, SOCS2, SOCS1, IL2RB, CISH, YWHAQ, AJUBA, CD5, CBLB, SKAP1, SYK, SOS1, CD38, CD247, CD3E, FAM174A, Protein Size: 363
Molecular Weight
39 kDa
Gene ID
3932
Pathways
TCR Signaling , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Transition Metal Ion Homeostasis , Positive Regulation of Endopeptidase Activity , CXCR4-mediated Signaling Events , Thromboxane A2 Receptor Signaling
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