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Caspase 9 antibody (pThr125)
CASP9
Reactivity: Human, Mouse, Rat
WB, IHC
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-Caspase 9 Antibody
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Target
See all Caspase 9 (CASP9) Antibodies
Caspase 9 (CASP9)
(Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9))
Binding Specificity
All epitopes for Caspase 9 antibodies
pThr125
Reactivity
All reactivities for Caspase 9 antibodies
Human, Mouse, Rat
Host
All hosts for Caspase 9 antibodies
Rabbit
Clonality
All clonalities for Caspase 9 antibodies
Polyclonal
Conjugate
All conjugates for Caspase 9 antibodies
This Caspase 9 antibody is un-conjugated
Application
All applications for Caspase 9 antibodies
Western Blotting (WB), Immunohistochemistry (IHC)
Specificity
The antiserum was produced against synthesized phosphopeptide derived from human Caspase 9 around the phosphorylation site of threonine 125 (P-E-TP-P-R).
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogen
Caspase 9 (phospho Thr125) antibody was raised against a peptide sequence around phosphorylation site of threonine 125 (P-E-T (p)-P-R) derived from Human Caspase 9.
Isotype
IgG
Top Product
Discover our top product CASP9 Primary Antibody
Alternatives
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anti-Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) (AA 11-120) antibody
CASP9
Reactivity: Human, Mouse, Rat, Chicken, Dog, Rabbit
WB, ELISA, IHC (p), FACS, IF (p), IF (cc), IHC (fro)
Host: Rabbit
Polyclonal
unconjugated
Application Details
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Application Notes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store antibody at -20°C for up to one year.
Target Details for Caspase 9
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Target
Caspase 9 (CASP9)
(Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9))
Alternative Name
Caspase 9 (CASP9 Products )
Synonyms
CASP9 antibody, AI115399 antibody, APAF-3 antibody, AW493809 antibody, CASP-9 antibody, Caspase-9 antibody, ICE-LAP6 antibody, Mch6 antibody, Apaf3 antibody, Casp-9-CTD antibody, Casp9_v1 antibody, Ice-Lap6 antibody, APAF3 antibody, MCH6 antibody, PPP1R56 antibody, caspase 9 antibody, CASP9 antibody, Casp9 antibody
Background
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
Molecular Weight
47 kDa
Gene ID
842
NCBI Accession
NP_001220
UniProt
P55211
Pathways
MAPK Signaling , RTK Signaling , Apoptosis , Caspase Cascade in Apoptosis , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Positive Regulation of Endopeptidase Activity
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