IRAK1 antibody (pSer376)

Catalog No. ABIN2568272

Product Details anti-IRAK1 Antibody

Target: IRAK1 (Interleukin-1 Receptor-Associated Kinase 1 (IRAK1))

Binding Specificity: pSer376

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRAK1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Specificity: The antibody detects endogenous levels of IRAK1 only when phosphorylated at serine 376.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: IRAK1 (phospho Ser376) antibody was raised against a peptide sequence around phosphorylation site of Serine 376 (Q-S-S (p)-M-V) derived from Human IRAK1.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store antibody at -20°C for up to one year.

Target Details for IRAK1

Target: IRAK1 (Interleukin-1 Receptor-Associated Kinase 1 (IRAK1))

Alternative Name: IRAK1 (IRAK1 Products)

Synonyms: IRAK1 antibody, IRAK antibody, pelle antibody, AA408924 antibody, IRAK-1 antibody, IRAK1-S antibody, Il1rak antibody, Plpk antibody, mPLK antibody, RGD1563841 antibody, interleukin 1 receptor associated kinase 1 antibody, interleukin-1 receptor-associated kinase 1 antibody, IRAK1 antibody, irak1 antibody, Irak1 antibody

Background: IRAK1 encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK1 is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B.

Molecular Weight: 76 kDa

Gene ID: 3654

NCBI Accession: NP_001560

UniProt: P51617

Pathways: NF-kappaB Signaling, TLR Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades