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PERK antibody (pThr981)
EIF2AK3
Reactivity: Human, Mouse
IHC
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-PERK Antibody
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Target
See all PERK (EIF2AK3) Antibodies
PERK (EIF2AK3)
(Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3))
Binding Specificity
All epitopes for PERK antibodies
pThr981
Reactivity
All reactivities for PERK antibodies
Human, Mouse
Host
All hosts for PERK antibodies
Rabbit
Clonality
All clonalities for PERK antibodies
Polyclonal
Conjugate
All conjugates for PERK antibodies
This PERK antibody is un-conjugated
Application
All applications for PERK antibodies
Immunohistochemistry (IHC)
Specificity
The antibody detects endogenous levels of PEK/PERK only when phosphorylated at threonine 981.
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogen
PEK/PERK (phospho Thr981) antibody was raised against a peptide sequence around phosphorylation site of threonine 981 (A-R-H (p)-T-G) derived from Human PEK/PERK.
Isotype
IgG
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Alternatives
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anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3) (pThr980) antibody
EIF2AK3
Reactivity: Human, Mouse, Rat, Dog, Pig
WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro)
Host: Rabbit
Polyclonal
unconjugated
Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store antibody at -20°C for up to one year.
Target Details for PERK
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Target
PERK (EIF2AK3)
(Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3))
Alternative Name
PEK/PERK (EIF2AK3 Products )
Synonyms
EIF2AK3 antibody, AI427929 antibody, Pek antibody, Perk antibody, PEK antibody, PERK antibody, WRS antibody, eukaryotic translation initiation factor 2 alpha kinase 3 antibody, EIF2AK3 antibody, Eif2ak3 antibody
Background
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1)
Molecular Weight
125 kDa
Gene ID
9451
NCBI Accession
NP_004827
UniProt
Q9NZJ5
Pathways
Hormone Transport , ER-Nucleus Signaling , Positive Regulation of Endopeptidase Activity , Hepatitis C , Unfolded Protein Response
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