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TRKA antibody (pTyr791)
NTRK1
Reactivity: Human
IHC
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-TRKA Antibody
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Target
See all TRKA (NTRK1) Antibodies
TRKA (NTRK1)
(Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
Binding Specificity
All epitopes for TRKA antibodies
pTyr791
Reactivity
All reactivities for TRKA antibodies
Human
Host
All hosts for TRKA antibodies
Rabbit
Clonality
All clonalities for TRKA antibodies
Polyclonal
Conjugate
All conjugates for TRKA antibodies
This TRKA antibody is un-conjugated
Application
All applications for TRKA antibodies
Immunohistochemistry (IHC)
Specificity
The antibody detects endogenous levels of Trk A only when phosphorylated at tyrosine 791.
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogen
Trk A (phospho Tyr791) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 791 (P-V-Y (p)-L-D) derived from Human Trk A.
Isotype
IgG
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Discover our top product NTRK1 Primary Antibody
Alternatives
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anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 725-821) antibody
NTRK1
Reactivity: Human, Mouse, Rat
WB, ELISA, IF (cc), IF (p), FACS, IHC (p), IHC (fro)
Host: Rabbit
Polyclonal
unconjugated
anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (2nd Extracellular Domain), (AA 342-356) antibody
NTRK1
Reactivity: Human, Mouse, Rat
WB, IHC, IF, FACS, ICC, LCI
Host: Rabbit
Polyclonal
unconjugated
Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store antibody at -20°C for up to one year.
Target Details for TRKA
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Target
TRKA (NTRK1)
(Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
Alternative Name
Trk A (NTRK1 Products )
Synonyms
MTC antibody, TRK antibody, TRK1 antibody, TRKA antibody, Trk-A antibody, p140-TrkA antibody, CDHF12 antibody, CDHR16 antibody, HSCR1 antibody, MEN2A antibody, MEN2B antibody, MTC1 antibody, PTC antibody, RET-ELE1 antibody, RET51 antibody, Trk antibody, C80751 antibody, Tkr antibody, TrkA antibody, trk antibody, trka antibody, CTRKA antibody, trkA antibody, neurotrophic receptor tyrosine kinase 1 antibody, ret proto-oncogene antibody, neurotrophic tyrosine kinase, receptor, type 1 antibody, NTRK1 antibody, RET antibody, Ntrk1 antibody, ntrk1 antibody
Background
Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.
Molecular Weight
140 kDa
Gene ID
4914
NCBI Accession
NP_002520
UniProt
P04629
Pathways
RTK Signaling , Neurotrophin Signaling Pathway , cAMP Metabolic Process
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