CDKN2B antibody (Middle Region)
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- Target See all CDKN2B Antibodies
- CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))
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Binding Specificity
- Middle Region
- Reactivity
- Human, Mouse, Rat, Pig, Dog, Rabbit, Guinea Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CDKN2B antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- REGFLDTLVV LHRAGARLDV RDAWGRLPVD LAEERGHRDV AGYLRTATGD
- Predicted Reactivity
- Dog: 91%, Guinea Pig: 83%, Mouse: 83%, Pig: 100%, Rabbit: 91%, Rat: 83%
- Characteristics
- This is a rabbit polyclonal antibody against CDKN2B. It was validated on Western Blot using a cell lysate as a positive control.
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human CDKN2B
- Top Product
- Discover our top product CDKN2B Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 138 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))
- Alternative Name
- CDKN2B (CDKN2B Products)
- Synonyms
- p14-INK4b antibody, cdk4l antibody, ink4b antibody, mts2 antibody, p15 antibody, p15ink4b antibody, tp15 antibody, CDK4I antibody, INK4B antibody, MTS2 antibody, P15 antibody, TP15 antibody, p15INK4b antibody, AV083695 antibody, INK4b antibody, p15(INK4b) antibody, CDKN2A antibody, cyclin dependent kinase inhibitor 2B antibody, Cyclin-dependent kinase 4 inhibitor B antibody, cyclin-dependent kinase inhibitor 2B antibody, cyclin-dependent kinase inhibitor 2B L homeolog antibody, cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) antibody, CDKN2B antibody, cdn2b antibody, cdkn2b antibody, cdkn2b.L antibody, Cdkn2b antibody
- Background
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CDKN2B's gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. CDKN2B is a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition.
Alias Symbols: P15, MTS2, TP15, CDK4I, INK4B, p15INK4b
Protein Interaction Partner: UBC, TRAF1, CDK6, CCDC33, NIF3L1, CDK4, PYCRL, RNF20, TGFB1I1, ISL1, APP, KIAA1377, CCDC90B, ARPC3, ZBTB17, IKBKAP, CDK8, MAGEA11, PIAS2,
Protein Size: 138 - Molecular Weight
- 15 kDa
- Gene ID
- 1030
- NCBI Accession
- NM_004936, NP_004927
- UniProt
- P42772
- Pathways
- Cell Division Cycle, Mitotic G1-G1/S Phases
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