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PLOD2 antibody (Middle Region)

PLOD2 Reactivity: Human, Rat, Mouse, Cow, Dog, Horse, Pig, Rabbit WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2775556
  • Target See all PLOD2 Antibodies
    PLOD2 (Procollagen-Lysine 2-Oxoglutarate 5-Dioxygenase 2 (PLOD2))
    Binding Specificity
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 22
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Rat, Mouse, Cow, Dog, Horse, Pig, Rabbit
    Host
    • 17
    • 6
    Rabbit
    Clonality
    • 19
    • 4
    Polyclonal
    Conjugate
    • 19
    • 2
    • 1
    • 1
    This PLOD2 antibody is un-conjugated
    Application
    • 18
    • 6
    • 6
    • 5
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    IKGKTLRSEM NERNYFVRDK LDPDMALCRN AREMTLQREK DSPTPETFQM
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
    Characteristics
    This is a rabbit polyclonal antibody against PLOD2. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human PLOD2
    Top Product
    Discover our top product PLOD2 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 758 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).

  • Target
    PLOD2 (Procollagen-Lysine 2-Oxoglutarate 5-Dioxygenase 2 (PLOD2))
    Alternative Name
    PLOD2 (PLOD2 Products)
    Synonyms
    D530025C14Rik antibody, LH2 antibody, Plod-2 antibody, TLH antibody, procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 antibody, procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 antibody, Plod2 antibody, PLOD2 antibody
    Background
    PLOD2 forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
    Alias Symbols: LH2, TLH
    Protein Interaction Partner: ITGB1BP2, SUPT5H, CSDE1, SF1, UGP2, TPP2, VASN, RNF123, NUSAP1, SAMHD1, DNPEP, GANAB, SWAP70, XPO7, PACSIN2, FAF1, HSPH1, SEC23A, PRMT3, FARSB, USP15, RANBP3, SET, RPL24, PTPN12, NCL, NARS, JUP, GART, XRCC6, AP2B1, gag-pol, UBL4A, OS9, FBXO6, UBC, VHL, Fa
    Protein Size: 758
    Molecular Weight
    84 kDa
    Gene ID
    5352
    NCBI Accession
    NM_182943, NP_891988
    Pathways
    SARS-CoV-2 Protein Interactome
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