GRIN2B antibody (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B) (Middle Region) Primary Antibody
GRIN2B Reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat IHC, WB Host: Rabbit Polyclonal
Catalog No. ABIN2776121
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- Binding Specificity
- Middle Region
- Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
- This GRIN2B antibody is un-conjugated
- Immunohistochemistry (IHC), Western Blotting (WB)
- Blocking Peptide
- Blocking peptide for this product available: ABIN977684
- RSPDHKRYFR DKEGLRDFYL DQFRTKENSP HWEHVDLTDI YKERSDDFKR
- Predicted Reactivity
- Cow: 79%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
- This is a rabbit polyclonal antibody against GRIN2B. It was validated on Western Blot using a cell lysate as a positive control.
- Affinity Purified
- The immunogen is a synthetic peptide directed towards the middle region of human GRIN2B
- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
Antigen size: 1484 AA
- For Research Use only
- Lot specific
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
- Alternative Name
- GRIN2B (GRIN2B Antibody Abstract)
- GRIN2B is the NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium.N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. Sequence Note: This RefSeq was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-544 U90278.1 31-574 545-545 U88963.1 545-545 546-3677 U90278.1 576-3707 3678-5941 AC007535.3 145452-147715
Alias Symbols: MGC142178, MGC142180, NMDAR2B, NR2B, hNR3, MRD6, GluN2B
Protein Interaction Partner: SPTAN1, PRKCA, FYN, CAMK2G, DLG4, DLG1, KDM5B, TANC1, SYNGAP1, GRIN1, CAMK2N1, ARHGAP32, EXOC4, CAMK2B, MAGI3, LIN7B, CAMK2D, GRIN3A, CAMK2A, DLG2, AP1M1, LIN7A, INADL, IL16, PARK2, AP4M1, AP2M1, EPHB2, DLG3, SRC, GNB2L1, PRKCG, PRKCB, PTPN11, PLCG1, PIK3
Protein Size: 1484
- Molecular Weight
- 163 kDa
- Gene ID
- NCBI Accession
- NM_000834, NP_000825
- Response to Growth Hormone Stimulus, Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity
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