XRCC6 antibody (N-Term)
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- Target See all XRCC6 Antibodies
- XRCC6 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6))
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Binding Specificity
- N-Term
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Reactivity
- Human, Mouse, Rat, Rabbit, Dog, Guinea Pig, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This XRCC6 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- NFKNIYVLQE LDNPGAKRIL ELDQFKGQQG QKRFQDMMGH GSDYSLSEVL
- Predicted Reactivity
- Dog: 93%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 86%, Rat: 93%
- Characteristics
- This is a rabbit polyclonal antibody against G22P1. It was validated on Western Blot and immunohistochemistry.
- Purification
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human G22P1
- Top Product
- Discover our top product XRCC6 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 609 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- XRCC6 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6))
- Alternative Name
- G22P1 (XRCC6 Products)
- Synonyms
- CTC75 antibody, CTCBF antibody, G22P1 antibody, KU70 antibody, ML8 antibody, TLAA antibody, 70kDa antibody, G22p1 antibody, Ku70 antibody, Kup70 antibody, X-ray repair cross complementing 6 antibody, ATP-dependent DNA helicase II, 70 kDa subunit antibody, X-ray repair complementing defective repair in Chinese hamster cells 6 L homeolog antibody, X-ray repair complementing defective repair in Chinese hamster cells 6 antibody, XRCC6 antibody, Bm1_41430 antibody, xrcc6.L antibody, Xrcc6 antibody
- Background
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The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.
Alias Symbols: ML8, KU70, TLAA, CTC75, CTCBF, G22P1
Protein Interaction Partner: UBC, ELF3, EHF, CHD1L, SUMO2, SUMO3, MDM2, EMD, ATRX, RPA3, RPA2, RPA1, PCNA, EED, PRPF40A, SUPT5H, ST13, SET, PLOD2, PIN1, NARS, MSH2, RPSA, JUP, IMPDH1, MSH6, GART, DPYSL3, CTNNA1, SAMHD1, ATP6V1B2, GANAB, SWAP70, WBP4, HYOU1, FARSB, RANBP3, CUL2, CSDE1
Protein Size: 609 - Molecular Weight
- 70 kDa
- Gene ID
- 2547
- NCBI Accession
- NM_001469, NP_001460
- UniProt
- Q6FG89
- Pathways
- DNA Damage Repair
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