VHL antibody (N-Term)
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- Target See all VHL Antibodies
- VHL (Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL))
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Binding Specificity
- N-Term
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Reactivity
- Human, Mouse, Rat, Dog, Guinea Pig, Cow
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This VHL antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- EDGGEESGAE ESGPEESGPE ELGAEEEMEA GRPRPVLRSV NSREPSQVIF
- Predicted Reactivity
- Cow: 93%, Dog: 93%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against VHL. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product VHL Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 172 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- VHL (Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL))
- Alternative Name
- VHL (VHL Products)
- Synonyms
- HRCA1 antibody, RCA1 antibody, VHL1 antibody, pVHL antibody, BcDNA:RH61560 antibody, CG13221 antibody, DVhl antibody, Dmel\\CG13221 antibody, Dvhl antibody, VHL antibody, d-VHL antibody, d-vhl antibody, dVHL antibody, dmVHL antibody, vhl antibody, rca1 antibody, vhl1 antibody, hrca1 antibody, zgc:158722 antibody, Vhlh antibody, von Hippel-Lindau tumor suppressor antibody, von Hippel-Lindau antibody, von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase antibody, von Hippel-Lindau disease tumor suppressor antibody, VHL antibody, Vhl antibody, vhl antibody, CpipJ_CPIJ009992 antibody
- Background
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Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Alias Symbols: HRCA1, RCA1, VHL1, pVHL
Protein Interaction Partner: ELC1, HIF1A, UBC, TPT1, MDFI, USP33, KAT2B, E2F1, TCP1, HSP90AA1, HSPA4, GLI1, EP300, SIRT1, AURKA, PARK7, RBX1, PDCD5, CUL2, TCEB2, TCEB1, AR, PIAS4, ILF3, HNRNPL, HNRNPA2B1, PRMT1, PRMT8, SON, SLC3A2, SLC2A1, RPS15A, RPL21, RPL5, HIST4H4, ACTB, VAPB, HI
Protein Size: 172 - Molecular Weight
- 19 kDa
- Gene ID
- 7428
- NCBI Accession
- NM_198156, NP_937799
- Pathways
- Tube Formation, Signaling Events mediated by VEGFR1 and VEGFR2, Ubiquitin Proteasome Pathway
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