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Estrogen Receptor alpha antibody (AA 410-592)
ESR1
Reactivity: Human
WB, IHC, ELISA
Host: Mouse
Monoclonal
unconjugated
Product Details anti-Estrogen Receptor alpha Antibody
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Target
See all Estrogen Receptor alpha (ESR1) Antibodies
Estrogen Receptor alpha (ESR1)
(Estrogen Receptor 1 (ESR1))
Binding Specificity
All epitopes for Estrogen Receptor alpha antibodies
AA 410-592
Reactivity
All reactivities for Estrogen Receptor alpha antibodies
Human
Host
All hosts for Estrogen Receptor alpha antibodies
Mouse
Clonality
All clonalities for Estrogen Receptor alpha antibodies
Monoclonal
Conjugate
All conjugates for Estrogen Receptor alpha antibodies
This Estrogen Receptor alpha antibody is un-conjugated
Application
All applications for Estrogen Receptor alpha antibodies
Western Blotting (WB), Immunohistochemistry (IHC), ELISA
Purification
Purified antibody
Immunogen
Purified recombinant fragment of human ER-alpha (410-592aa) expressed in E. Coli.
Isotype
IgG1
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1.0 mg/mL
Buffer
PBS containing 0.03 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Target Details for Estrogen Receptor alpha
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Target
Estrogen Receptor alpha (ESR1)
(Estrogen Receptor 1 (ESR1))
Alternative Name
ER alpha (ESR1 Products )
Synonyms
LOC398734 antibody, AA420328 antibody, AU041214 antibody, ER-alpha antibody, ER[a] antibody, ERa antibody, ERalpha antibody, ESR antibody, Estr antibody, Estra antibody, Nr3a1 antibody, NR3A1 antibody, eralpha antibody, zfER[a] antibody, ER antibody, ESRA antibody, ESTRR antibody, Era antibody, akap12 antibody, cb27 antibody, esr1 antibody, fb72g12 antibody, id:ibd1202 antibody, sb:cb27 antibody, si:ch73-192g21.1 antibody, wu:fb72g12 antibody, wu:fc21c03 antibody, Esr antibody, RNESTROR antibody, ERALPHA antibody, er antibody, esr antibody, nr3a1 antibody, XER antibody, era antibody, esra antibody, ERbeta antibody, xesr-1 antibody, xlERalpha1 antibody, xlERalpha2 antibody, ESR1 antibody, estrogen receptor 1 L homeolog antibody, estrogen receptor 1 (alpha) antibody, estrogen receptor 1 antibody, A kinase (PRKA) anchor protein 12b antibody, esr1.L antibody, Esr1 antibody, ESR1 antibody, esr1 antibody, akap12b antibody
Background
The estrogen receptor (ER) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Alternative splicing results in several ER mRNA transcripts, which differ primarily in their 5-prime untranslated regions. Two isoforms of the human ER, ERA and ER beta , occur, each with distinct tissue and cell patterns of expression. Pelletier and El-Alfy (2000) studied the immunocytochemical localization of ESRA and ESRB in human reproductive tissues. In the ovary, ERB immunoreactivity was found in nuclei of granulosa cells of growing follicles at all stages from primary to mature follicles, interstitial gland, and germinal epithelium cells. Nuclear staining for ERA occurred in thecal, interstitial gland, and germinal epithelium cells. In the uterus, strong ERA immunoreactivity was detected in nuclei of epithelial, stromal, and muscle cells.
Molecular Weight
68 kDa
Gene ID
2099
UniProt
P03372
Pathways
Nuclear Receptor Transcription Pathway , EGFR Signaling Pathway , Retinoic Acid Receptor Signaling Pathway , Intracellular Steroid Hormone Receptor Signaling Pathway , Steroid Hormone Mediated Signaling Pathway , Ribonucleoprotein Complex Subunit Organization , Ribosome Assembly
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