JAK2 antibody (pTyr1007)

Catalog No. ABIN3020271

Product Details anti-JAK2 Antibody

Target: JAK2 (Janus Kinase 2 (JAK2))

Binding Specificity: pTyr1007

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This JAK2 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Human, Mouse

Characteristics: Phosphorylated Antibodies

Immunogen: A phospho specific peptide corresponding to residues surrounding Y1007 of human Phospho-JAK2-Y1007

Isotype: IgG

Application Details

Application Notes: WB,1:200 - 1:2000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-JAK2 antibody (ABIN3020271)

He, Yang, Li, Shao, Wei, Wang, Li, Xu: "Exogenous spermine ameliorates high glucose-induced cardiomyocytic apoptosis via decreasing reactive oxygen species accumulation through inhibiting p38/JNK and JAK2 pathways." in: International journal of clinical and experimental pathology, Vol. 8, Issue 12, pp. 15537-49, (2016) (PubMed).

Target Details for JAK2

Target: JAK2 (Janus Kinase 2 (JAK2))

Alternative Name: JAK2 (JAK2 Products)

Synonyms: JAK2bCA antibody, jak2 antibody, JTK10 antibody, THCYT3 antibody, AI504024 antibody, C81284 antibody, Fd17 antibody, JAK-2 antibody, Janus kinase 2b antibody, Janus kinase 2 antibody, jak2b antibody, JAK2 antibody, Jak2 antibody

Background: This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.,JAK2,JTK10,THCYT3,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,Phosphorylation,Cancer,Signal Transduction,Kinase,Tyrosine kinases,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Inhibition of Apoptosis,Cell Cycle,Cell cycle inhibitors,Immunology & Inflammation,IL-6 Receptor Signaling Pathway,Protein phosphorylation,JAK2

Molecular Weight: 130 kDa

Gene ID: 3717

UniProt: O60674

Pathways: JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling, Unfolded Protein Response