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Retinoblastoma 1 antibody (pSer795)
RB1
Reactivity: Human
WB, IHC
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-Retinoblastoma 1 Antibody
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Target
See all Retinoblastoma 1 (RB1) Antibodies
Retinoblastoma 1 (RB1)
Binding Specificity
All epitopes for Retinoblastoma 1 antibodies
pSer795
Reactivity
All reactivities for Retinoblastoma 1 antibodies
Human
Host
All hosts for Retinoblastoma 1 antibodies
Rabbit
Clonality
All clonalities for Retinoblastoma 1 antibodies
Polyclonal
Conjugate
All conjugates for Retinoblastoma 1 antibodies
This Retinoblastoma 1 antibody is un-conjugated
Application
All applications for Retinoblastoma 1 antibodies
Western Blotting (WB), Immunohistochemistry (IHC)
Sequence
PSSPL
Cross-Reactivity
Human, Mouse, Rat
Characteristics
Phosphorylated Antibodies
Purification
Affinity purification
Immunogen
A synthetic phosphorylated peptide around S795 of human RB (NP_000312.2).
Isotype
IgG
Top Product
Discover our top product RB1 Primary Antibody
Alternatives
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Application Details
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Application Notes
WB,1:500 - 1:1000,IHC,1:50 - 1:200
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid freeze / thaw cycles
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
Target Details for Retinoblastoma 1
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Target
Retinoblastoma 1 (RB1)
Alternative Name
RB1 (RB1 Products )
Synonyms
OSRC antibody, RB antibody, p105-Rb antibody, pRb antibody, pp110 antibody, Rb antibody, Rb-1 antibody, P105-RB antibody, PP110 antibody, RB11 antibody, zgc:154147 antibody, RB transcriptional corepressor 1 antibody, RB transcriptional corepressor like 1 antibody, retinoblastoma 1 antibody, RB1 antibody, RBL1 antibody, Rb1 antibody, rb1 antibody
Background
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.,OSRC,PPP1R130,RB,p105-Rb,pRb,pp110,RB1,Rb,Epigenetics & Nuclear Signaling,Transcription Factors,DNA Damage & Repair,Cancer,Tumor suppressors,Cell Biology & Developmental Biology,Cell Cycle,Cell cycle inhibitors,G1/S Checkpoint,Protein phosphorylation,RB1
Molecular Weight
106 kDa
Gene ID
5925
UniProt
P06400
Pathways
Cell Division Cycle , Intracellular Steroid Hormone Receptor Signaling Pathway , Mitotic G1-G1/S Phases , DNA Replication , Maintenance of Protein Location , Synthesis of DNA , Autophagy
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