CD46 antibody
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- Target See all CD46 Antibodies
- CD46
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This CD46 antibody is un-conjugated
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Application
- Flow Cytometry (FACS), Immunofluorescence (IF)
- Purification
- Protein G affinity chromatography
- Immunogen
- Recombinant human protein was used as the immunogen for this CD46 antibody.
- Clone
- 122-2
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product CD46 Primary Antibody
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- Application Notes
- The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the CD46 antibody to be titered up or down for optimal performance.\. FACS: 0.5-1 μg/million cells,IF: 0.5-1 μg/mL
- Restrictions
- For Research Use only
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- Concentration
- 0.2 mg/mL
- Buffer
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store the CD46 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
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- Target
- CD46
- Alternative Name
- CD46 (CD46 Products)
- Synonyms
- AHUS2 antibody, MCP antibody, MIC10 antibody, TLX antibody, TRA2.10 antibody, Mcp antibody, CD46 antibody, CD46 molecule antibody, CD46 antigen, complement regulatory protein antibody, CD46 molecule, complement regulatory protein antibody, membrane cofactor protein-like antibody, CD46 antibody, Cd46 antibody, LOC100341359 antibody, LOC103789310 antibody
- Background
- CD46 acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
- Gene ID
- 4179
- Pathways
- Regulation of Actin Filament Polymerization
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