c-MYC antibody (AA 408-439)

Catalog No. ABIN3026176

The Mouse Monoclonal anti-c-MYC antibody (Clone MYC699) (ABIN3026176) specifically detects c-MYC in IF, ELISA and FACS. The antibody is reactive with Human samples.

Quick Overview for c-MYC antibody (AA 408-439) (ABIN3026176)

Target: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This c-MYC antibody is un-conjugated

Application: Immunofluorescence (IF), ELISA, Flow Cytometry (FACS)

Grade: Carrier-free

Clone: MYC699

Product Details anti-c-MYC Antibody

Binding Specificity: AA 408-439

Purpose: c-Myc Antibody (azide and preservative free)

Sequence: AEEQKLISEE DLLRKRREQL KHKLEQLRNS CA

No Cross-Reactivity: Mouse (Murine)

Purification: Protein G affinity chromatography

Immunogen: Amino acids 408-439 (AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA) from the human protein were used as the immunogen for this c-Myc antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: The optimal dilution of the c-Myc antibody for each application should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the c-Myc antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for c-MYC

Target: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Alternative Name: c-Myc

Background: The c-Myc protein is a transcription factor, which is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies also have shown that c-Myc is essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells, and which brought extensive attention in the development of new therapeutic approach for cancer treatment.

UniProt: P01106

Pathways: p53 Signaling, Cell Division Cycle, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Warburg Effect